DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsf and hsf2

DIOPT Version :9

Sequence 1:	NP_001036555.1	Gene:	Hsf / 37068	FlyBaseID:	FBgn0001222	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_571942.1	Gene:	hsf2 / 140427	ZFINID:	ZDB-GENE-011128-1	Length:	489	Species:	Danio rerio

Alignment Length:	498	Identity:	153/498 - (30%)
Similarity:	244/498 - (48%)	Gaps:	101/498 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 SGVPAFLAKLWRLVDDADTNRLICWTKDGQSFVIQNQAQFAKELLPLNYKHNNMASFIRQLNMYG 108
            |.|||||.|||.||:|:|||..|||:::|.||::.::.:||||:||..:||||||||:|||||||
Zfish     5 SNVPAFLTKLWTLVEDSDTNEFICWSQEGNSFLVLDEQRFAKEILPKFFKHNNMASFVRQLNMYG 69

  Fly   109 FHKITSIDNGGLRFDRD-EIEFSHPFFKRNSPFLLDQIKRKISNNKNGDDKGVLKPEAMSKILTD 172
            |.|:..||:|.::.:|| .:||.||:||.....||:.||||:||.:..:.|  ::.:.:|||||.
Zfish    70 FRKVMHIDSGIVKQERDGPVEFQHPYFKHGQDDLLENIKRKVSNARPEESK--IRQDDLSKILTS 132

  Fly   173 VKVMRGRQDNLDSRFSAMKQENEVLWREIASLRQKHAKQQQIVNKLIQFLITIVQPSR--NMSGV 235
            |:.:..:|:|:|:|.:.:|:|||.||.|::.||:.|.:|||::.:|:||:.|:||.:|  |:..
Zfish   133 VQSVHEQQENMDARLATLKRENEALWTELSDLRKVHVQQQQVIKELVQFIFTLVQNNRLLNLKR- 196

  Fly   236 KRHVQLMINNTPE----------IDRARTT---SETESESGGGPVIHELREELLDEVMNPSPA-G 286
            ||.:.|.||....          ||.::||   .:..|:.....:|.::.:|      :|... |
Zfish   197 KRPLALNINGKKSKFIHQLFEEPIDHSKTTVNGLKNNSDISDDVIICDITDE------DPEVTDG 255

  Fly   287 YTAASHYDQESV------SPPAVERPRSNMSI------------SSHNVDYSNQSVE-------- 325
            .:.....|.|.|      ||..|::..:|.:|            ::|:|..:|.:::
Zfish   256 ISVPDEEDAEIVEITYESSPKTVQQDSANGTIVNSTAHQEAEPKTTHDVSTTNSALQLNKPSCLS 320

  Fly   326 --------DLLLQGNGTAGGNILVGGAASPMAQSVSQSPAQHDVYTVTEAPDSHVQEVPNSPPYY 382
                    |.:|..||....||.:.|....|....|...:..|...:......::     .|...
Zfish   321 LEDPMKLMDSILSENGAISQNINLLGKVELMDYLDSIDCSLEDFQAMLYGKQFNI-----DPDII 380

  Fly   383 EEQNVLTTPMVREQEQQKRQQLKENNKLRRQAGDVILDAGDILVDSSSPKAQRTSIQHSTQP--- 444
            ||       .:.|.:....:..|||           ||         |....:..||::|.|
Zfish   381 EE-------TISETKNNNSKANKEN-----------LD---------SENTDKQLIQYTTCPLMA 418

  Fly   445 --DVMVQPMIIKSEPENSSGLMD----LMTPANDLYSVNFISE 481
              |..........:||:...|:|    :.||.:.|..:..::|
Zfish   419 FLDGCTPLTPSDPQPEDPPDLLDESLEMKTPRSSLIRLEPLTE 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsf	NP_001036555.1	HSF	45..148	CDD:214654	58/103 (56%)
Hsf	NP_001036555.1	Vert_HS_TF	<607..711	CDD:284062
hsf2	NP_571942.1	HSF	6..110	CDD:214654	58/103 (56%)
hsf2	NP_571942.1	Vert_HS_TF	222..464	CDD:284062	51/278 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590420
Domainoid	1	1.000	128	1.000	Domainoid score	I5256
eggNOG	1	0.900	-	-		E1_COG5169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1154048at2759
OrthoFinder	1	1.000	-	-		FOG0000255
OrthoInspector	1	1.000	-	-		otm24944
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10015
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2153
SonicParanoid	1	1.000	-	-		X160
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.840