DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsf and hsf2

DIOPT Version :9

Sequence 1:	NP_001036555.1	Gene:	Hsf / 37068	FlyBaseID:	FBgn0001222	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	XP_002937263.1	Gene:	hsf2 / 100125207	XenbaseID:	XB-GENE-954977	Length:	530	Species:	Xenopus tropicalis

Alignment Length:	538	Identity:	160/538 - (29%)
Similarity:	249/538 - (46%)	Gaps:	116/538 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 CW-----------TKDGQSFVIQNQAQFAKELLPLNYKHNNMASFIRQLNMYGFHKITSIDNGGL 120
            ||           |.:||||::.::.:||||:||..:||||||||:||||||||.|:..:|:|.:
Frog    33 CWQSQRQSGMSDPTLNGQSFLVLDEQRFAKEILPKYFKHNNMASFVRQLNMYGFRKVVHVDSGIV 97

  Fly   121 RFDRD-EIEFSHPFFKRNSPFLLDQIKRKISNNKNGDDKGVLKPEAMSKILTDVKVMRGRQDNLD 184
            :.:|| .:||.||||.:....||:.||||:|:.:  .::|.::.|.:||||::...::.:|:.:|
Frog    98 KQERDGPVEFQHPFFVQGQDELLENIKRKVSSTR--PEEGKVRQEDISKILSNAAKVQVQQETID 160

  Fly   185 SRFSAMKQENEVLWREIASLRQKHAKQQQIVNKLIQFLITIVQPSRNMSGVKRHVQLMI--NNTP 247
            ||...:|::||.|||||:.||.|||:|||::.|::||::|:||.:|.:| :||...|::  ||:|
Frog   161 SRLFTLKRDNEALWREISDLRNKHAQQQQVIRKIVQFIVTLVQNNRLVS-LKRKQPLLLNTNNSP 224

  Fly   248 EIDRART-TSETESESGGGP---------------VIHELREELLDEVMNPSPAGYTAASHYDQE 296
            :..|.:| ..||..::...|               ||:::.:.:..|..........|......|
Frog   225 KSTRLQTIVKETVEDNHHVPLRTEGLKRGDLSEDIVIYDITDNVEFEEEEKKETATHAVPESSDE 289

  Fly   297 SVSPPAVERPRSNMSISSHNVDYSNQSVEDLLLQGNGTAGGNILVGGAASPMAQSVSQSPAQHDV 361
            |.|....||....:.|...:.||.:..|.    |||..              |::..:|||..:
Frog   290 STSDTVTERLSPEIVIVEDDSDYEDTPVG----QGNKN--------------AETGLRSPAGEN- 335

  Fly   362 YTVTEAP-DSHVQEVPNSPPYYEEQNVLTTPMVREQEQQKRQQLKENNKLRRQAGDVILDAGDIL 425
               |..| .|...::.|...:.:|..|.....:..:.....|.|....|:....   .||:.|..
Frog   336 ---TSVPLMSSALQLNNQSSFNQEDPVTMMDSILNESGVISQNLNLLGKVELMD---YLDSIDCT 394

  Fly   426 VDSSSPKAQRTSIQHSTQPDVMVQPMI-----IKSE-----PENSSG--------LMDLMT-PAN 471
            :|..  ||..:..|.|...|::|....     :||.     ||:|:|        |:...| |..
Frog   395 LDDF--KALLSGRQFSIDRDLLVDLETKGIESLKSSGAVPGPEDSNGDNHKSDQQLVQYTTFPLL 457

  Fly   472 DLY---SVNFISEDMPTDIFEDALLPDGVEEAAKLDQQQKFGQSTVSSGKFASNFDV-PTNSTLL 532
            .|:   |.|..::..|....||.||                          .||||. |..|.|:
Frog   458 ALFDGDSGNVTTDTPPDKTLEDQLL--------------------------ESNFDSRPPQSKLM 496

  Fly   533 DANQASTSKAAAKAQASE 550
            .....|      :|:|||
Frog   497 RLEPLS------EAEASE 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsf	NP_001036555.1	HSF	45..148	CDD:214654	44/92 (48%)
Hsf	NP_001036555.1	Vert_HS_TF	<607..711	CDD:284062
hsf2	XP_002937263.1	HSF	<48..126	CDD:214654	41/77 (53%)
hsf2	XP_002937263.1	Vert_HS_TF	246..507	CDD:368967	65/319 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I5223
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1154048at2759
OrthoFinder	1	1.000	-	-		FOG0000255
OrthoInspector	1	1.000	-	-		otm48979
Panther	1	1.100	-	-	LDO	PTHR10015
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2153
SonicParanoid	1	1.000	-	-		X160
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.050