DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsf and si:dkey-18a10.3

DIOPT Version :9

Sequence 1:	NP_001036555.1	Gene:	Hsf / 37068	FlyBaseID:	FBgn0001222	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	XP_001332195.3	Gene:	si:dkey-18a10.3 / 792628	ZFINID:	ZDB-GENE-091204-174	Length:	424	Species:	Danio rerio

Alignment Length:	482	Identity:	139/482 - (28%)
Similarity:	229/482 - (47%)	Gaps:	105/482 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 VPAFLAKLWRLVDDADTNRLICWTKDGQSFVIQNQAQFAKELLPLNYKHNNMASFIRQLNMYGFH 110
            ||||::|||.||:...||.||||::||.||::|::.:|:||:|||.:||:||.||:|||||||||
Zfish     4 VPAFVSKLWTLVEAQATNHLICWSQDGCSFLVQDEQRFSKEVLPLYFKHSNMTSFVRQLNMYGFH 68

  Fly   111 KITSIDNGGLRFDRDE-----IEFSHPFFKRNSPFLLDQIKRKISNNKNGDDKGVLKPEAMSKIL 170
            |:..:|:|   ..:.|     :||.|..|:|:.|.||..|:||:|.::..::.|     .||:::
Zfish    69 KVLHVDSG---LPKAESQINCVEFQHEDFQRDQPHLLGLIRRKVSVSRGAEEGG-----QMSQVI 125

  Fly   171 TDVKVMRGRQDNLDSRFSAMKQENEVLWREIASLRQKHAKQQQIVNKLIQFLITIVQPSRNMSGV 235
            ..|:..||.||:.|.:.:|:.::||.||||:.:|||.:.:|.:|:.|:|:|:|..|| ...:.|.
Zfish   126 VQVRHFRGCQDSSDLKLTALCRDNESLWRELDTLRQNYQQQHKIIRKIIKFIINSVQ-LNGIKGC 189

  Fly   236 KRHVQLMINNTPE------------IDRARTTS---------ETESES----GGGPVIHELREEL 275
            ||.:. ||:|:.|            ::...|||         |.:..|    ..|.:|.:: .:|
Zfish   190 KRRLP-MIDNSGEFHSAPKYARSFGVNSTLTTSCLQENPSLQELDVSSADVYSNGMIISDI-TDL 252

  Fly   276 LDEVMNPSPAGYTAASHYDQESVSPPA-VERPRSNMSISSHNVDYSNQSVEDLLLQGNGTAGGNI 339
            ||.....:....|........:.|||| ...|..::::|..|        :.::|:...||
Zfish   253 LDPTPELNRGCMTECLPEILPTFSPPASPSMPSMDLALSFLN--------DPVVLESEETA---- 305

  Fly   340 LVGGAASPMAQSVSQSPAQHDVYTVTEAPDSHVQEV----PNSPPYYEEQNVLTTP-----MVRE 395
                            ..::||.......||.::.:    |.|||..:..:.:.:|     ..:.
Zfish   306 ----------------QERNDVCDPLALIDSSLEAIRSCSPPSPPDLDNFSKILSPGCHISAAKV 354

  Fly   396 QEQQKRQQLKENNKLRRQAGDVILDAGDILVDSSSPKAQRTSIQHSTQPDVMVQPMIIKSEPENS 460
            .|.::..|.:||.                 |.......|.|.:|.....|         .:.|.|
Zfish   355 TESKQESQNEENT-----------------VTHQRSLQQHTDLQQEHCDD---------DDGEFS 393

  Fly   461 SGLMDLMTPANDLYSVNFISEDMPTDI 487
            ..|..|:..|.:..|::|.:..:|.:|
Zfish   394 DILPSLLQLAQEASSLSFSNTILPLEI 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsf	NP_001036555.1	HSF	45..148	CDD:214654	54/106 (51%)
Hsf	NP_001036555.1	Vert_HS_TF	<607..711	CDD:284062
si:dkey-18a10.3	XP_001332195.3	HSF_DNA-bind	7..108	CDD:306863	51/103 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590422
Domainoid	1	1.000	128	1.000	Domainoid score	I5256
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1154048at2759
OrthoFinder	1	1.000	-	-		FOG0000255
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X160
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950