DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema5c and SEMA4A

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	NP_001180229.1	Gene:	SEMA4A / 64218	HGNCID:	10729	Length:	761	Species:	Homo sapiens

Alignment Length:	593	Identity:	166/593 - (27%)
Similarity:	265/593 - (44%)	Gaps:	101/593 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LKLPKMFSQLWLLL---ILSLLTLEGPQPSTGSG----------YTTKSSVDLLENDSRYISYQD 57
            :.||.:....|.||   :..||.|..|..:.|.|          |.        .::.|.:|:
Human     1 MALPALGLDPWSLLGLFLFQLLQLLLPTTTAGGGGQGPMPRVRYYA--------GDERRALSF-- 55

  Fly    58 LMSTAKRFYDPETTWYSEMLFDVARNQVIVGARDTLYRMSFDLEPLERAS----WGATPSEIAMC 118
                   |:......:..:|.....|.:.||||:.:..:......:.|..    |.|:..:.:.|
Human    56 -------FHQKGLQDFDTLLLSGDGNTLYVGAREAILALDIQDPGVPRLKNMIPWPASDRKKSEC 113

  Fly   119 QAKGQS-ERWCRNYVRVLHSYGENQLYACGTNAFQPSCSWRQMEN-----LTVTGVDSGVVKCPF 177
            ..|.:| |..|.|::|||.||....||.|||.||.|:|::.::::     ::...|..|..:.||
Human   114 AFKKKSNETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQSPF 178

  Fly   178 HPQANSTSLLQSNGQLFVGTATDFSGSDVAILRT----GVESNKRFLRTKQYNNNWL-SGAQFVG 237
            .|....|::| .:|.|:.||..:|.||:..::||    .|.....|||       || ..|.||.
Human   179 DPAHKHTAVL-VDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNFLR-------WLHHDASFVA 235

  Fly   238 SFEAGHFVYFLLRESAAEHMSCGKVIYSRVARVCKNDVGGGGQLLRDNWTSFLKARLNCSLPGEY 302
            :..:...|||...|:|:|.....::..||||||||||| ||.:||:..||:||||:|.|:.||:.
Human   236 AIPSTQVVYFFFEETASEFDFFERLHTSRVARVCKNDV-GGEKLLQKKWTTFLKAQLLCTQPGQL 299

  Fly   303 PYYFDEIQGMTYAESESI--LYATFRTSGSSIFG---SAVCAYNLSSINAAFDGPFKQQEHSDAA 362
            |:.......:..|:|.:.  :||.| ||...:.|   |||||::|..|...|.|.:|:.....:.
Human   300 PFNVIRHAVLLPADSPTAPHIYAVF-TSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKETSR 363

  Fly   363 WKTV---NTNQRSQFQCGTSSIGHWLESS-----RYQLMDEAVQPIGAEPLYHSKLEQFGRLALD 419
            |.|.   .||.|.    |:.|:|...:.:     .:.||||  |.:|...|..|.:| :.|||::
Human   364 WTTYRGPETNPRP----GSCSVGPSSDKALTFMKDHFLMDE--QVVGTPLLVKSGVE-YTRLAVE 421

  Fly   420 IINTKTEQVH-VLFVASSGNHIKKLSVKYDGDGVQTCLVELWQADDTGTSSLLNMAYLKVSDSLY 483
            .........| |:::.::...:.|..|  .||.....:.|:....|  ...:.|:.......:::
Human   422 TAQGLDGHSHLVMYLGTTTGSLHKAVV--SGDSSAHLVEEIQLFPD--PEPVRNLQLAPTQGAVF 482

  Fly   484 LGTDLALTRIPAQHCSRHVSQSSCLNSMDPYCGWNELVERCMPQPQDSSVLQHWHQAPQITCPVL 548
            :|....:.|:|..:||.:.|...|:.:.||:|.|:       |:.:              ||.:|
Human   483 VGFSGGVWRVPRANCSVYESCVDCVLARDPHCAWD-------PESR--------------TCCLL 526

  Fly   549 NAPIDGGW 556
            :||....|
Human   527 SAPNLNSW 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	137/459 (30%)
		PSI	497..546	CDD:279745	10/48 (21%)
		TSP1	556..607	CDD:214559	1/1 (100%)
		TSP1	610..663	CDD:214559
		TSP1	674..725	CDD:214559
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
SEMA4A	NP_001180229.1	Sema_4A	55..495	CDD:200517	137/469 (29%)
		PSI	496..541	CDD:214655	15/60 (25%)
		Ig	566..638	CDD:353325
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	722..749
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41799at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820