DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsf and Hsf4

DIOPT Version :9

Sequence 1:	NP_001036555.1	Gene:	Hsf / 37068	FlyBaseID:	FBgn0001222	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_001099647.1	Gene:	Hsf4 / 291960	RGDID:	1310808	Length:	399	Species:	Rattus norvegicus

Alignment Length:	448	Identity:	105/448 - (23%)
Similarity:	190/448 - (42%)	Gaps:	93/448 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 GFHKITSIDNGG-LRFDRDEIEFSHPFFKRNSPFLLDQIKRKISNNKNGDDKGVLKPEAMSKILT 171
            ||.|:.||:.|| ||.:||.:||.||.|.|....||::::||:...:..|.:  .:||.:.::|.
  Rat    19 GFRKVVSIEQGGLLRPERDHVEFQHPSFVRGCEQLLERVRRKVPALRGDDTR--WRPEDLGRLLG 81

  Fly   172 DVKVMRGRQDNLDSRFSAMKQENEVLWREIASLRQKHAKQQQIVNKLIQFLITIVQPSRNMSGVK 236
            :|:.:||.|::.::|...::|:||:||||:.:|||.|::|.:::.||||.|...:|...:.:|.|
  Rat    82 EVQALRGVQESTEARLQELRQQNEILWREVVTLRQSHSQQHRVIGKLIQCLFGPLQTGPSSTGAK 146

  Fly   237 RHVQLMINNTPEIDRARTTSETESESGGGPVIHELREELLDEVMNPSPAGYTAASHYDQESVSPP 301
            |.:.||::.       .:.....::....||...|   |.|.....||:..:       .|..||
  Rat   147 RKLSLMLDE-------GSACSASAKFNACPVSGAL---LQDPYFIQSPSTCS-------PSQRPP 194

  Fly   302 ---AVERPRSNMSISSHNVDYSNQSVEDLLLQGNGTAGGNILVGGAASPMAQSVSQSPAQHDVYT 363
               |:..|....|::|....:        ||:..|....  ::.||..|:..:|.|:
  Rat   195 WASALTGPEGLSSLTSQKTAH--------LLKDTGFLPP--VLAGAPPPLPVAVVQA-------- 241

  Fly   364 VTEAPDSHVQEVPNSPPYYEEQNVLTTPMVREQEQQKRQQLKENNKLRRQAGDVILDAGDILVDS 428
            :.|...|...|.|.|              :::.|.:..:::.:.       |.:.||.|
  Rat   242 ILEGKGSFSPEGPRS--------------IQQPEPRGPREVPDR-------GTLGLDRG------ 279

  Fly   429 SSPKAQRTSIQHSTQPDVMVQPMIIKSEPENSSGLMDLMTPANDLYSVNFISEDMPTDIFEDALL 493
                        :..|:.::.|::::..||.... ||.:.|:........:..||...:.: .|.
  Rat   280 ------------NRSPESLLPPVLLRPPPETVEP-MDALGPSLHGREWTLMDLDMELSLMQ-PLA 330

  Fly   494 PDGVEEAAKLDQQQKFG-----------QSTVSSGKFASNFDVPTNSTLLDANQASTS 540
            |:..|....:......|           ...|.:....:...||...||.:|.:::.|
  Rat   331 PERAEAELTVKDLTSSGVGKDHTLGTPLMLDVQADLEGAALSVPGALTLYNATESNAS 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsf	NP_001036555.1	HSF	45..148	CDD:214654	19/40 (48%)
Hsf	NP_001036555.1	Vert_HS_TF	<607..711	CDD:284062
Hsf4	NP_001099647.1	HSF_DNA-bind	<18..60	CDD:299902	19/40 (48%)
Hsf4	NP_001099647.1	PRK13923	<74..119	CDD:276343	17/44 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349200
Domainoid	1	1.000	126	1.000	Domainoid score	I5290
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1154048at2759
OrthoFinder	1	1.000	-	-		FOG0000255
OrthoInspector	1	1.000	-	-		otm45891
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10015
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X160
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.950