DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsf and hsf2.2

DIOPT Version :9

Sequence 1:	NP_001036555.1	Gene:	Hsf / 37068	FlyBaseID:	FBgn0001222	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_001090859.1	Gene:	hsf2.2 / 100038273	XenbaseID:	XB-GENE-5919609	Length:	467	Species:	Xenopus tropicalis

Alignment Length:	481	Identity:	124/481 - (25%)
Similarity:	204/481 - (42%)	Gaps:	94/481 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 SGVPAFLAKLWRLVDDADTNRLICWTKDGQSFVIQNQAQFAKELLPLNYKHNNMASFIRQLNMYG 108
            |.||.||.|:|.||:|......|.|::||.||::.::..|||::||.::||:|||||:||||.||
Frog     5 SSVPKFLTKIWALVEDPINKDYITWSQDGNSFIVVDEECFAKDILPKHFKHSNMASFVRQLNWYG 69

  Fly   109 FHKITSIDNGGLRFDR-DEIEFSHPFFKRNSPFLLDQIKRKISNNKNGDDKGVLKPEAMSKILTD 172
            |||:.:.:.|.::.:: ....:.|.||||....||.:||||:...:..:.|.|  |:...|||..
Frog    70 FHKVVNDEPGVVKQEKYCSGRYQHAFFKRGHEDLLTKIKRKVPVPRIDEGKNV--PDDNHKILAF 132

  Fly   173 VKVMRGRQDNLDSRFSAMKQENEVLWREIASLRQKHAKQQQIVNKLIQFLITIVQPSRNMSGVKR 237
            :..::||||.::|...::|:||:.||:|:..||||..:.......        |.||::...:..
Frog   133 LHQLQGRQDVIESTVESLKRENKSLWKEVLELRQKQFQNPPDYES--------VAPSQSYDRMSA 189

  Fly   238 HVQLMINNTPEIDR----------ARTTSETESESGGGPV------IHELREELLDEVMNPSPAG 286
            |..|||:||...::          .:....|.|.|..|.|      .:.:||:.|:.....|..
Frog   190 HEPLMIDNTGNYNQLSVPKSPQNTEQVFDNTASWSVNGDVTRGTKRTYSMREDPLESSAEESSG- 253

  Fly   287 YTAASHYDQESVSPPAVERPRSNMSISSHNVDYSNQSVEDLLLQGNGTAGGNILVGGAASPM--- 348
                   ...||:.|.|.. ....:.|.|..|.|:...||:         ||.......||:
Frog   254 -------QLMSVTIPEVYE-SYQAADSDHKPDTSSSESEDI---------GNEDTAPELSPVLPG 301

  Fly   349 ---------AQSVSQSPAQHDVYTVTEAPDSHVQEVPNSPPYY---------------------- 382
                     .....::...|:...:.....|..::...:.|.:
Frog   302 RIKTFNRDKKTKRRRNGDHHEYEALYNYGCSGSEDAEETKPSFADSGFSKKCHKSCKASFVKIDD 366

  Fly   383 -----EEQNVLTTPMVREQEQQKRQQLKENNKLRRQAGDVILDAGDILVDSSSPKAQRTSIQHST 442
                 .|:|.:.|..:.:.|.|..|:|.|.:.:.....:.|:.:|:         ||:|....|.
Frog   367 RLRRMHEENTMLTKRIIDYENQSVQKLSEISTVLSTLANFIMISGN---------AQKTIPPSSL 422

  Fly   443 QPDVM-VQPMIIKSEPENSSGLMDLM 467
            ..|:. .|..:.:....:.||:...|
Frog   423 TADMTGTQQYVSRGSQCHRSGMWSAM 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsf	NP_001036555.1	HSF	45..148	CDD:214654	46/103 (45%)
Hsf	NP_001036555.1	Vert_HS_TF	<607..711	CDD:284062
hsf2.2	NP_001090859.1	HSF_DNA-bind	10..110	CDD:366106	44/99 (44%)
hsf2.2	NP_001090859.1	bHLH_SF	369..413	CDD:381792	10/52 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1154048at2759
OrthoFinder	1	1.000	-	-		FOG0000255
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020