Protein Alignment Hsf and Hsf1

DIOPT Version :9

• Sequence 1: NP_001036555.1
• Gene: Hsf / 37068
• FlyBaseID: FBgn0001222
• Length: 733
• Species: Drosophila melanogaster
• Sequence 2: XP_006241950.1
• Gene: Hsf1 / 79245
• RGDID: 620913
• Length: 553
• Species: Rattus norvegicus
• Alignment Length: 698
• Identity: 214/698 - (30%)
• Similarity: 310/698 - (44%)
• Gaps: 225/698 - (32%)

  Fly    37 GDAAAIGSGVPAFLAKLWRLVDDADTNRLICWTKDGQSFVIQNQAQFAKELLPLNYKHNNMASFI 101
            |..||..|.|||||.|||.||.|.||:.||||:..|.||.:.:|.|||||:||..:||||||||:
  Rat     6 GPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFV 70

  Fly   102 RQLNMYGFHKITSIDNGGL-RFDRDEIEFSHPFFKRNSPFLLDQIKRK---ISNNKNGDDKGVLK 162
            ||||||||.|:..|:.||| :.:||:.||.||.|.|....||:.||||   :|..|:.|.|  ::
  Rat    71 RQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIK--IR 133

  Fly   163 PEAMSKILTDVKVMRGRQDNLDSRFSAMKQENEVLWREIASLRQKHAKQQQIVNKLIQFLITIVQ 227
            .::::::||||::|:|:|:.:||:..|||.|||.||||:||||||||:||::|||||||||::||
  Rat   134 QDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQ 198

  Fly   228 PSRNMSGVKRHVQLMINNTPEIDRARTTSETESESGGGPVIHELREELLDEVMNPSPAGYTAASH 292
            .:| :.||||.:.||:::         :|...|....|      |:..|:.|..|.|  |:|.|
  Rat   199 SNR-ILGVKRKIPLMLSD---------SSSAHSVPKYG------RQYSLEHVHGPGP--YSAPS- 244

  Fly   293 YDQESVSPPAVERPRSNMSISSHNVDYSNQSVEDLLLQGNGTAGGNILVGGAASPMAQSVSQSPA 357
                    ||.    |:.|:      ||:.:|         |:.|.|:     |.:.:....||.
  Rat   245 --------PAY----SSSSL------YSSDAV---------TSSGPII-----SDITELAPTSPL 277

  Fly   358 QHDVYTVTEAPDS-----HVQEVPNSPPYYEEQNVLTTPMVREQEQQKRQQLKENNKLRRQAGDV 417
            .....::.|.|.|     .|:|.|.|||:        :|.|.|
  Rat   278 ASPGRSIDERPLSSSTLVRVKEEPPSPPH--------SPRVLE---------------------- 312

  Fly   418 ILDAGDILVDSSSPKAQRTSIQHSTQPDVMVQPMIIKSEPENSSGLMDLMTPANDLYSVNFISED 482
                       :|| .:..|:.....|...:..::.:|||          |||
  Rat   313 -----------ASP-GRPASMDTPLSPTAFIDSILRESEP----------TPA------------ 343

  Fly   483 MPTDIFEDALLPDGVEEAAKLDQQQKFGQSTVSSGKFASNFDVPTNSTLLDANQASTSKAAAKAQ 547
                                                 ||| ..|.::|       .....|..|.
  Rat   344 -------------------------------------ASN-TAPMDTT-------GAQAPAPPAP 363

  Fly   548 ASEEEGMAVAKYSGAENGNNRDTNNSQLLRMASVLVDQKNTNSSRISHNQAANSYCCSDELHG-- 610
            ::.|:.::||...          |.::..:|:.|                |....|.|..|||
  Rat   364 STPEKCLSVACLD----------NLARAPQMSGV----------------ARLFPCPSSFLHGRV 402

  Fly   611 --------HLESMQDELETLKDLLRGDGVAIDQNMLMGALSRT---PNFQLPEDELLLKLFNDSD 664
                    ||::|...|:.|:.:|...|.::|.:.|:...|.:   |:..||:        .||.
  Rat   403 QPGNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPD--------LDSS 459

  Fly   665 LMDNYGLSFPND---SISSE-KKAPSGSELISY--QPMYDLS-DILDT 705
            |.....|..|.:   .|.:| ..|.||.:|:.|  ||::.|. |.:||
  Rat   460 LASIQELLSPQEPPRPIEAENSNADSGKQLVHYTAQPLFLLDPDAVDT 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsf	NP_001036555.1	HSF	45..148	CDD:214654	61/103 (59%)
		Vert_HS_TF	<607..711	CDD:284062	34/119 (29%)
Hsf1	XP_006241950.1	HSF	14..118	CDD:214654	61/103 (59%)
		Vert_HS_TF	258..553	CDD:284062	79/407 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349198
Domainoid	1	1.000	126	1.000	Domainoid score	I5290
eggNOG	1	0.900	-	-		E1_COG5169
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2901
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1154048at2759
OrthoFinder	1	1.000	-	-		FOG0000255
OrthoInspector	1	1.000	-	-		otm45891
orthoMCL	1	0.900	-	-		OOG6_101482
Panther	1	1.100	-	-	O	PTHR10015
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X160
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760