DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsf and SFL1

DIOPT Version :9

Sequence 1:	NP_001036555.1	Gene:	Hsf / 37068	FlyBaseID:	FBgn0001222	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_014783.4	Gene:	SFL1 / 854307	SGDID:	S000005666	Length:	766	Species:	Saccharomyces cerevisiae

Alignment Length:	836	Identity:	169/836 - (20%)
Similarity:	272/836 - (32%)	Gaps:	309/836 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 YGDAAAIGSGVP---AFLAKLWRLVDDADTNRLICWTKDGQSFVIQNQAQFAKELLPLNYKHNNM 97
            :|....:|...|   .|:.||:::::|...:.||.||..|.||:|:...:|:|.|... :||.|:
Yeast    49 HGSKMLVGPRPPQNAIFIHKLYQILEDESLHDLIWWTPSGLSFMIKPVERFSKALATY-FKHTNI 112

  Fly    98 ASFIRQLNMYGFHKI----------------------TSIDNGGLR-FDRDE------------- 126
            .||:||||:|||||:                      |..||.|.: ...||
Yeast   113 TSFVRQLNIYGFHKVSHDHSSNDANSGDDANTNDDSNTHDDNSGNKNSSGDENTGGGVQEKEKSN 177

  Fly   127 ----IEFSHP--FFKRNSPFLLDQIK-------------RKISNNKNGD-DKGV-LKPEAMSKIL 170
                .||.|.  .||:.....|..||             ||.|:|:|.| |.|. ::|.::....
Yeast   178 PTKIWEFKHSSGIFKKGDIEGLKHIKRRASSRNNSSINSRKNSSNQNYDIDSGARVRPSSIQDPS 242

  Fly   171 TD-------VKVMRGRQDN-------------------LDSRFSAMKQEN-------EVLWREIA 202
            |.       |..:.|..::                   |:|....|:::|       |.|
Yeast   243 TSSNSFGNFVPQIPGANNSIPEYFNNSHVTYENANHAPLESNNPEMQEQNRPPNFQDETL----- 302

  Fly   203 SLRQKHAKQ-----QQIVNKLIQFL----------ITIVQPSR-------------------NMS 233
                ||.|:     .:|:..:..|:          .|....|:                   :|.
Yeast   303 ----KHLKEINFDMVKIIESMQHFISLQHSFCSQSFTFKNVSKKKSENIVKDHQKQLQAFESDML 363

  Fly   234 GVKRHVQLMINNTPEIDRARTTSETESESGGGPVIHELREELLDEVMNPSP---AGYTAASHYDQ 295
            ..|:||....:.|  ||.....:...:.:...|.              |:|   :.|...|.|
Yeast   364 TFKQHVMSRAHRT--IDSLCAVNAAATAASVAPA--------------PAPTSTSAYAPKSQY-- 410

  Fly   296 ESVSPPAVER-PRSNMSISSHNVDYSNQSV--EDLLLQGNGTAGGNILVGGAASPMAQSVSQSPA 357
            |.:.||..:. |:.:.|.::....::..||  ..|.:|              ..|.:|
Yeast   411 EMMVPPGNQYVPQKSSSTTNIPSRFNTASVPPSQLFVQ--------------YQPQSQ------- 454

  Fly   358 QHDVYTVTEA--PDSHVQEVP--NSPPYYEEQNVLTTPMVREQEQQKRQQLKENNKLRRQAGDVI 418
            ||..|....|  |:...|.:|  ..||.|.:  ..:||.:.......:...|..|..|
Yeast   455 QHVTYAKQPAHVPNFINQPIPIQQLPPQYAD--TFSTPQMMHNPFASKNNNKPGNTKR------- 510

  Fly   419 LDAGDILVDSSSPKAQRTSIQHSTQPDVM-VQPMI---IKSEPEN--SSGLMDLMTPANDLYSVN 477
              ...:|:|..:|.|. ..:|......:| :.|.:   .|..|:|  .|.:..:..|...|||..
Yeast   511 --TNSVLMDPLTPAAS-VGVQGPLNYPIMNINPSVRDYNKPVPQNMAPSPIYPINEPTTRLYSQP 572

  Fly   478 FI-----SEDMPTD-------------IFEDALLPDGVEEAAKLDQQQKFGQSTVSSGKFASNFD 524
            .:     :..:|.|             :.||:|.|          :.:...:|::|....:|:|.
Yeast   573 KMRSLGSTSSLPNDRRNSPLKLTPRSSLNEDSLYP----------KPRNSLKSSISGTSLSSSFT 627

  Fly   525 VPTNSTLLDANQASTSKAAAKAQASEEEGMAVAKYSGAENGNNRDTNNSQLLRMASVLVDQKNTN 589
            :..|:.                        |..:||  :.|         |||
Yeast   628 LVANNP------------------------APIRYS--QQG---------LLR------------ 645

  Fly   590 SSRISHNQAANSYCCSDE--------LHGHLESMQDELETLKDLLRGDGVAIDQNMLMGALSRTP 646
                |.|:|||  |..|.        |.|......|.|..:...|....:.::.:..:......|
Yeast   646 ----SLNKAAN--CAPDSVTPLDSSVLTGPPPKNMDNLPAVSSNLINSPMNVEHSSSLSQAEPAP 704

  Fly   647 NFQLPEDEL-LLKLFNDSDLMDN--------YGLSFPNDSISS-------EKKAPS 686
            ..:||:..| ......::...||        |.|....||.:|       :|.||:
Yeast   705 QIELPQPSLPTTSTTKNTGEADNSKRKGSGVYSLLNQEDSSTSSADPKTEDKAAPA 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsf	NP_001036555.1	HSF	45..148	CDD:214654	44/160 (28%)
Hsf	NP_001036555.1	Vert_HS_TF	<607..711	CDD:284062	19/104 (18%)
SFL1	NP_014783.4	HSF1	53..381	CDD:227497	77/339 (23%)
SFL1	NP_014783.4	PHA03247	<540..722	CDD:223021	43/244 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5169
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2153
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.890