DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pcl and Mtf2

DIOPT Version :9

Sequence 1:	NP_001261067.1	Gene:	Pcl / 37069	FlyBaseID:	FBgn0003044	Length:	1043	Species:	Drosophila melanogaster
Sequence 2:	NP_001346017.1	Gene:	Mtf2 / 17765	MGIID:	105050	Length:	604	Species:	Mus musculus

Alignment Length:	738	Identity:	189/738 - (25%)
Similarity:	270/738 - (36%)	Gaps:	229/738 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   344 APSPAVTYALQEDVFIKCNDGRFYLGTI--IDQTSDQYLIRFDDQSEQWCEPDKLRKLGGGSSIT 406
            |..||..:...:||..:.:||.||||||  |:.......|.|:|.|:.|.    |.|     .|.
Mouse    50 AKKPACKFEEGQDVLARWSDGLFYLGTIKKINILKQSCFIIFEDSSKSWV----LWK-----DIQ 105

  Fly   407 AGGGGASTTESTNTSPSGPM-CVACKR--SDIEDVVEICERCGRGYHRGCTVEIVTGSGI----- 463
            .|..|           ||.| |..|:.  |:..:.:.||::||:|||:.|....:..|.|
Mouse   106 TGATG-----------SGEMVCTICQEEYSEAPNEMVICDKCGQGYHQLCHTPHIDSSVIDSDEK 159

  Fly   464 WSCKRCAKPMKMQQPVSHKITKPAGICRQ-------------LPYHADKLSWDEKHRVNEEQIYC 515
            |.|::|         |....||..|..::             |||....|.||..|:.|.:|.||
Mouse   160 WLCRQC---------VFATTTKRGGALKKGPNAKALQVMKQTLPYSVADLEWDAGHKTNVQQCYC 215

  Fly   516 YCGKPGKFDHNMLQCCKCRNWFHTQCMQNFKKKLLRGDMFFVFCCTVCNNGIEFVRRMQIEWVDV 580
            |||.||.:...|||||||:.|||..|:|..:|.:|.||.|:.|.|:||::|.|:::|:.::|||:
Mouse   216 YCGGPGDWYLKMLQCCKCKQWFHEACVQCLQKPMLFGDRFYTFICSVCSSGPEYLKRLPLQWVDI 280

  Fly   581 LHIALYNLRKHQHQKYHHLLNDIWPFILEQRHQLPICEKWRTL--------PETALMERLKQTLK 637
            .|:.||||.....:||         |..|......|.|.|..|        |::...|.:.:.|.
Mouse   281 AHLCLYNLSVIHKKKY---------FDSELELMTYINENWDRLHPGELADTPKSERYEHVLEALN 336

  Fly   638 DYSDRFVCGREFKRAPAFYALRHSGPPHIPKVFLEPHEELSDELLEKRFKLMLMPEEPDEGANEL 702
            ||...|:.|:|.|:....:.||...||..|.|               .||    .|:..||.:
Mouse   337 DYKTMFMSGKEIKKKKHLFGLRIRVPPVPPNV---------------AFK----AEKEPEGTS-- 380

  Fly   703 PKRVPKDVYEFNTDEDDPVETSEDEIPIKQIIEKAKKQAA----------QKADKHDELPLKPDL 757
                    :||........:.:.|...:...|||..|:.:          :...|..||||..:.
Mouse   381 --------HEFKIKGRKASKPTSDSREVSNGIEKKGKKKSVGRPPGPYTRKMIQKTAELPLDKES 437

  Fly   758 ADDNANDGDPGKLPAPIPPLLDANSSRKRKAFRLSKRYDNSRNHCDLSSDENSSSSRGTSSLDLI 822
            ..:|              |.||.                    .|.:...|..:.|..||.:|
Mouse   438 VSEN--------------PTLDL--------------------PCSIGRTEGIAHSSNTSDVD-- 466

  Fly   823 IPPPVNFLGRNNPFLMATPKKASQGRSISVGTGVGVNGIINSIFKLKGTSKEQPRMVRTIKRRLS 887
                                                         |.|.|........:|.|...
Mouse   467 ---------------------------------------------LTGASSANETTSASISRHCG 486

  Fly   888 AKDITIGPNQEVRRRRTRRLTTAIEVISTTTINPIPSHYLPIYAKDLQPPAPPMGKPTHGRLLRQ 952
            ..|         .|:|||...:                         .|.|.|..:...|||.|:
Mouse   487 LSD---------SRKRTRTGRS-------------------------WPAAIPHLRRRRGRLPRR 517

  Fly   953 RPQKQS-----PSQSRRNSTSSTATSSSSNGIGAPGHSMLDLKQSVNKYFGGAMNRIDAGEPFAI 1012
            ..|.|:     ..:.:.:.......:...|.:......:..||.|:..|||.| .||..||.:.:
Mouse   518 ALQTQNSEVVKDDEGKEDYQFEELNTEILNNLADQELQLNHLKNSITSYFGAA-GRIACGEKYRV 581

  Fly  1013 RAKRRMGNGQVQYLVEWGGDTAT 1035
            .|:|...:|:|||||||.|.||:
Mouse   582 LARRVTLDGKVQYLVEWEGATAS 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pcl	NP_001261067.1	TUDOR	350..399	CDD:197660	17/50 (34%)
		PHD_SF	426..469	CDD:304600	16/50 (32%)
		PHD2_MTF2_PHF19_like	514..565	CDD:276978	28/50 (56%)
		Mtf2_C	985..1032	CDD:290768	21/46 (46%)
Mtf2	NP_001346017.1	Tudor_MTF2	56..109	CDD:410521	20/61 (33%)
		PHD1_MTF2	115..167	CDD:277053	16/60 (27%)
		PHD2_MTF2	214..265	CDD:277055	28/50 (56%)
		Mtf2_C	555..602	CDD:404871	22/47 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839739
Domainoid	1	1.000	45	1.000	Domainoid score	I12135
eggNOG	1	0.900	-	-		E1_KOG4323
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3299
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001586
OrthoInspector	1	1.000	-	-		otm43523
orthoMCL	1	0.900	-	-		OOG6_109707
Panther	1	1.100	-	-	O	PTHR12628
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6663
SonicParanoid	1	1.000	-	-		X1484
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.780