DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsf and HSF1

DIOPT Version :9

Sequence 1:	NP_001036555.1	Gene:	Hsf / 37068	FlyBaseID:	FBgn0001222	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_011442.3	Gene:	HSF1 / 852806	SGDID:	S000003041	Length:	833	Species:	Saccharomyces cerevisiae

Alignment Length:	648	Identity:	140/648 - (21%)
Similarity:	259/648 - (39%)	Gaps:	138/648 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PAFLAKLWRLVDDADTNRLICWTKDGQSFVIQNQAQFAKELLPLNYKHNNMASFIRQLNMYGFHK 111
            |||:.|||.:::|....:||.|.:||:||::.|:.:|..::||..:||:|.|||:|||||||:||
Yeast   173 PAFVNKLWSMLNDDSNTKLIQWAEDGKSFIVTNREEFVHQILPKYFKHSNFASFVRQLNMYGWHK 237

  Fly   112 ITSIDNGGLRFDRDE-IEFSHPFFKRNSPFLLDQ-IKRKISNNKNGDDKGVLKP----------- 163
            :..:.:|.::...|: .:|.:..|.|....||:: |::|.|:|.:....|...|
Yeast   238 VQDVKSGSIQSSSDDKWQFENENFIRGREDLLEKIIRQKGSSNNHNSPSGNGNPANGSNIPLDNA 302

  Fly   164 --------------------------------EA-------MSKILTDVKVMRGRQDNLDSRFSA 189
                                            ||       ::.||.:::.::..|..:......
Yeast   303 AGSNNSNNNISSSNSFFNNGHLLQGKTLRLMNEANLGDKNDVTAILGELEQIKYNQIAISKDLLR 367

  Fly   190 MKQENEVLWREIASLRQKHAKQQQIVNKLIQFLITIV---QPSRNMSGVKRHVQLMINNTPEIDR 251
            :.::||:||:|....|::|..|||.:.|:.:||.:||   .|...|.|:.   ...:|| .:::.
Yeast   368 INKDNELLWQENMMARERHRTQQQALEKMFRFLTSIVPHLDPKMIMDGLG---DPKVNN-EKLNS 428

  Fly   252 ARTTSETESESGGGPVIHELREELLDEVMNPSPAGYTAASHYDQESVSP----PAVERPRSNMSI 312
            |.........:|   .|.||:..  |..:|.....:|.|:...:.::||    .:::...:|.:.
Yeast   429 ANNIGLNRDNTG---TIDELKSN--DSFINDDRNSFTNATTNARNNMSPNNDDNSIDTASTNTTN 488

  Fly   313 SSHNVD----YSNQSVEDLLL-----------QGNGTAGGNI-------LVGGAASPMAQSVSQS 355
            ...|:|    .:|..:.|::.           ..|..||..|       |:...|:....|.:.|
Yeast   489 RKKNIDENIKNNNDIINDIIFNTNLANNLSNYNSNNNAGSPIRPYKQRYLLKNRANSSTSSENPS 553

  Fly   356 PAQHDVYT-----VTEAP--DSHVQEVPNSPPYYEEQNVLTT---------PMVREQEQQKRQQL 404
            ....|:.:     ::|.|  |...:|....|....:.|..|:         .|:.:.:.:|....
Yeast   554 LTPFDIESNNDRKISEIPFDDEEEEETDFRPFTSRDPNNQTSENTFDPNRFTMLSDDDLKKDSHT 618

  Fly   405 KENNKLRRQAGDVILDAGDILVDSSSPKAQR-TSIQHSTQPDVMVQPMIIKSEPENSSGLMDLMT 468
            .:|   :....|:..|.....:|....:.|. .::.|...|....:....|:...|::..|:...
Yeast   619 NDN---KHNESDLFWDNVHRNIDEQDARLQNLENMVHILSPGYPNKSFNNKTSSTNTNSNMESAV 680

  Fly   469 PANDLYSVNFISEDMPTDIFEDALLPDGVEEAAKLDQQQKFGQSTVSSGKFASNFDVPTNSTLLD 533
            ..|   |..|..:|..|.   ::..|:.|             .|..|:|..::...:|.::   |
Yeast   681 NVN---SPGFNLQDYLTG---ESNSPNSV-------------HSVPSNGSGSTPLPMPNDN---D 723

  Fly   534 ANQASTSKAAAKAQASEEEGMAVAKYSGAENGNNRDTNNSQLLRMASVLVDQKNTNSSRISHN 596
            ...||||....      |.|..:..:...::....|.|.|:.....|..:....|.::::|.|
Yeast   724 TEHASTSVNQG------ENGSGLTPFLTVDDHTLNDNNTSEGSTRVSPDIKFSATENTKVSDN 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsf	NP_001036555.1	HSF	45..148	CDD:214654	41/102 (40%)
Hsf	NP_001036555.1	Vert_HS_TF	<607..711	CDD:284062
HSF1	NP_011442.3	HSF1	165..453	CDD:227497	77/288 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345846
Domainoid	1	1.000	91	1.000	Domainoid score	I1753
eggNOG	1	0.900	-	-		E1_COG5169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000255
OrthoInspector	1	1.000	-	-		oto99957
orthoMCL	1	0.900	-	-		OOG6_101482
Panther	1	1.100	-	-	LDO	PTHR10015
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2153
SonicParanoid	1	1.000	-	-		X160
TreeFam	1	0.960	-	-
	11	10.730