DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pcl and Mtf2

DIOPT Version :9

Sequence 1:	NP_001261067.1	Gene:	Pcl / 37069	FlyBaseID:	FBgn0003044	Length:	1043	Species:	Drosophila melanogaster
Sequence 2:	XP_038948078.1	Gene:	Mtf2 / 360905	RGDID:	1304727	Length:	604	Species:	Rattus norvegicus

Alignment Length:	743	Identity:	188/743 - (25%)
Similarity:	274/743 - (36%)	Gaps:	239/743 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   344 APSPAVTYALQEDVFIKCNDGRFYLGTI--IDQTSDQYLIRFDDQSEQWCEPDKLRKLGGGSSIT 406
            |..||..:...:||..:.:||.||||||  |:.......|.|:|.|:.|.    |.|     .|.
  Rat    50 AKKPACKFEEGQDVLARWSDGLFYLGTIKKINILKQSCFITFEDSSKSWV----LWK-----DIQ 105

  Fly   407 AGGGGASTTESTNTSPSGPM-CVACKR--SDIEDVVEICERCGRGYHRGCTVEIVTGSGI----- 463
            .|..|           ||.| |..|:.  |:..:.:.||::||:|||:.|....:..|.|
  Rat   106 TGATG-----------SGEMVCTICQEEYSEAPNEMVICDKCGQGYHQLCHTPHIDSSVIDSDEK 159

  Fly   464 WSCKRCAKPMKMQQPVSHKITKPAGICRQ-------------LPYHADKLSWDEKHRVNEEQIYC 515
            |.|::|         |....||..|..::             |||....|.||..|:.|.:|.||
  Rat   160 WLCRQC---------VFATTTKRGGALKKGPNAKALQVMKQTLPYSVADLEWDAGHKTNVQQCYC 215

  Fly   516 YCGKPGKFDHNMLQCCKCRNWFHTQCMQNFKKKLLRGDMFFVFCCTVCNNGIEFVRRMQIEWVDV 580
            |||.||.:...|||||||:.|||..|:|..:|.:|.||.|:.|.|:||::|.|:::|:.::|||:
  Rat   216 YCGGPGDWYLKMLQCCKCKQWFHEACVQCLQKPMLFGDRFYTFICSVCSSGPEYLKRLPLQWVDI 280

  Fly   581 LHIALYNLRKHQHQKYHH-------LLNDIWPFILEQRHQLPICEKWRTLPETALMERLKQTLKD 638
            .|:.||||.....:||..       .:||.|    ::.|...:.:    .|::...|.:.:.|.|
  Rat   281 AHLCLYNLSVIHKKKYFDSELELMTYINDNW----DRLHPGELAD----TPKSERYEHVLEALND 337

  Fly   639 YSDRFVCGREFKRAPAFYALRHSGPPHIPKVFLEPHEELSDELLEKRFKLMLMPEEPDEGANELP 703
            |...|:.|:|.|:....:.||...||..|.|               .||    .|:..||.:
  Rat   338 YKTMFMSGKEIKKKKHLFGLRIRVPPVPPNV---------------AFK----AEKEPEGTS--- 380

  Fly   704 KRVPKDVYEFNTDEDDPVETSEDEIPIKQIIEKAKKQAA----------QKADKHDELPLKPDLA 758
                   :||........:.:.|...:...|||..|:.:          :...|..|.||..:..
  Rat   381 -------HEFKIKGRKASKPTSDSREVSNGIEKKGKKKSVGRPPGPYTRKMIQKTAEPPLGKESV 438

  Fly   759 DDNANDGDPGKLPAPIPPLLDANSSRKRKAFRLSKRYDNSRNHCDLSSDENSSSSRGTSSLDLII 823
            .:|              |.||.                    .|.:...|..:.|..||.:||
  Rat   439 SEN--------------PALDL--------------------PCSIGRTEGVAHSSNTSDVDL-- 467

  Fly   824 PPPVNFLGRNNPFLMATPKKASQGRSISVGTGVGVNGIINSIFKLKGTSKEQPRMVRTIKRRLSA 888
                                          ||..                             ||
  Rat   468 ------------------------------TGAS-----------------------------SA 473

  Fly   889 KDITIGPNQEVRRRRTRRLTTAIEVISTTTINPIPSHY-LPIYAKDLQ-----PPAPPMGKPTHG 947
            |:                          ||.:.||.|| |....|..:     |.:.|..:...|
  Rat   474 KE--------------------------TTSSSIPRHYGLSDSRKRTRTGRSWPASIPHLRRRRG 512

  Fly   948 RLLR-----QRPQKQSPSQSRRNSTSSTATSSSSNGIGAPGHSMLDLKQSVNKYFGGAMNRIDAG 1007
            ||.|     |..:.....:.:.:.......:...|.:......:..||.|:..|||.| .||..|
  Rat   513 RLPRRALHTQNSEVVKDDEGKEDYQFEELNTEILNNLADQELQLNHLKNSITSYFGAA-GRIACG 576

  Fly  1008 EPFAIRAKRRMGNGQVQYLVEWGGDTAT 1035
            |.:.:.|:|...:|:|||||||.|.||:
  Rat   577 EKYRVLARRVTLDGKVQYLVEWEGATAS 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pcl	NP_001261067.1	TUDOR	350..399	CDD:197660	17/50 (34%)
		PHD_SF	426..469	CDD:304600	16/50 (32%)
		PHD2_MTF2_PHF19_like	514..565	CDD:276978	28/50 (56%)
		Mtf2_C	985..1032	CDD:290768	21/46 (46%)
Mtf2	XP_038948078.1	Tudor_MTF2	56..109	CDD:410521	20/61 (33%)
		PHD1_MTF2	115..167	CDD:277053	16/60 (27%)
		PHD2_MTF2	214..265	CDD:277055	28/50 (56%)
		Mtf2_C	555..602	CDD:404871	22/47 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343578
Domainoid	1	1.000	45	1.000	Domainoid score	I11886
eggNOG	1	0.900	-	-		E1_KOG4323
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	240	1.000	Inparanoid score	I3258
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001586
OrthoInspector	1	1.000	-	-		otm45590
orthoMCL	1	0.900	-	-		OOG6_109707
Panther	1	1.100	-	-	O	PTHR12628
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1484
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.750