Protein Alignment Hsf and HSFY1

DIOPT Version :10

• Sequence 1: NP_001036555.1
• Gene: Hsf / 37068
• FlyBaseID: FBgn0001222
• Length: 733
• Species: Drosophila melanogaster
• Sequence 2: NP_149099.2
• Gene: HSFY1 / 86614
• HGNCID: 18568
• Length: 401
• Species: Homo sapiens
• Alignment Length: 354
• Identity: 93/354 - (26%)
• Similarity: 143/354 - (40%)
• Gaps: 77/354 - (21%)

  Fly    49 FLAKLWRLVDDADTNRLICWTKDGQSFVIQNQAQFAKELLPLN-----YKHNNMASFIRQLNMYG 108
            |..|||::| ::|..:.|.|.::|...|| |:..|.||:|...     ::.:.:.||:||||:||
Human    80 FPRKLWKIV-ESDQFKSISWDENGTCIVI-NEELFKKEILETKAPYRIFQTDAIKSFVRQLNLYG 142

  Fly   109 FHKITSIDNGGLRFDR---------DEIEFS---------HPFFKRNSPFLLDQIKRKISNNKNG 155
            |.||..      .|.|         :|.|.|         :|.|||..|.||.::||:| ..||.
Human   143 FSKIQQ------NFQRSAFLATFLSEEKESSVLSKLKFYYNPNFKRGYPQLLVRVKRRI-GVKNA 200

  Fly   156 DDKGVLKPEAMSKILTDVKVMR------------GRQDNLDSRFSAMKQENEVLWREIASLRQKH 208
            .....|..|..:|     |..|            ..:.:.:|.|||.|..|..|.|| :|:|
Human   201 SPISTLFNEDFNK-----KHFRAGANMENHNSALAAEASEESLFSASKNLNMPLTRE-SSVR--- 256

  Fly   209 AKQQQIVNKLIQFLITIVQPSRNMSGVKRHVQLMINNTPEIDRARTTSETESES----GGGPVIH 269
               |.|.|..:........||.:.| |....|:..:....:::. ||....|.|    ..|.:::
Human   257 ---QIIANSSVPIRSGFPPPSPSTS-VGPSEQIATDQHAILNQL-TTIHMHSHSTYMQARGHIVN 316

  Fly   270 ELREELLD-EVMNPSPAGYTAASHYDQESVSPPAVERPRSNMSISSHNVDYSNQSVEDLLLQGNG 333
            .:...... .:::|...||...      :|.|.||  |.....:|.:...|.|     :|..||.
Human   317 FITTTTSQYHIISPLQNGYFGL------TVEPSAV--PTRYPLVSVNEAPYRN-----MLPAGNP 368

  Fly   334 TAGGNILVGGAASPMAQSVSQSPAQHDVY 362
            ......:...:|:|.::...| |:..|.|
Human   369 WLQMPTIADRSAAPHSRLALQ-PSPLDKY 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsf	NP_001036555.1	HSF	45..148	CDD:214654	40/121 (33%)
		Vert_HS_TF	<579..711	CDD:461944
HSFY1	NP_149099.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30
		HSF_DNA-bind	80..194	CDD:459813	40/121 (33%)