Protein Alignment Hsf and HSF5

DIOPT Version :10

• Sequence 1: NP_001036555.1
• Gene: Hsf / 37068
• FlyBaseID: FBgn0001222
• Length: 733
• Species: Drosophila melanogaster
• Sequence 2: XP_011522585.1
• Gene: HSF5 / 124535
• HGNCID: 26862
• Length: 603
• Species: Homo sapiens
• Alignment Length: 666
• Identity: 140/666 - (21%)
• Similarity: 224/666 - (33%)
• Gaps: 222/666 - (33%)

  Fly    49 FLAKLWRLVDDADTNRLICWTKDGQSFVIQNQAQFAKELL-----------------PLNYKHNN 96
            |.||||||| ::...|.|.|...|:..:| :|..|..|||                 |..:|..:
Human    14 FPAKLWRLV-NSPRYRSIRWDGRGEGLLI-DQPLFEAELLSPPGPGGGGGTAGAGAEPELFKTTS 76

  Fly    97 MASFIRQLNMYGFHKIT--------SIDNGGLRFDRDEIEFSHPFFKRNSPFLLDQIKRKISNNK 153
            ..|||||||:|||.|:.        ...||.|.      .|.:|.|:|:.|.||..:||..|.||
Human    77 FTSFIRQLNLYGFRKVVLGGPGGGKPAGNGPLH------HFHNPHFRRDQPQLLVHLKRLTSANK 135

  Fly   154 ----NGDDKGVLKPEAMSKIL-TDVKVMRG------------------------------RQDNL 183
                .|.:.....|....::| |.......                              |:|:|
Human   136 AKLAAGLEVPCRPPNRFQRLLITSASAATAPLQHQQPPPPAGPRPEPHGPVAVGQFHRSFRRDSL 200

  Fly   184 DSRFSAMKQENEVLWREIASLRQKHAKQQQIVNKLIQFLITIVQPSRNMSGVKRHVQLMINNTPE 248
             |.:|.:...:    .:.::...|...:..:.:::.|          |..|:         :..:
Human   201 -SPYSCVSTPS----HDHSTYPLKGLDRTPVPHRIWQ----------NSLGM---------HPGQ 241

  Fly   249 IDRARTTSETESESG-GGPVIHELREELLDEVMNPSPAGYTAASHYDQESVSPPAVERPRSNMSI 312
            ::    ||.|.|:.| ..||:.....| :...:.||    |.:.|..|...:..:..:..||.:.
Human   242 VE----TSPTFSDKGVPFPVLQRFPTE-VTYTLQPS----TTSVHVQQGPQTMVSSSQKYSNYTP 297

  Fly   313 SSHNVDYSNQSVEDLLLQGNGTAGGNILVGGAASPMAQS------------VSQSPAQHDVYTVT 365
            |:   .||.......:||.......:.| ....:|.|.|            .||:|:....|.|.
Human   298 SA---QYSQAYYPTAVLQCCSPTHMDAL-SSCVTPTASSYAHCNYFQLYFFFSQNPSMQSSYPVE 358

  Fly   366 EAPDSHVQEVPNSPPYYEEQNVLTTPMVREQEQQKRQQLKENNKLRRQAGDVILDAGDILVDS-- 428
            ..|.       |.|....::|..|                          :|.|:|...:||.
Human   359 FLPS-------NWPCSTTDENTKT--------------------------EVNLEAVFQIVDELH 390

  Fly   429 SSPKAQRTSI-----QHSTQPDVMVQPMIIKSEPEN-----SSGLMDLMTP-ANDLYSVNFISED 482
            ||||.:...:     |..|.|....|.::..|...|     .:..::.:|| .:|:.|  |:
Human   391 SSPKLEMVKVEPVENQCPTSPSYRGQHILANSNNSNPCSASQASQLEPLTPVGSDIMS--FV--- 450

  Fly   483 MPTDIFEDALLPDGVEEAAKLDQQQKFGQSTVSSGKFASNFDV---------------------- 525
            :.|:......||...|....:...|....||:..........|
Human   451 VGTEQAVACSLPQSPEYIYTIHTAQPVENSTIQESAAIQQAHVKLKEHLNHNPSPSSVVFVQEGP 515

  Fly   526 PTNSTLLDAN---QAST--------------SKAAAKAQASEEEGMAV-AKY----SGAENGNNR 568
            |.::..:|||   |.|:              |:....::.||:.|:|. |:|    |.::.|.:.
Human   516 PFSTHQVDANIKCQTSSRENILPSEQMGFLISEMGPASKPSEDTGLATPARYREHRSNSQQGKSP 580

  Fly   569 DTNNSQLLRMASVLVD 584
            |.:         :|||
Human   581 DLH---------LLVD 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsf	NP_001036555.1	HSF	45..148	CDD:214654	42/123 (34%)
		Vert_HS_TF	<579..711	CDD:461944	3/6 (50%)
HSF5	XP_011522585.1	HSF_DNA-bind	14..129	CDD:459813	41/122 (34%)