Protein Alignment Hsf and hsf1

DIOPT Version :10

• Sequence 1: NP_001036555.1
• Gene: Hsf / 37068
• FlyBaseID: FBgn0001222
• Length: 733
• Species: Drosophila melanogaster
• Sequence 2: XP_009292229.1
• Gene: hsf1 / 58123
• ZFINID: ZDB-GENE-000616-16
• Length: 523
• Species: Danio rerio
• Alignment Length: 702
• Identity: 195/702 - (27%)
• Similarity: 288/702 - (41%)
• Gaps: 244/702 - (34%)

  Fly    34 HSYGDAAAI--GSGVPAFLAKLWRLVDDADTNRLICWTKDGQSFVIQNQAQFAKELLPLNYKHNN 96
            ||.|....:  |:.|||||.|||.||:|.||:.||||:.:|.||.:.:|.:|:||:||..:||||
Zfish     4 HSVGPGGVVVTGNNVPAFLTKLWTLVEDPDTDPLICWSPNGTSFHVFDQGRFSKEVLPKYFKHNN 68

  Fly    97 MASFIRQLNMYGFHKITSIDNGGL-RFDRDEIEFSHPFFKRNSPFLLDQIKRK---ISNNKNGDD 157
            ||||:||||||||.|:..|:.||| :.::|:.||.||:|.|....||:.||||   :||.|:.|.
Zfish    69 MASFVRQLNMYGFRKVVHIEQGGLVKPEKDDTEFQHPYFIRGQEQLLENIKRKVTTVSNIKHEDY 133

  Fly   158 KGVLKPEAMSKILTDVKVMRGRQDNLDSRFSAMKQENEVLWREIASLRQKHAKQQQIVNKLIQFL 222
            |  ...:.:||:::||:.|:|:|:::||:.|.:|.|||:||||:|:|||||::||::||||||||
Zfish   134 K--FSTDDVSKMISDVQHMKGKQESMDSKISTLKHENEMLWREVATLRQKHSQQQKVVNKLIQFL 196

  Fly   223 ITIVQPSRNMSGVKRHVQLMINNT------PEIDRARTTSETESESGGGPVIHELREELLDEVMN 281
            ||:.:.:| :.||||.:.||:|::      |:..|..:   .||.:
Zfish   197 ITLARSNR-VLGVKRKMPLMLNDSSSAHSMPKFSRQYS---LESPA------------------- 238

  Fly   282 PSPAGYTAASHYDQESVSPPAVERPRSNMSISSHNVDYSNQSVEDLLLQGNGTAGGNILVGGAAS 346
            ||...:|....:..||                                        .:..|...|
Zfish   239 PSSTAFTGTGVFSSES----------------------------------------PVKTGPIIS 263

  Fly   347 PMAQSVSQSPAQHDVYTVTE-APDSHVQEVPNSP---PYYEEQNVLTTPMVREQEQQKRQQLKEN 407
            .:.:....||...|.:.... :|..|::|.|:||   |..||    ..|:
Zfish   264 DITELAQSSPVATDEWIEDRTSPLVHIKEEPSSPAHSPEVEE----VCPV--------------- 309

  Fly   408 NKLRRQAGDVILDAG-DILVDSSSPKAQRTSIQHSTQPDVMVQPMIIKSEPENSSGLMDLMTPAN 471
                    :|.:.|| |:.||:            ...|...:..::.:|||.:
Zfish   310 --------EVEVGAGSDLPVDT------------PLSPTTFINSILQESEPVS------------ 342

  Fly   472 DLYSVNFISEDMPTDIFEDALLPDGVEE----AAKLDQQQKFGQ-STVSSGKFASNFDVPTNSTL 531
                               ||.|...|:    .|.||...:..: |.:.||
Zfish   343 -------------------ALTPPPSEQKCLSVACLDNYPQMSEISRLFSG-------------- 374

  Fly   532 LDANQASTSKAAAKAQASEEEGMAVAKYSGAENGNNRDTNNSQLLRMASVLVDQKNTNSSRISHN 596
                 .|||            .:.:..:||.
Zfish   375 -----FSTS------------SLHLRPHSGT---------------------------------- 388

  Fly   597 QAANSYCCSDELHGHLESMQDELETLKDLLRGDGVAIDQNMLMGALSRTPNFQLPEDELLLKLFN 661
                      |||.||||:...||.|:.:|....:..|.:.|....|...:     |..|..|.:
Zfish   389 ----------ELHDHLESIDSGLENLQQILNAQSINFDSSPLFDIFSSAAS-----DVDLDSLAS 438

  Fly   662 DSDLMDNYGLSFPNDSISSEKKAPSGSELISY--QPMYDLSDILDTDDGNND 711
            ..||:.    ..|.....|.....||.:|:.|  ||:. |.|.|.||..:.|
Zfish   439 IQDLLS----PDPVKETESGVDTDSGKQLVQYTSQPIV-LPDPLSTDSSSTD 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsf	NP_001036555.1	HSF	45..148	CDD:214654	58/103 (56%)
		Vert_HS_TF	<579..711	CDD:461944	32/133 (24%)
hsf1	XP_009292229.1	HSF	17..121	CDD:214654	58/103 (56%)
		HSF1	18..248	CDD:227497	116/254 (46%)
		Vert_HS_TF	244..523	CDD:461944	76/437 (17%)