Protein Alignment Hsf and HSFY2

DIOPT Version :9

• Sequence 1: NP_001036555.1
• Gene: Hsf / 37068
• FlyBaseID: FBgn0001222
• Length: 733
• Species: Drosophila melanogaster
• Sequence 2: NP_714927.1
• Gene: HSFY2 / 159119
• HGNCID: 23950
• Length: 401
• Species: Homo sapiens
• Alignment Length: 354
• Identity: 93/354 - (26%)
• Similarity: 143/354 - (40%)
• Gaps: 77/354 - (21%)

  Fly    49 FLAKLWRLVDDADTNRLICWTKDGQSFVIQNQAQFAKELLPLN-----YKHNNMASFIRQLNMYG 108
            |..|||::| ::|..:.|.|.::|...|| |:..|.||:|...     ::.:.:.||:||||:||
Human    80 FPRKLWKIV-ESDQFKSISWDENGTCIVI-NEELFKKEILETKAPYRIFQTDAIKSFVRQLNLYG 142

  Fly   109 FHKITSIDNGGLRFDR---------DEIEFS---------HPFFKRNSPFLLDQIKRKISNNKNG 155
            |.||..      .|.|         :|.|.|         :|.|||..|.||.::||:| ..||.
Human   143 FSKIQQ------NFQRSAFLATFLSEEKESSVLSKLKFYYNPNFKRGYPQLLVRVKRRI-GVKNA 200

  Fly   156 DDKGVLKPEAMSKILTDVKVMR------------GRQDNLDSRFSAMKQENEVLWREIASLRQKH 208
            .....|..|..:|     |..|            ..:.:.:|.|||.|..|..|.|| :|:|
Human   201 SPISTLFNEDFNK-----KHFRAGANMENHNSALAAEASEESLFSASKNLNMPLTRE-SSVR--- 256

  Fly   209 AKQQQIVNKLIQFLITIVQPSRNMSGVKRHVQLMINNTPEIDRARTTSETESES----GGGPVIH 269
               |.|.|..:........||.:.| |....|:..:....:::. ||....|.|    ..|.:::
Human   257 ---QIIANSSVPIRSGFPPPSPSTS-VGPSEQIATDQHAILNQL-TTIHMHSHSTYMQARGHIVN 316

  Fly   270 ELREELLD-EVMNPSPAGYTAASHYDQESVSPPAVERPRSNMSISSHNVDYSNQSVEDLLLQGNG 333
            .:...... .:::|...||...      :|.|.||  |.....:|.:...|.|     :|..||.
Human   317 FITTTTSQYHIISPLQNGYFGL------TVEPSAV--PTRYPLVSVNEAPYRN-----MLPAGNP 368

  Fly   334 TAGGNILVGGAASPMAQSVSQSPAQHDVY 362
            ......:...:|:|.::...| |:..|.|
Human   369 WLQMPTIADRSAAPHSRLALQ-PSPLDKY 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsf	NP_001036555.1	HSF	45..148	CDD:214654	40/121 (33%)
		Vert_HS_TF	<607..711	CDD:284062
HSFY2	NP_714927.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30
		HFS-type DNA-binding domain	79..213		46/141 (33%)
		HSF_DNA-bind	80..194	CDD:306863	40/121 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155315
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940