DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pcl and Phf1

DIOPT Version :9

Sequence 1:	NP_001261067.1	Gene:	Pcl / 37069	FlyBaseID:	FBgn0003044	Length:	1043	Species:	Drosophila melanogaster
Sequence 2:	NP_033369.2	Gene:	Phf1 / 21652	MGIID:	98647	Length:	559	Species:	Mus musculus

Alignment Length:	750	Identity:	186/750 - (24%)
Similarity:	264/750 - (35%)	Gaps:	256/750 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 PSPPPPPPAPPVAAPSPAVTYALQEDVFIKCNDGRFYLGTI--IDQTSDQYLIRFDDQSE---QW 390
            ||...|....|.:.|.|.:...  :||..:..||..|||||  :|...:..|::|:|.|:   .|
Mouse    13 PSLWDPASPAPTSGPRPRLWEG--QDVLARWTDGLLYLGTIKKVDSAREVCLVQFEDDSQFLVLW 75

  Fly   391 CEPDKLRKLGGGSSITAGGGGASTTESTNTSPSG-P----MCVACKRSDIEDVVE-----ICERC 445
                                       .:.||:. |    :|..|:.   |.||.     .||:|
Mouse    76 ---------------------------KDISPAALPGEELLCCVCRS---ETVVPGNRLVSCEKC 110

  Fly   446 GRGYHRGCTVEIVTGSG-----IWSCKRCAKPMKMQQ-------PVSHKITKPAGICRQLPYHAD 498
            ...||:.|.|......|     .|.|::|...:..::       |.:..:   .|:...|||...
Mouse   111 RHAYHQDCHVPRAPAPGEGEGASWVCRQCVFAIATKRGGALKKGPYARAM---LGMKLSLPYGLK 172

  Fly   499 KLSWDEKHRVNEEQIYCYCGKPGKFDHNMLQCCKCRNWFHTQCMQNFKKKLLRGDMFFVFCCTVC 563
            .|.||..|..|.:|.|||||.||:::..||||..|..|||..|.|...|.||.||.|:.|.|.||
Mouse   173 GLDWDAGHLSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGDRFYEFECCVC 237

  Fly   564 NNGIEFVRRMQIEWVDVLHIALYNLRKHQHQKYHHLLNDIWPFILEQRHQLPICEKWRTLPETAL 628
            ..|.|.|||:|:.||||.|:.||:|.....:||.....:|.||..|....|.:.|    |.:|..
Mouse   238 RGGPEKVRRLQLRWVDVAHLVLYHLSVCCKKKYFDFDREILPFTSENWDSLLLGE----LSDTPK 298

  Fly   629 MERLKQ---TLKDYSDRFVCGREFKRAPAFYALRHSGPPHIPKVFLEPHEELSDELLEKRFKLML 690
            .||..|   .|..:.|||:.|||.|:....:.|....||        |.|.|:.:.....|.
Mouse   299 GERSSQLLSALNSHKDRFISGREIKKRKCLFGLHARTPP--------PVELLTGDGAPTSFP--- 352

  Fly   691 MPEEPDEGANE-LPKRVPKDVYEFNTDEDDPVETSEDEIPIKQIIEKAKKQAAQKADKHDELPLK 754
            ..:.|..|.:. |.||                ..||.| |:::         .||
Mouse   353 SGQGPGGGVSRPLGKR----------------WRSEPE-PLRR---------RQK---------- 381

  Fly   755 PDLADDNANDGDPGKLPAPIPPLL--DANSSRKRKAFRLSKRYDNSRNHCDLSSDENSSSSRGTS 817
                         ||:....||..  ..:.||:::|.:.|
Mouse   382 -------------GKVEELGPPTAAHSRHGSREQRALQAS------------------------- 408

  Fly   818 SLDLIIPPPVNFLGRNNPFLMATPKKASQGRSISVGTGVGVNGIINSIFKLKGTSKEQPRMVRTI 882
                :.|||            .:|.::.:|.|       |.|
Mouse   409 ----VSPPP------------PSPNQSYEGSS-------GYN----------------------- 427

  Fly   883 KRRLSAKDITIGPNQEVRRRRTRRLTTAIEVISTTTINPIPSHYLPIYAKDLQPPAPPMGKPTHG 947
                                           ...|....:||..:.::| ...|.|...|  |.|
Mouse   428 -------------------------------FRPTDARCLPSSPIRMFA-SFHPSASTAG--TSG 458

  Fly   948 RLLRQRPQKQS--------PSQSRRNSTSSTATSSSSNGIGAPGHSM----LDLKQSVNKYFG-- 998
               ...|..:|        |:.:.::|..|...||||.....||.|.    ..|.:|::...|
Mouse   459 ---DSEPPDRSPLGLHIGFPTDTPKSSPHSVTASSSSVPALTPGFSRHSPPSPLCRSLSPGTGGG 520

  Fly   999 --GAMNRIDAGEPFAIRAKRRMGNGQVQYLVEWGG 1031
              |.::.:..|:|..:.|:|...:|.|||||||||
Mouse   521 VRGGVSYLSRGDPVRVLARRVRPDGSVQYLVEWGG 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pcl	NP_001261067.1	TUDOR	350..399	CDD:197660	15/53 (28%)
		PHD_SF	426..469	CDD:304600	15/52 (29%)
		PHD2_MTF2_PHF19_like	514..565	CDD:276978	27/50 (54%)
		Mtf2_C	985..1032	CDD:290768	18/54 (33%)
Phf1	NP_033369.2	TUDOR	29..80	CDD:197660	16/79 (20%)
		PHD1_PHF1	89..139	CDD:276975	15/52 (29%)
		PHD2_PHF1	188..239	CDD:277057	27/50 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..434		32/249 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..526		21/82 (26%)
		Mtf2_C	<531..556	CDD:290768	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839741
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4323
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3299
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001586
OrthoInspector	1	1.000	-	-		otm43523
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12628
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6663
SonicParanoid	1	1.000	-	-		X1484
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.880