DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsf and HSF2

DIOPT Version :9

Sequence 1:	NP_001036555.1	Gene:	Hsf / 37068	FlyBaseID:	FBgn0001222	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_004497.1	Gene:	HSF2 / 3298	HGNCID:	5225	Length:	536	Species:	Homo sapiens

Alignment Length:	697	Identity:	176/697 - (25%)
Similarity:	298/697 - (42%)	Gaps:	237/697 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 SGVPAFLAKLWRLVDDADTNRLICWTKDGQSFVIQNQAQFAKELLPLNYKHNNMASFIRQLNMYG 108
            |.|||||:|||.||::..||..|.|:::||||::.::.:||||:||..:||||||||:|||||||
Human     5 SNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVLDEQRFAKEILPKYFKHNNMASFVRQLNMYG 69

  Fly   109 FHKITSIDNGGLRFDRD-EIEFSHPFFKRNSPFLLDQIKRKISNNKNGDDKGVLKPEAMSKILTD 172
            |.|:..||:|.::.:|| .:||.||:||:....||:.||||:|::|..::|  ::.|.::||::.
Human    70 FRKVVHIDSGIVKQERDGPVEFQHPYFKQGQDDLLENIKRKVSSSKPEENK--IRQEDLTKIISS 132

  Fly   173 VKVMRGRQDNLDSRFSAMKQENEVLWREIASLRQKHAKQQQIVNKLIQFLITIVQPSRNMSGVKR 237
            .:.::.:|:.::||.|.:|.|||.||:|::.||.|||:|||::.|::||::|:||.::.:| :||
Human   133 AQKVQIKQETIESRLSELKSENESLWKEVSELRAKHAQQQQVIRKIVQFIVTLVQNNQLVS-LKR 196

  Fly   238 HVQLMINNTPEIDRARTTSETESESGGGPVIHELREELLDEVMNPSPAGYTAASHYDQESVSPPA 302

Human   197 ----------------------------------------------------------------- 196

  Fly   303 VERPRSNMSISSHNVDYSNQSVEDLLLQGNGTAGGNILVGGAASPMAQSVSQSPAQHDVYTVTEA 367
             :||                    |||..||....|:.                 ||   .|.|.
Human   197 -KRP--------------------LLLNTNGAQKKNLF-----------------QH---IVKEP 220

  Fly   368 PDSHVQEVPNSPPYYEEQNVLTTPMVREQEQQKRQQLKENNKLRRQAGDVILDAGDILVDSSSPK 432
            .|:|..:||:|               |.:..:.|:::.:         |:|:  .|:..|::.
Human   221 TDNHHHKVPHS---------------RTEGLKPRERISD---------DIII--YDVTDDNAD-- 257

  Fly   433 AQRTSIQHSTQPDVMVQPMIIKSEPENSSGLMDLMTPANDLYSVNFISEDMPTDIFEDALLPDGV 497
            .:...:...|..||:       |:|.|.|...|::                   |.||    |..
Human   258 EENIPVIPETNEDVI-------SDPSNCSQYPDIV-------------------IVED----DNE 292

  Fly   498 EEAAKLDQ---QQKFGQSTVSSGKFASNFDVPTNSTLLDANQASTSKAAAKAQASEEEGMAVAKY 559
            :|.|.:.|   |.:..:.::|||...|:   |..|:.:..
Human   293 DEYAPVIQSGEQNEPARESLSSGSDGSS---PLMSSAVQL------------------------- 329

  Fly   560 SGAENGNNRDTNNSQLLRMASVLVDQKNTNSSRISHNQAANSYCCSDELHGHLESMQDELETLKD 624
                ||::..|:...:..|.|:|.|..|...              ..||..:|:|:...||..:.
Human   330 ----NGSSSLTSEDPVTMMDSILNDNINLLG--------------KVELLDYLDSIDCSLEDFQA 376

  Fly   625 LLRGDGVAIDQNMLMGALSRTPNFQL-PEDELLLKLFNDSDLMDNYGLSFPNDSI-------SSE 681
            :|.|...:||.::|:...  |.:.|: |.|      :.::...:|.||....:::       ..:
Human   377 MLSGRQFSIDPDLLVDLF--TSSVQMNPTD------YINNTKSENKGLETTKNNVVQPVSEEGRK 433

  Fly   682 KKAPSGSELISYQPMYDLSDILDTDDGNNDQEASRRQMQTQSSVLNT 728
            .|:....:||.| ..:.|...||.:..::.::||   ....|.||::
Human   434 SKSKPDKQLIQY-TAFPLLAFLDGNPASSVEQAS---TTASSEVLSS 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsf	NP_001036555.1	HSF	45..148	CDD:214654	56/103 (54%)
Hsf	NP_001036555.1	Vert_HS_TF	<607..711	CDD:284062	25/111 (23%)
HSF2	NP_004497.1	HSF	6..110	CDD:214654	56/103 (54%)
		Nuclear localization signal. /evidence=ECO:0000255	108..122		6/15 (40%)
		Hydrophobic repeat HR-A/B	119..192		29/74 (39%)
		Nuclear localization signal. /evidence=ECO:0000255	195..210		9/100 (9%)
		Vert_HS_TF	230..512	CDD:368967	67/363 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..337		10/68 (15%)
		Hydrophobic repeat HR-C	360..385		7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..438		4/30 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155310
Domainoid	1	1.000	126	1.000	Domainoid score	I5413
eggNOG	1	0.900	-	-		E1_COG5169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1154048at2759
OrthoFinder	1	1.000	-	-		FOG0000255
OrthoInspector	1	1.000	-	-		otm41758
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10015
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2153
SonicParanoid	1	1.000	-	-		X160
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.840