DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsf and HSFX1

DIOPT Version :9

Sequence 1:	NP_001036555.1	Gene:	Hsf / 37068	FlyBaseID:	FBgn0001222	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_057237.1	Gene:	HSFX1 / 100506164	HGNCID:	29603	Length:	423	Species:	Homo sapiens

Alignment Length:	403	Identity:	102/403 - (25%)
Similarity:	149/403 - (36%)	Gaps:	95/403 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 EQLPSRRMHSYGDAAAIGS----GVPAFLAKLWRLVDDADTNRL--ICWTKDGQSFVIQNQAQFA 84
            |:...||.|..||....|.    .:| |..||||||   .:|:.  |.|...|...|| ||..|.
Human    73 EEASFRRPHPDGDVPPQGEDNLLSLP-FPQKLWRLV---SSNQFSSIWWDDSGACRVI-NQKLFE 132

  Fly    85 KELLPLNYKH-----NNMASFIRQLNMYGFHK-----------------ITSIDNGGLRFDRDEI 127
            ||:|..:..|     .::.||.||||:|||.|                 :.||.|        ::
Human   133 KEILKRDVAHKVFATTSIKSFFRQLNLYGFRKRRQCTFRTFTRIFSAKRLVSILN--------KL 189

  Fly   128 EF-SHPFFKRNSPFLLDQIKRKISNNKNGDDKGVLKPEAMSKILTDVKVMRGRQDNLDSRFSAMK 191
            || .||:|:|:||.||.::||::........:...||||....|.....  .:||:      ...
Human   190 EFYCHPYFQRDSPHLLVRMKRRVGVKSAPRHQEEDKPEAAGSCLAPADT--EQQDH------TSP 246

  Fly   192 QENEVLWREIASLRQKHAKQQQIVNKLIQFLITIVQPSRNMSGVKRHVQLMINNTPEIDRARTTS 256
            .||:   :.....|:......||.:........::.|...::.         :|:|....|...|
Human   247 NEND---QVTPQHREPAGPNTQIRSGSAPPATPVMVPDSAVAS---------DNSPVTQPAGEWS 299

  Fly   257 ETESESGGGPVIHELREELLDEVMNPSPAG----YTAASHYDQESVSPPAVERPRSNMSISSHNV 317
            | .|::...||           ...|.||.    |...|.....|.. |.|..|.::.|..:  :
Human   300 E-GSQAHVTPV-----------AAVPGPAALPFLYVPGSPTQMNSYG-PVVALPTASRSTLA--M 349

  Fly   318 DYSNQSVEDLLLQGNGTAGGNILVGGAASPMAQSV--SQSPAQHDVYTVTEAPDSH-------VQ 373
            |.:......:|...:......::..|||.|.|..|  ...||.|.     ..|.||       ..
Human   350 DTTGLPAPGMLPFCHLWVPVTLVAAGAAQPAASMVMFPHLPALHH-----HCPHSHRTSQYMPAS 409

  Fly   374 EVPNSPPYYEEQN 386
            :.|.:.|.|.:|:
Human   410 DGPQAYPDYADQS 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsf	NP_001036555.1	HSF	45..148	CDD:214654	45/127 (35%)
Hsf	NP_001036555.1	Vert_HS_TF	<607..711	CDD:284062
HSFX1	NP_057237.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56
		HSF_DNA-bind	105..211	CDD:278854	40/117 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..303		18/108 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..423		7/26 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155311
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840