DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsf and HSFC1

DIOPT Version :9

Sequence 1:	NP_001036555.1	Gene:	Hsf / 37068	FlyBaseID:	FBgn0001222	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_189095.1	Gene:	HSFC1 / 822047	AraportID:	AT3G24520	Length:	330	Species:	Arabidopsis thaliana

Alignment Length:	370	Identity:	86/370 - (23%)
Similarity:	144/370 - (38%)	Gaps:	97/370 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 VPAFLAKLWRLVDDADTNRLICWTKDGQSFVIQNQAQFAKELLPLNYKHNNMASFIRQLNMYGFH 110
            :..|:.|.:::|:|..|:.||.|.....||::.:...|::.:||..:||||.:||:||||.|||.
plant    15 IAPFIVKTYQMVNDPSTDWLITWGPAHNSFIVVDPLDFSQRILPAYFKHNNFSSFVRQLNTYGFR 79

  Fly   111 KITSIDNGGLRFDRDEIEFSHPFFKRNSPFLLDQI-KRKISNNKNGDDKGVLKPEAMSKILTDVK 174
            |:          |.|..||::..|.|....||:.| :||.:....|.|            |.|.:
plant    80 KV----------DPDRWEFANEHFLRGQKHLLNNIARRKHARGMYGQD------------LEDGE 122

  Fly   175 VMRGRQDNLDSRFSAMKQENEVLWREIASLRQKHAKQQQIVNKLIQFLITIVQ-----PSRNMSG 234
            ::|        ....:|:|...|..||..:.::....::...:::.||..:|:     |...:..
plant   123 IVR--------EIERLKEEQRELEAEIQRMNRRIEATEKRPEQMMAFLYKVVEDPDLLPRMMLEK 179

  Fly   235 VKRHVQLMINNTPEIDRARTTSETESESGGGPVIHELREELLDE-------VM------------ 280
            .:...|..:::..:  |..|.|..:||           ||.::|       ||
plant   180 ERTKQQQQVSDKKK--RRVTMSTVKSE-----------EEEVEEDEGRVFRVMSSSTPSPSSTEN 231

  Fly   281 ---NPSPAGYTAA------SHYDQESVSPPAVERPRSNMSISSHNVDYSNQSVEDLLLQGNGTAG 336
               |.||.|:...      ..|:...|:       :|.:|.|:.:...|..|...|....||..|
plant   232 LYRNHSPDGWIVPMTQGQFGSYETGLVA-------KSMLSNSTSSTSSSLTSTFSLPESVNGGGG 289

  Fly   337 GNILVGGAASPMAQSVSQSPAQHDVYTVTEAPDSHVQEVPNSPPY 381
            |.          ..|:.......:..|.....:|:   .|.:|||
plant   290 GG----------CGSIQGERRYKETATFGGVVESN---PPTTPPY 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsf	NP_001036555.1	HSF	45..148	CDD:214654	36/102 (35%)
Hsf	NP_001036555.1	Vert_HS_TF	<607..711	CDD:284062
HSFC1	NP_189095.1	HSF	16..107	CDD:214654	36/100 (36%)
HSFC1	NP_189095.1	DUF5401	<105..>195	CDD:375164	17/111 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	93	1.000	Domainoid score	I2555
eggNOG	1	0.900	-	-		E1_COG5169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1154048at2759
OrthoFinder	1	1.000	-	-		FOG0000255
OrthoInspector	1	1.000	-	-		otm2595
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10015
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X160
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.880