DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema5c and sema4e

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	NP_001077334.1	Gene:	sema4e / 796377	ZFINID:	ZDB-GENE-990715-7	Length:	766	Species:	Danio rerio

Alignment Length:	695	Identity:	185/695 - (26%)
Similarity:	302/695 - (43%)	Gaps:	112/695 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLLILSLLTLEGPQPSTGSGYTTKSSVDLLENDSRYISYQDLMSTAKRFYDPETTW-YSEMLFDV 80
            ||.:|.:|.:..|...||.   ..|::|.|...:..|.     |...|.:..|..| |:.||...
Zfish     4 LLAVLCVLYVWSPAMLTGG---LGSTLDSLPRKTVPIG-----SNGGRLFREEGIWNYTTMLLRD 60

  Fly    81 ARNQVIVGARDTLYRMSFDLEPLERA--SWGATPSEIAMCQAKGQ-SERWCRNYVRVLHSYGENQ 142
            ..|.:|:|||:.::.:..|...:::|  .|..|..:...|..||: :...|:||:|:||...:.:
Zfish    61 DLNLLILGAREAIFALDLDDITIKKAMLKWEVTRDQQNDCSNKGKDATNDCKNYIRILHKKDDGR 125

  Fly   143 LYACGTNAFQPSCSWRQMEN--LTVTGVDSGVV-KCPFHPQANSTSLLQSNGQLFVGTATDFSGS 204
            :|.|||.||.|:|.:....:  ||:..:..... ||||.|....||.: .:|..:..|:.:|.||
Zfish   126 MYVCGTKAFNPTCGYLSYADGKLTLEILQEDTKGKCPFDPFQRYTSAM-VDGAYYSATSMNFRGS 189

  Fly   205 DVAILRTGVESNKRFLRTKQYNNNWLSGAQFVGSFEAGHF-------------VYFLLRESAAEH 256
            :..::|:..||    :|| ::.:.|||...|:   ...|.             :|....|:|.|:
Zfish   190 EPVMMRSTEES----IRT-EFTSTWLSEPNFI---HMAHIPEGQSNPDGDDDKIYLFFSETAVEY 246

  Fly   257 MSCGKVIYSRVARVCKNDVGGGGQLLRDNWTSFLKARLNCSLPG-EYPYYFDEIQGMTYAE-SES 319
            .||.||..||||||||.|: ||.:.|:..|||||||||:|.:|. ..|....::..:...: :..
Zfish   247 ESCTKVDVSRVARVCKGDL-GGQRTLQKKWTSFLKARLDCQVPNTNLPLLVQDVFHLCPDDWTTC 310

  Fly   320 ILYATFRTSGSSIFGSAVCAYNLSSINAAFD-GPFK---QQEHSDAAW-------------KTVN 367
            :.||.|.....|...||||:|.:..|...|. |.||   ..|.|...|             ..::
Zfish   311 VFYAVFTPQSDSSQYSAVCSYKIEDIKTVFSKGKFKAPFNVETSFVKWVMYSGELPDPRPGACID 375

  Fly   368 TNQRSQFQCG-TSSIGHWLESSRYQ------LMDEAVQPIGAEPLYHSKLEQFGRLALDIINTKT 425
            .:.|   |.| |.|:.  |.....|      |||:||  ...:||...:...|.|:.:.......
Zfish   376 NHAR---QKGITKSLE--LPDKTLQFVKDKPLMDQAV--TAEQPLLVKRGAAFTRIVVTTATALN 433

  Fly   426 EQVH-VLFVASSGNHIKKLSVKYDGDGVQTCLVELWQADDTGTSSLLNMAYLKVSDS---LYLGT 486
            ...| |:|:.:....:.| :|.|:|:.|....::|::..:.       :..|::|.|   ||:|:
Zfish   434 GTSHQVMFIGTKSGSVLK-AVNYNGEMVIMEEIQLFEPSEP-------IKILRLSSSKKQLYVGS 490

  Fly   487 DLALTRIPAQHCSRHVSQSSCLNSMDPYCGWNELVERC-----MPQPQDSSVLQHWHQAPQITCP 546
            ::.:.::....|.::.:...|:.:.||:|||:...|.|     :.:.:.|:|:|.........||
Zfish   491 EVGVVQLSISECGQYQTCLDCVLARDPHCGWDLDTEHCATINSIHRTRSSTVIQSLSDGDASQCP 555

  Fly   547 VL--NAPID-----G-----GWSTWS-----PWAVCQQHEQPDSNCQCRQRSC---NNPQPQHGG 591
            .:  :.|::     |     |...:|     .|.:..:..:|.:..|......   |......|.
Zfish   556 AIGVSKPVNISFYHGNTVKLGCQPYSNLAQVEWQLNGEPIKPSNTIQILSDGLMIFNASLDATGY 620

  Fly   592 ATCEGIST--QVTNCTQHGGWTEWSAWSPCSQTCGI-AVKIRRRT 633
            ..|..|.|  |....|||..: :...||....|..: .||.:.||
Zfish   621 YICSSIETVSQRKYQTQHVAY-DVKMWSESGTTASLHHVKEKERT 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	135/480 (28%)
		PSI	497..546	CDD:279745	12/53 (23%)
		TSP1	556..607	CDD:214559	11/60 (18%)
		TSP1	610..663	CDD:214559	7/25 (28%)
		TSP1	674..725	CDD:214559
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
sema4e	NP_001077334.1	Sema_4E	45..500	CDD:200521	135/479 (28%)
		PSI	501..555	CDD:214655	12/53 (23%)
		Ig	567..640	CDD:299845	15/72 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	724..750
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810