Protein Alignment Pcl and Phf1

DIOPT Version :10

• Sequence 1: NP_476672.1
• Gene: Pcl / 37069
• FlyBaseID: FBgn0003044
• Length: 1043
• Species: Drosophila melanogaster
• Sequence 2: XP_017457076.1
• Gene: Phf1 / 294287
• RGDID: 1303205
• Length: 624
• Species: Rattus norvegicus
• Alignment Length: 803
• Identity: 192/803 - (23%)
• Similarity: 276/803 - (34%)
• Gaps: 271/803 - (33%)

  Fly   278 PQTPPTTPEAMSSPGKSSPSPPLLATQSLLKGVNSMKPSFKTVEAAPPTPPTPPSPPPPPPAPPV 342
            |..|...|.|...||....|||..|...|        |....:.|  |:...|.||      .|.
  Rat    40 PPRPAAPPIAQRPPGLLENSPPQDAMAQL--------PRLSRLGA--PSLWDPASP------APT 88

  Fly   343 AAPSPAVTYALQEDVFIKCNDGRFYLGTI--IDQTSDQYLIRFDDQSE---QWCEPDKLRKLGGG 402
            :.|.|.:...  :||..:..||..|||||  :|...:..|::|:|.|:   .|
  Rat    89 SGPRPRLWEG--QDVLARWTDGLLYLGTIKKVDSAREVCLVQFEDDSQFLVLW------------ 139

  Fly   403 SSITAGGGGASTTESTNTSPSG-P----MCVACKRSDIEDVVE-----ICERCGRGYHRGCTVEI 457
                           .:.||:. |    :|..|:.   |.||.     .||:|...||:.|.|..
  Rat   140 ---------------KDISPAALPGEELLCCVCRS---ETVVPGNRLVSCEKCRHAYHQDCHVPR 186

  Fly   458 VTGSG-----IWSCKRCAKPMKMQQ-------PVSHKITKPAGICRQLPYHADKLSWDEKHRVNE 510
            ....|     .|.|::|...:..::       |.:..:   .|:...|||....|.||..|..|.
  Rat   187 APAPGEGEGSSWVCRQCVFAIATKRGGALKKGPYARAM---LGMKLSLPYGLKGLDWDAGHLSNR 248

  Fly   511 EQIYCYCGKPGKFDHNMLQCCKCRNWFHTQCMQNFKKKLLRGDMFFVFCCTVCNNGIEFVRRMQI 575
            :|.|||||.||:::..||||..|..|||..|.|...|.||.||.|:.|.|.||..|.|.|||:|:
  Rat   249 QQSYCYCGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGDRFYEFECCVCRGGPEKVRRLQL 313

  Fly   576 EWVDVLHIALYNLRKHQHQKYHHLLNDIWPFILEQRHQLPICEKWRTLPETALMERLKQTLKDYS 640
            .||||.|:.||:|.....:||.....:|.||..|....|.:.|...| |:.....:|...|..:.
  Rat   314 RWVDVAHLVLYHLSVCCKKKYFDFDREILPFTSENWDSLLLGELSDT-PKGERSSKLLSALNSHK 377

  Fly   641 DRFVCGREFKRAPAFYALRHSGPPHIPKVFLEPHEELSDELLEKRFKLMLMPEEPDEGANELPKR 705
            |||:.|||.|:....:.|....||.:             |||
  Rat   378 DRFISGREIKKRKCLFGLHARTPPPV-------------ELL----------------------- 406

  Fly   706 VPKDVYEFNTDEDDPVETSEDEIP---IKQIIEKAKKQAAQKADKHDELPLKPDLADDNANDGDP 767
                     |.:..|......:.|   :.:.:.|.:|...:...:..:
  Rat   407 ---------TGDGSPTSFPSGQGPGGGVSRPLGKRRKSEPEPLRRRQK----------------- 445

  Fly   768 GKLPAPIPPLL--DANSSRKRKAFRLSKRYDNSRNHCDLSSDENSSSSRGTSSLDLIIPPPVNFL 830
            ||:....||..  ..:.|::::|.:.|:.                             |||
  Rat   446 GKVEELGPPTAAHSRHGSQEQRALQASES-----------------------------PPP---- 477

  Fly   831 GRNNPFLMATPKKASQGRSISVGTGVGVNGIINSIFKLKGTSKEQPRMVRTIKRRLSAKDITIGP 895
                    .:|.::.||.|       |.|
  Rat   478 --------PSPNQSYQGSS-------GYN------------------------------------ 491

  Fly   896 NQEVRRRRTRRLTTAIEVISTTTINPIPSHYLPIYAKDLQPPAPPMGKPTHGRLLRQRPQKQSPS 960
                              ...|....:||..:.::| ...|.|...|  |.|   ...|..:||.
  Rat   492 ------------------FRPTDARCLPSSPIRMFA-SFHPSASTAG--TSG---DSEPPDRSPL 532

  Fly   961 QSR--------RNSTSSTATSSSSNGIGAPG---HSM--LDLKQSVNKYFG----GAMNRIDAGE 1008
            :..        ::|..|...||||.....||   ||:  ..|.:|::...|    |.::.:..|:
  Rat   533 ELHIGFPTDIPKSSPHSVTASSSSVPALTPGLSRHSLPPSPLCRSLSPGTGGGVRGGVSYLSRGD 597

  Fly  1009 PFAIRAKRRMGNGQVQYLVEWGG 1031
            |..:.|:|...:|.|||||||||
  Rat   598 PVRVLARRVRPDGSVQYLVEWGG 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pcl	NP_476672.1	PRK12323	<13..107	CDD:481241
		Tudor_dPCL-like	350..401	CDD:410523	15/55 (27%)
		PHD_SF	426..469	CDD:473978	15/52 (29%)
		PHD2_MTF2_PHF19_like	514..565	CDD:276978	27/50 (54%)
		Mtf2_C	985..1033	CDD:464077	19/53 (36%)
Phf1	XP_017457076.1	Tudor_PHF1	94..146	CDD:410520	17/80 (21%)
		PHD1_PHF1	153..203	CDD:276975	15/52 (29%)
		PHD2_PHF1	252..303	CDD:277057	27/50 (54%)
		Mtf2_C	<593..622	CDD:464077	14/28 (50%)