DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pcl and Phf19

DIOPT Version :9

Sequence 1:	NP_001261067.1	Gene:	Pcl / 37069	FlyBaseID:	FBgn0003044	Length:	1043	Species:	Drosophila melanogaster
Sequence 2:	NP_001100040.1	Gene:	Phf19 / 296653	RGDID:	1310390	Length:	578	Species:	Rattus norvegicus

Alignment Length:	792	Identity:	195/792 - (24%)
Similarity:	285/792 - (35%)	Gaps:	253/792 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   277 TPQTPPTTPEAM--SSPGKSSPSPPLLATQSLLKGVNSMKPSFKTVEAAPPTPPTPPSPPPPPPA 339
            |....|.|.||.  :||.|.:||              ..|.:||.:.:
  Rat     3 TQALEPGTQEAFGATSPNKGAPS--------------KTKKNFKDLMS----------------- 36

  Fly   340 PPVAAPSPAVTYALQEDVFIKC--NDGRFYLGTI--IDQTSDQYLIRFDDQSEQWCEPDKLRKLG 400
                        .:.|..|:.|  .||.:|||.|  :.......|:.|:|.|:.|.....::.
  Rat    37 ------------KVTEGQFVLCRWTDGLYYLGKIKRVSSPKQSCLVTFEDNSKYWVLWKDIQH-- 87

  Fly   401 GGSSITAGGGGASTTESTNTSPSGPMCVAC--KRSDIEDVVEICERCGRGYHRGCTVEIVTGSG- 462
                  ||..|..           |.|..|  |.|...:.:.||.:||.|||:.|.:.|...:.
  Rat    88 ------AGVPGEE-----------PKCDVCMGKTSGPMNEILICGKCGLGYHQQCHIPIAVDANW 135

  Fly   463 ----IWSCKRCAKPMKMQQPVSHK---ITKPAGICRQ-LPYHADKLSWDEKHRVNEEQIYCYCGK 519
                .|.|:||...:.:::..:.|   |.|.....:. |.|..::|.||..||.|::|.|||||.
  Rat   136 PLLTHWFCRRCIFALAVRKGGALKKGAIAKTLQAVKMVLSYQPEELDWDSPHRTNQQQCYCYCGG 200

  Fly   520 PGKFDHNMLQCCKCRNWFHTQCMQNFKKKLLRGDMFFVFCCTVCNNGIEFVRRMQIEWVDVLHIA 584
            ||::...||||.:||.|||..|.|...:.::.||.|::|.|:|||.|.|::.|:.:.|||::|:|
  Rat   201 PGEWYLRMLQCYRCRQWFHEACTQCLSEPMVFGDRFYLFFCSVCNQGPEYIERLPLRWVDIVHLA 265

  Fly   585 LYNLRKHQHQKYHHLLNDIWPFILEQRHQLPICE--KWRTLPETALMERLKQTLKDYSDRFVCGR 647
            ||||.....::|.. ..:|..|:   .|...:.:  |..:.|.|.....|...|..|..||:||:
  Rat   266 LYNLGVQSKKRYFD-FEEILAFV---NHHWELLQLGKLTSTPVTERGPHLLNALNSYKSRFLCGK 326

  Fly   648 EFKRAPAFYALRHSGPPHIPKVFLE-----PHEELSDELLEKRFKLM--LMPEEPDEGANELPKR 705
            |.|:....:.||...||..|...|.     |.::.:.|||.||.|..  |:|:|..:....:.:|
  Rat   327 EIKKKKCIFRLRVRVPPAPPGKLLPDRAQMPSDKGTFELLRKRGKSKPGLLPQESQQQKRRVYRR 391

  Fly   706 VPKDVYEFNTDEDDPVETSEDEIPIKQIIEKAKKQAAQKADKH---------DELPLKPDLADDN 761
            .....            ..||.||....      .:|...|.|         ||:        .:
  Rat   392 KRSKF------------LLEDAIPSSDF------TSAWSTDHHLASIFDFTLDEI--------QS 430

  Fly   762 ANDGDPGKLPAPIPPLLDANSSRKRKAFRLSKRYDNSRNHCDLSSDENSSSSRGTSSLDLIIPPP 826
            ...|..|                  :.|           ..|:.|.:.:|:| |::|..|
  Rat   431 LKSGSSG------------------QTF-----------FSDVDSTDAASTS-GSASTSL----- 460

  Fly   827 VNFLGRNNPFLMATPKKASQGRSISVGTGVGVNGIINSIFKLKGTSKEQPRMVRTIKRRLSAKDI 891
                              ||....:||:.                           ||:|:||
  Rat   461 ------------------SQDSRWTVGSR---------------------------KRKLAAK-- 478

  Fly   892 TIGPNQEVRRRRTRRLTTAIEVISTTTINPIPSHYLPIYAKDLQPPAPPMGKPTHGRLLRQRPQK 956
                                             .|.|:.||  ...|.|.|:..........|
  Rat   479 ---------------------------------AYRPLRAK--HRAAEPDGRCASDSSAEGAP-- 506

  Fly   957 QSPSQSRRNSTSSTATSSSSNGIGAPGHSMLDLKQSVNKYFGGAMNRIDAGEPFAIRAKRRMGNG 1021
             .|.|......|.|..|     |.....|:..||.|:..|||.| .|:..||.:.:.|:|....|
  Rat   507 -GPEQQDEGIDSHTFES-----ISGDDSSLSHLKSSITNYFGAA-GRLACGEKYQVLARRVTPEG 564

  Fly  1022 QVQYLVEWGGDT 1033
            :||||:||.|.|
  Rat   565 KVQYLLEWEGTT 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pcl	NP_001261067.1	TUDOR	350..399	CDD:197660	14/52 (27%)
		PHD_SF	426..469	CDD:304600	15/49 (31%)
		PHD2_MTF2_PHF19_like	514..565	CDD:276978	25/50 (50%)
		Mtf2_C	985..1032	CDD:290768	20/46 (43%)
Phf19	NP_001100040.1	Tudor_PHF19	37..93	CDD:410522	16/63 (25%)
		PHD_SF	96..148	CDD:419867	17/51 (33%)
		PHD2_PHF19	195..246	CDD:277056	25/50 (50%)
		Mtf2_C	529..576	CDD:404871	21/47 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343579
Domainoid	1	1.000	45	1.000	Domainoid score	I11886
eggNOG	1	0.900	-	-		E1_KOG4323
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12524
Inparanoid	1	1.050	240	1.000	Inparanoid score	I3258
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001586
OrthoInspector	1	1.000	-	-		otm45590
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12628
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1484
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.850