DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsf and Hsfy2

DIOPT Version :9

Sequence 1:	NP_001036555.1	Gene:	Hsf / 37068	FlyBaseID:	FBgn0001222	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_081937.1	Gene:	Hsfy2 / 71066	MGIID:	1918316	Length:	392	Species:	Mus musculus

Alignment Length:	361	Identity:	76/361 - (21%)
Similarity:	141/361 - (39%)	Gaps:	118/361 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 EEDEEEQLPSRRMHSYGDAAAIGSGVPAFLAKLWRLVDDADTNRLICWTKDGQSFVIQNQAQFAK 85
            |.||:..|.|.                .|..|||::| .:|..:.|.|.:|| ::::.|:..|.|
Mouse    68 EPDEDSNLFSM----------------TFPRKLWKIV-GSDKFKSIWWDEDG-TYIVINEELFKK 114

  Fly    86 ELL----PLN-YKHNNMASFIRQLNMYGFHKITSIDNGGLRFDRD-----------------EIE 128
            |:|    |.. ::.::|.|.:||||:|||.|:..      .|.|.                 :::
Mouse   115 EVLERKAPFRIFETDSMKSLVRQLNLYGFRKMRQ------NFQRSASLPDFLAEEKGISASCKLQ 173

  Fly   129 F-SHPFFKRNSPFLLDQIKRKIS---------------NNKN------------------GDDKG 159
            | .:|.|.|:.|.|::::||:|.               .||:                  ..::.
Mouse   174 FYQNPNFLRDCPHLIERMKRRIGIKTVSRGAAPSLPDFKNKHFRPDLVKMDDHSLGVAVQTSERN 238

  Fly   160 VLKPEAMSKILTDVK--VMRGRQDNLD---SRF-----SAMKQENEVLWREIASLRQKHA---KQ 211
            :|...::|.:....|  :.:|..|.:|   |.|     |:.:...|:|....|.|.:..:   ..
Mouse   239 LLSSSSISNVYLRQKPSLAQGGSDTMDVIRSDFSLATPSSFRPPEEILTHRPAPLNEVSSLCMDS 303

  Fly   212 QQIV----NKLIQFLITIVQPSRNMSGVKRHVQ---LMINNTPEID------RARTTSETESESG 263
            |:|.    :..:.|:||.:..:|   |...|:.   :.:...|...      .:.:::.::|::.
Mouse   304 QRIFTQANDSTVNFIITSITQNR---GDMSHLWNSCIEMQGEPSFQPGFPHFSSSSSTYSDSKAK 365

  Fly   264 GGPVIHELREELLDEVMNPSPAGYTAASHYDQESVS 299
            |.|.:...:|.:         |..|.||..:..|.|
Mouse   366 GEPELPIHKERV---------ASTTLASTSNHHSSS 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsf	NP_001036555.1	HSF	45..148	CDD:214654	35/125 (28%)
Hsf	NP_001036555.1	Vert_HS_TF	<607..711	CDD:284062
Hsfy2	NP_081937.1	HSF_DNA-bind	86..194	CDD:278854	31/115 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845780
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840