Protein Alignment Hsf and Hsf5

DIOPT Version :10

• Sequence 1: NP_001036555.1
• Gene: Hsf / 37068
• FlyBaseID: FBgn0001222
• Length: 733
• Species: Drosophila melanogaster
• Sequence 2: NP_001038992.1
• Gene: Hsf5 / 327992
• MGIID: 2685585
• Length: 624
• Species: Mus musculus
• Alignment Length: 681
• Identity: 144/681 - (21%)
• Similarity: 218/681 - (32%)
• Gaps: 211/681 - (30%)

  Fly    49 FLAKLWRLVDDADTNRLICWTKDGQSFVIQNQAQFAKELL------------------------- 88
            |.||||||| ::...|.|.|...|:..:| :|..|..|||
Mouse    15 FPAKLWRLV-NSPRYRSIRWDGRGEGLLI-DQPLFEAELLSPPGPGAGGAGGAGSSGGGGGSGVG 77

  Fly    89 -----PLNYKHNNMASFIRQLNMYGFHKIT-----------SIDNGGLRFDRDEIEFSHPFFKRN 137
                 |..:|..|..|||||||:|||.|:.           ....||...|.....|..|.|:|:
Mouse    78 AAGAEPELFKTTNFTSFIRQLNLYGFRKVVLGGPGAAGPGPGPGAGGPAGDGPLHHFHSPHFRRD 142

  Fly   138 SPFLLDQIKRKISNNKNGDDKGVLKPEAMSKILTDVKVMRGRQDNLDSRFSAMKQENEVLWREIA 202
            .|.||..:||..|.||                   .|:..|.               ||..|.
Mouse   143 QPQLLVHLKRLTSANK-------------------AKLAAGL---------------EVPCRP-- 171

  Fly   203 SLRQKHAKQQQIVNKLIQFLITIVQPSRNMSGVKRHVQLMINNTPEIDRARTTSETESESGGGPV 267
                        .|:..:.|||....|.:.|     ...:.:..|....|....|.......|..
Mouse   172 ------------PNRFQRLLITSASASASAS-----TSPLQHQDPPPQPAGPRPEQHGPVAVGQF 219

  Fly   268 IHELREELLDEVMNPSPAGYTAASHYDQESVSPPAVER----PRS-NMSISSH------NVDYSN 321
            ....|.:      |.||..|.:.|.::..:.....::|    ||: ..|:..|      :..:|:
Mouse   220 HRSFRRD------NLSPYSYVSTSSHNHSAFPLKGLDRTPIPPRTWQNSLGMHPGQVETSPTFSD 278

  Fly   322 QSVEDLLLQGNGTAGGNILVGGAASPMAQSVSQ----SPAQHDVYTVTE---------------A 367
            :.|...:||...|.....|...|.|...|...|    |..::..||.:.               :
Mouse   279 KGVPFPVLQRFPTEVTYTLQPSATSVHVQQGPQTMVSSSQKYSNYTPSAQYSQAYYPTAVLQCCS 343

  Fly   368 PDSHVQEV-----PNSPPYYEEQNVLTTPMVREQEQQKRQQLKEN--------NKLRRQAGDVIL 419
            |.:|:..:     |.:..|.........||   |.....:.|..|        ||    ..:|.|
Mouse   344 PPTHMDALSSCVTPTASSYAHCNYFQNPPM---QSSYPVEFLPSNWPCSATDENK----KTEVNL 401

  Fly   420 DAGDILVDS--SSPKAQRTSIQ------HSTQPD--VMVQPMIIKSEPENSSGLMDL--MTP-AN 471
            :|...:||.  ||||.:...::      .|:|.:  ..:.|....|.|.::|....|  :|| .:
Mouse   402 EAVFQIVDELHSSPKLEMVKVEPVETQCPSSQANRGQHILPNANSSNPSSTSQASQLEPLTPVGS 466

  Fly   472 DLYSVNFISEDMPTDIFEDALLPDGVEEAAKLDQQQKFGQSTV---------------------- 514
            |:.|....:|...|     ..||...|....:...|....||:
Mouse   467 DITSFVVGTEQAIT-----CSLPQSPEYIYTIHTAQPLENSTMQESATIQQTHVKLKEQLNHNPS 526

  Fly   515 -SSGKFASNFDVPTNSTLLDANQASTSKAAAKAQASEEEGMAVAKYSGAENGNNRDTNNSQLLRM 578
             ||..|... .:|.::..:|::....:..:.....||:.|..::: .|..|.:.:||..|...|.
Mouse   527 PSSVVFVQE-GLPFSTPQVDSSIKCQTNPSENILPSEQMGFLISE-MGPANKSTKDTGLSTPARY 589

  Fly   579 ASVLVDQKNTNSSRISHNQAANSYCCSDELH 609
                            ..:.:||...|.:||
Mouse   590 ----------------RERRSNSQGKSPDLH 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsf	NP_001036555.1	HSF	45..148	CDD:214654	43/139 (31%)
		Vert_HS_TF	<579..711	CDD:461944	5/31 (16%)
Hsf5	NP_001038992.1	HSF_DNA-bind	15..152	CDD:459813	42/138 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	52..77		1/24 (4%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..138		4/25 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	186..214		5/32 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	429..461		7/31 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	572..605		11/49 (22%)