DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sema5c and SEMA5A

DIOPT Version :9

Sequence 1:NP_611293.3 Gene:Sema5c / 37066 FlyBaseID:FBgn0284221 Length:1093 Species:Drosophila melanogaster
Sequence 2:NP_003957.2 Gene:SEMA5A / 9037 HGNCID:10736 Length:1074 Species:Homo sapiens


Alignment Length:1116 Identity:389/1116 - (34%)
Similarity:571/1116 - (51%) Gaps:128/1116 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 WLLLILSLLTLEGPQPSTGSGYTTKSSVDLLENDSRYISYQDLMSTAKRFYDPETTWYSEMLFDV 80
            ||...|.|..|..|:        .:.:......:...|||:::....:.|.......:|::.||.
Human     9 WLFSSLGLWRLAHPE--------AQGTTQCQRTEHPVISYKEIGPWLREFRAKNAVDFSQLTFDP 65

  Fly    81 ARNQVIVGARDTLYRMSF-DLEPLERASWGATPSEIAMCQAKGQSERWCRNYVRVLHSYGENQLY 144
            .:.:::||||:.|:|:.. ||..::...|....:....|.:||:|:..|:||:||| ..|.::|:
Human    66 GQKELVVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVL-LVGGDRLF 129

  Fly   145 ACGTNAFQPSCSWRQMENLT-VTGVDSGVVKCPFHPQANSTSLLQSNGQLFVGTATDFSGSDVAI 208
            .||||||.|.|:.|.:.||| :....||:.:||:.||.|||:||.:.|:|:..||.||.|.|.||
Human   130 TCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAI 194

  Fly   209 LRT-GVESNKRFLRTKQYNNNWLSGAQFVGSFEAGHFVYFLLRESAAEHMSCGKVIYSRVARVCK 272
            .|: |:...   |||.|||:.||:...||.|::.|:|.||..||:|.|| .|||.::||.|||||
Human   195 YRSLGILPP---LRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEH-DCGKTVFSRAARVCK 255

  Fly   273 NDVGGGGQLLRDNWTSFLKARLNCSLPGEYPYYFDEIQGMTYAESESILYATFRTSGSSIFGSAV 337
            ||: ||..||.|.||:|:|||||||.|||.|:|::|:|...:.....::|..|.|:.:||..|||
Human   256 NDI-GGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPELDLIYGIFTTNVNSIAASAV 319

  Fly   338 CAYNLSSINAAFDGPFKQQEHSDAAWKTVNTNQRSQFQCGTSSIGHWL--------ESSRYQLMD 394
            |.:|||:|..||.||||.||:|.:||... .|....|||||...|.::        ::.::.||.
Human   320 CVFNLSAIAQAFSGPFKYQENSRSAWLPY-PNPNPHFQCGTVDQGLYVNLTERNLQDAQKFILMH 383

  Fly   395 EAVQPIGAEPLYHSKLEQFGRLALDIINTKTEQVHVLFVASSGNHIKKLSVKYDGDGVQTCLVEL 459
            |.|||:...|.:.....:|..:|:|::..:...||::::|:....|||:.|..:.......|.|:
Human   384 EVVQPVTTVPSFMEDNSRFSHVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQTSSSCLLEEI 448

  Fly   460 WQADDTGTSSLLNMAYLKVSDSLYLGTDLALTRIPAQHCSRHVSQSSCLNSMDPYCGWNELVERC 524
            ....:.....:.::..|.....|::|....:.:||.:.|..:.::|:|:.:.||||||:.::::|
Human   449 ELFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRCQFYRTRSTCIGAQDPYCGWDVVMKKC 513

  Fly   525 MPQPQDSSVLQHWHQAPQITCPVLNAPIDGGWSTWSPWAVCQQHE-QPDSNCQCRQRSCNNPQPQ 588
            ....:..|:.| |.|:.. .||..|..:||.:..||||..|...: ....:|.||.|||::|.||
Human   514 TSLEESLSMTQ-WEQSIS-ACPTRNLTVDGHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQ 576

  Fly   589 HGGATCEGISTQVTNCTQHGGWTEWSAWSPCSQTCGIAVKIRRRTCGNPRPAFGGRTCVGSEQSE 653
            .||..|||...::.||:::||||.|::|||||.||||..::|:|:|.||.|..|||.|||..:.|
Human   577 CGGWQCEGPGMEIANCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREE 641

  Fly   654 MYCRHLPPCPVAKPQSVDGGWGPWGEWSECSAQCGGGFRMRRRECNDPAPLNGGMECPGCRLDYE 718
            .||.....||   |.....||||   |..|:||||||.:.|||.|.:      |.:|.||.::|:
Human   642 RYCNEHLLCP---PHMFWTGWGP---WERCTAQCGGGIQARRRICEN------GPDCAGCNVEYQ 694

  Fly   719 ECNMQSCQEVRKLSAWTPWLTVTGSGNSSEPHMERRFRFVCRATSPDPSSVRIGLPKEESRNCHA 783
            .||...|.|::|.:.||||..|..|.|..  |.|:|||:.|:|...||:.:.:|..:.|.|.|.:
Human   695 SCNTNPCPELKKTTPWTPWTPVNISDNGG--HYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSS 757

  Fly   784 DGSCQRQVDHDSAD----------------SDAADWSPCSVSCGGGVQQRHR------------- 819
            ||:.....|..|.|                |....||.||..|..|::.|.|             
Human   758 DGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMP 822

  Fly   820 --GRGSQSRVCNIHACPAEEQLSSNSLDNELEHGEWGCWSEWSACSVTCGLGLRRRTRRC----- 877
              |...:.:.|||..||.:              |.|.|||.|:.||.|||.|...|||.|     
Human   823 CLGPSLEYQECNILPCPVD--------------GVWSCWSPWTKCSATCGGGHYMRTRSCSNPAP 873

  Fly   878 LAGHDRLCQGRALEEQKCEMVPCEDFLGWSAWSEWSSCSSDGIRLRHRRCLVEQPGSMECRGAEF 942
            ..|.| :|.|...||..|...||.:  .||.||:||.|.:.|:::|.|:|::..|...:|.|...
Human   874 AYGGD-ICLGLHTEEALCNTQPCPE--SWSEWSDWSECEASGVQVRARQCILLFPMGSQCSGNTT 935

  Fly   943 EKTACV--PNECEETQTASTATLP----------IVIFVGLLFTVACCLAT---YRFTKKRFMLS 992
            |...||  .|...|...|.::::.          .:|.|||..::..||.|   |.:. :|:...
Human   936 ESRPCVFDSNFIPEVSVARSSSVEEKRCGEFNMFHMIAVGLSSSILGCLLTLLVYTYC-QRYQQQ 999

  Fly   993 AEEALNKTTTTTASFDT-YPNQYSSLPTKDYYDQRPKRQSSFRMPAKTSNLGNGNGTLNRNNMHQ 1056
            :.:|......:.|..:| ..|..:.|   |.||      |...:.|...|    |..|...|.:.
Human  1000 SHDATVIHPVSPAPLNTSITNHINKL---DKYD------SVEAIKAFNKN----NLILEERNKYF 1051

  Fly  1057 NNTPKVLAKTY 1067
            |  |.:..|||
Human  1052 N--PHLTGKTY 1060

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema5cNP_611293.3 Sema_5C 65..496 CDD:200526 169/441 (38%)
PSI 497..546 CDD:279745 14/48 (29%)
TSP1 556..607 CDD:214559 21/51 (41%)
TSP1 610..663 CDD:214559 27/52 (52%)
TSP1 674..725 CDD:214559 22/50 (44%)
TSP1 802..834 CDD:214559 12/46 (26%)
TSP1 853..901 CDD:214559 23/52 (44%)
TSP1 906..953 CDD:214559 18/48 (38%)
SEMA5ANP_003957.2 Sema_5A 50..485 CDD:200524 169/441 (38%)
PSI 486..533 CDD:279745 14/48 (29%)
TSP1 544..595 CDD:214559 21/50 (42%)
TSP1 598..651 CDD:214559 27/52 (52%)
TSP1 656..702 CDD:214559 23/54 (43%)
TSP1 787..839 CDD:214559 13/51 (25%)
TSP1 844..896 CDD:214559 23/52 (44%)
TSP1 899..940 CDD:214559 15/40 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 305 1.000 Domainoid score I1371
eggNOG 1 0.900 - - E1_KOG3611
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 674 1.000 Inparanoid score I731
Isobase 1 0.950 - 0 Normalized mean entropy S5741
OMA 1 1.010 - - QHG47498
OrthoDB 1 1.010 - - D41799at33208
OrthoFinder 1 1.000 - - FOG0003495
OrthoInspector 1 1.000 - - otm40840
orthoMCL 1 0.900 - - OOG6_106097
Panther 1 1.100 - - O PTHR11036
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R9633
SonicParanoid 1 1.000 - - X2388
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.820

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