DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsf and prr1

DIOPT Version :9

Sequence 1:	NP_001036555.1	Gene:	Hsf / 37068	FlyBaseID:	FBgn0001222	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_594284.1	Gene:	prr1 / 2541756	PomBaseID:	SPAC8C9.14	Length:	539	Species:	Schizosaccharomyces pombe

Alignment Length:	592	Identity:	121/592 - (20%)
Similarity:	206/592 - (34%)	Gaps:	201/592 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 SGVPAFLAKLWRLVDDADTNRLICWTKDGQSFVIQNQAQFAKELLPLNYKHNNMASFIRQLNMYG 108
            :|...|:.||:.::::.:...::.|:..|.||::.:..:|.|.:||.::||:|.|||:||||.|.
pombe     5 NGSSDFVRKLFNMLEEPEYRHILRWSDSGDSFIVLDTNEFTKTILPRHFKHSNFASFVRQLNKYD 69

  Fly   109 FHKITSIDNGGLRFDRDEIEFSHPFFKRNSPFLLDQIKRKISNNKNGDDKGV------LKPEA-- 165
            |||:...:.....:.....||.|..|:.:...|||.||||..:.:|..::..      ||.:.
pombe    70 FHKVRHEEGAPSIYGEGAWEFRHDDFQLHHKDLLDNIKRKAPSKRNLANENTAPVIENLKQQVDS 134

  Fly   166 ---------------------------------------MSKI---LTDVKVMRGRQDNLDSRFS 188
                                                   ||.|   |.|::....||.|..:.|.
pombe   135 ILDFQKLLDRNLSGLATSYQTILLKMFELKRGIESRDLLMSSIISYLCDLEGSTQRQANPGAMFV 199

  Fly   189 AMKQENEVL--WREIASLRQKHAKQQQIVNKLIQFLITIVQPSR-----NMSGVKRHVQLMINNT 246
            ......|:|  ::.:|..:......|||.|::.|........|:     |:.    ..|..:.||
pombe   200 PSHPLQELLNAYQALAKGQVATTSPQQIPNQIQQASAATTASSKMTVDTNLG----TAQPSLYNT 260

  Fly   247 PEIDRARTTSETESES-----------------------GGGPVIHELREELLDEVMNPSPAGYT 288
            |..|......|..::|                       |..|:.     |....:.:|:|..:|
pombe   261 PSSDYELANQEKPADSMASAASLNTPLSSNDHSLNPHAHGSYPMY-----EKFQPIQHPNPGSFT 320

  Fly   289 AASHYDQESVSPPAVERPRSNMSISSHNVDYSNQSVEDLLLQGNGTAGGNILVGGAASPMAQSVS 353
              :|.|             ||.|::......||.|:                  ..||.:|.|:|
pombe   321 --THLD-------------SNASMAKSFSQISNDSL------------------AKASSVATSMS 352

  Fly   354 QSPAQHDVYTVTEAPDSHVQEVPNSPPYYEEQNVLTTPMVREQEQQKRQQLKENNKLRRQAGDVI 418
            |..|                .||.:..:..:..:|   :|.:.|..:|..:|.......|. ||.
pombe   353 QMGA----------------AVPTTGLWKRQPRIL---LVEDDELSRRMTIKFLTSFDCQV-DVA 397

  Fly   419 LD---------AGD---ILVDSSSPKAQRTSI-------QHSTQ--------------------- 443
            :|         ||.   ||:|...|.....|:       .|:|.
pombe   398 VDGIGAVNKANAGGFDLILMDFILPNLDGLSVTCLIRQYDHNTPILAITSNISMNDAVTYFNHGV 462

  Fly   444 PDVMVQP-------MIIKS------EPENSSGLMDLMT---PANDLYSVNF-ISEDMPTDIFEDA 491
            .|::|:|       .::|.      :.:||..:.|:.:   ..:|...|.| :..|.|  ::...
pombe   463 TDLLVKPFTKLTLLQLLKKQLLNLLQADNSINMSDVPSTKEAKDDKAPVTFYLENDAP--MYPQQ 525

  Fly   492 LLPDGVE 498
            :|.|.::
pombe   526 MLQDPIQ 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsf	NP_001036555.1	HSF	45..148	CDD:214654	35/102 (34%)
Hsf	NP_001036555.1	Vert_HS_TF	<607..711	CDD:284062
prr1	NP_594284.1	HSF1	1..286	CDD:227497	66/284 (23%)
		HSF	6..109	CDD:214654	35/102 (34%)
		OmpR	368..>470	CDD:223816	20/105 (19%)
		REC	371..470	CDD:238088	20/102 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X160
TreeFam	1	0.960	-	-
	5	4.870