DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsf and MGA1

DIOPT Version :9

Sequence 1:	NP_001036555.1	Gene:	Hsf / 37068	FlyBaseID:	FBgn0001222	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_011765.1	Gene:	MGA1 / 853164	SGDID:	S000003481	Length:	456	Species:	Saccharomyces cerevisiae

Alignment Length:	542	Identity:	120/542 - (22%)
Similarity:	211/542 - (38%)	Gaps:	170/542 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 FLAKLWRLVDDADTNRLICW--TKDGQSFVIQNQAQFAKELLPLNYKHNNMASFIRQLNMYGFHK 111
            |:.:|..::.:.:.|:.|.|  |.:...|:......|:..:|...:||.|:.||:|||:||||||
Yeast     6 FVHQLHAILLEPEVNKWIYWSPTDNTVFFLKPYDPNFSTHVLKRYFKHGNVNSFVRQLHMYGFHK 70

  Fly   112 I-------TSIDNGGLRFDRDEIEFSHP---FFKRNSPFLLDQIKRKISN-NKNGDDKGVLKPEA 165
            :       :|.:||.:: :..|.:|:||   |||..:..:|::|:||.:. .|:|..|.:|.|.:
Yeast    71 LSHPSPDQSSANNGNVK-ELVEWKFTHPSGFFFKEANAGILNKIQRKSTGVGKDGKRKNILSPIS 134

  Fly   166 MSKILTDVKVMRGRQDNLDSRFSAMKQENEVLWREIASLRQKHAKQQQIVNKLIQFLITIVQPSR 230
            :|.:  |.           ||.:.:.|::..                          ::..:||.
Yeast   135 VSYV--DA-----------SRLNVLSQQSGP--------------------------VSAREPSN 160

  Fly   231 NMSGVKRHVQLMINNTPEIDRARTTSETESESGGGPVIHELREELLDEVMNPSPAGYTAASHYDQ 295
            ...|...|.... .:.|.|      |..:.:...||                    |..:|
Yeast   161 MFMGSPVHYSTS-QSPPHI------SIPQQQQSSGP--------------------YLISS---- 194

  Fly   296 ESVSPPAVERPRSNM----SISS---HNVDYSNQ-SVEDLLLQGNGTAGGNILVGGAASPMAQSV 352
               .||  ::|..||    |||:   ::.||.|| |.:|.::|.....  .:|     ||.|.|
Yeast   195 ---LPP--QQPTVNMMRRQSISARMMNSYDYPNQFSTQDSIVQPQQPQ--QVL-----SPQALS- 246

  Fly   353 SQSPAQHDVYTVTEAPDSHVQEVP--NSP-PYYEEQNVLTTPMVREQEQQKRQQLKEN------- 407
              .|......|::...|.....:|  |.| ||:        |....|:||::||....
Yeast   247 --GPPMKKSGTLSSTDDLKTTSLPIVNYPMPYH--------PGAFAQQQQQQQQPLPTVPPYSSY 301

  Fly   408 --------NKLRRQAGD---VILDAGDILVDSSSPKAQRTSIQH---------STQPDVMVQPMI 452
                    |.|...|.:   :.:...::.:...|..::|.::.:         ||..|::.:.:.
Yeast   302 STPFPSMMNSLSNSASNSPALGVCNNNVTLPKKSNISERQALDNHIQTLKNSLSTITDLIEKHIN 366

  Fly   453 IKSEPENSSGLMDLMTPANDLYSVNFISEDMPTDIFEDALLPDGVEEAAKLDQQQKFGQSTVSSG 517
            ..|:.||.       |..||.     :::|:.|.:   :||.:..||..:|:.:....||..::.
Yeast   367 SASQDENK-------TLTNDA-----MNKDLRTSL---SLLQNSKEEIIQLESKWMSMQSVKTTA 416

  Fly   518 KFASNFDVPTNSTLLDANQAST 539
                   :|...|   .|.:||
Yeast   417 -------LPLQET---TNTSST 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsf	NP_001036555.1	HSF	45..148	CDD:214654	35/110 (32%)
Hsf	NP_001036555.1	Vert_HS_TF	<607..711	CDD:284062
MGA1	NP_011765.1	HSF_DNA-bind	1..>156	CDD:416433	47/189 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2153
SonicParanoid	1	1.000	-	-		X160
TreeFam	1	0.960	-	-
	5	4.800