DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pcl and ints12

DIOPT Version :9

Sequence 1:	NP_001261067.1	Gene:	Pcl / 37069	FlyBaseID:	FBgn0003044	Length:	1043	Species:	Drosophila melanogaster
Sequence 2:	NP_001002161.2	Gene:	ints12 / 415251	ZFINID:	ZDB-GENE-040625-178	Length:	479	Species:	Danio rerio

Alignment Length:	284	Identity:	66/284 - (23%)
Similarity:	84/284 - (29%)	Gaps:	106/284 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 KAILPLIDSSTADSSSCSSSSVSSSSYSGTATTSAAVVIVDEPDSTTTTPQTPPTTPEAMSSPGK 293
            |..||.:  :..||.|.||||||||                     .||           |:..|
Zfish    58 KVSLPKM--TKQDSKSSSSSSVSSS---------------------ITT-----------SNSSK 88

  Fly   294 SSPSPPLLATQSLLKGVNSMKPSFK-TVEAAPPTPPTPPSPPPPPPAPPVAAPSPAVTYALQEDV 357
            ||.|.            .|.|.|.| |:|.....|.....||..|......:.|..:.:
Zfish    89 SSISE------------KSKKESEKRTLEKIRVDPGEGVEPPKKPRLEKQDSHSSPIAF------ 135

  Fly   358 FIKCNDGRFYLGTIIDQTSDQYLIRFDDQSEQWCEPDKLRKLGGGSSITAGGGGASTTESTNTSP 422
                            ||.|..:..|.|..|                         |........
Zfish   136 ----------------QTKDIPIPDFTDIDE-------------------------TNADDFAME 159

  Fly   423 SGPMCVACKRSDI---EDVVEICERCGRGYHRGCTVEIVTGSG------IWSCKRCAKPMK-MQQ 477
            .|..||.|::..:   ..:|| |:.|...||:.|....||...      :|.|.||.:.|| |.|
Zfish   160 MGLACVVCRQMTVTSGNQLVE-CQECHNLYHQECHKPQVTDKDVNDPRLVWYCARCTRQMKRMAQ 223

  Fly   478 PVSHKITKPA-GICRQLPYHADKL 500
            .......||| .:...:|...|.|
Zfish   224 KTQKPPQKPAPALATTVPLLKDPL 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pcl	NP_001261067.1	TUDOR	350..399	CDD:197660	6/48 (13%)
		PHD_SF	426..469	CDD:304600	14/51 (27%)
		PHD2_MTF2_PHF19_like	514..565	CDD:276978
		Mtf2_C	985..1032	CDD:290768
ints12	NP_001002161.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	57..140		34/149 (23%)
		PHD_Int12	163..214	CDD:276976	14/51 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..241		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	274..293
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..479
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4323
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900