DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema5c and SEMA4G

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	NP_060363.2	Gene:	SEMA4G / 57715	HGNCID:	10735	Length:	843	Species:	Homo sapiens

Alignment Length:	690	Identity:	180/690 - (26%)
Similarity:	274/690 - (39%)	Gaps:	168/690 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MFSQLWLLLILSLLTLEG-PQPSTGSGYTTKSSVDLLENDSRYISYQDLMSTAKRFYDPETTWYS 74
            |:.:||.|| ||:||... |.||     ..:.|.:|.......|.|::|..|  |.:..:...||
Human     1 MWGRLWPLL-LSILTATAVPGPS-----LRRPSRELDATPRMTIPYEELSGT--RHFKGQAQNYS 57

  Fly    75 EMLFDVARNQVIVGARDTLYRMSF-DL--EPLERASWGATPSEIAMCQAKGQSERW-CRNYVRVL 135
            .:|.:.|..:::||||..|:.:|. |:  ...:...|.|:|...:.|..||::.:. |.|:||.|
Human    58 TLLLEEASARLLVGARGALFSLSANDIGDGAHKEIHWEASPEMQSKCHQKGKNNQTECFNHVRFL 122

  Fly   136 HSYGENQLYACGTNAFQPSCSWRQMENLTV-TGVDSGVVKCPFHPQANSTSLLQSNGQLFVGTAT 199
            .......||||||:||||.|:....|..|: |..:.|..|||:.|....|.|: .:|.|:..|..
Human   123 QRLNSTHLYACGTHAFQPLCAAIDAEAFTLPTSFEEGKEKCPYDPARGFTGLI-IDGGLYTATRY 186

  Fly   200 DF-SGSDVAILRTGVESNKRFLRTKQYNNNWLSGAQFVGSFEAGHFVYFLLRESAAEHMSCGKVI 263
            :| |..|:...|     :...|||::...:||:.|:||.|        .|:|||.|..:.....:
Human   187 EFRSIPDIRRSR-----HPHSLRTEETPMHWLNDAEFVFS--------VLVRESKASAVGDDDKV 238

  Fly   264 Y------------------------SRVARVCKNDVGGGGQLLRDNWTSFLKARLNCSLPGEYPY 304
            |                        :|||||||.|: ||.::|:..|||||||||.|.:|
Human   239 YYFFTERATEEGSGSFTQSRSSHRVARVARVCKGDL-GGKKILQKKWTSFLKARLICHIP----- 297

  Fly   305 YFDEIQGMTYAESESI----LYATF--RTSGSSIFGSAVCAYNLSSINAAFDGPFKQQEHSDAAW 363
            .::.::|:...::|:.    .||.|  .|...::..||:|.|:|:.|.|.|.||:.:.:.....|
Human   298 LYETLRGVCSLDAETSSRTHFYAAFTLSTQWKTLEASAICRYDLAEIQAVFAGPYMEYQDGSRRW 362

  Fly   364 KTVNTNQRSQFQCGT------SSIGHWLESSRYQ-----------------LMDEAVQPIGAEPL 405
                    .:::.|.      |.|...|.|..|.                 ||...|.|....||
Human   363 --------GRYEGGVPEPRPGSCITDSLRSQGYNSSQDLPSLVLDFVKLHPLMARPVVPTRGRPL 419

  Fly   406 YHSKLEQFGRLA-------------LDIINTKTEQVHVLFVASSGNH-IKKLSVKYDGDGVQTCL 456
            ...:..::..|.             |..:.|....:|...|..||.| |::..|..:...|:..:
Human   420 LLKRNIRYTHLTGTPVTTPAGPTYDLLFLGTADGWIHKAVVLGSGMHIIEETQVFRESQSVENLV 484

  Fly   457 VELWQADDTGTSSLLNMAYLKVSDSLYLGTDLALTRIPAQHCSRHVSQSSCLNSMDPYCGWNELV 521
            :.|.|                  .|||:|....:.::|...|||:.|...|:.:.||||||:...
Human   485 ISLLQ------------------HSLYVGAPSGVIQLPLSSCSRYRSCYDCILARDPYCGWDPGT 531

  Fly   522 ERCMPQPQDSSVLQHWHQAPQITCPVLNAPIDGGWSTWSPWAVCQQHEQPDSNCQCRQRSCNNPQ 586
            ..|..                       |......|..|..|:.|..|:.:..|: ..|....|.
Human   532 HACAA-----------------------ATTIANRSQGSRTALIQDIERGNRGCE-SSRDTGPPP 572

  Fly   587 PQHGGATCEGISTQVTNCTQHGGWTEWSAWSPCSQTCGIA 626
            |....:...|....:                ||.|...:|
Human   573 PLKTRSVLRGDDVLL----------------PCDQPSNLA 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	134/503 (27%)
		PSI	497..546	CDD:279745	12/48 (25%)
		TSP1	556..607	CDD:214559	10/50 (20%)
		TSP1	610..663	CDD:214559	4/17 (24%)
		TSP1	674..725	CDD:214559
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
SEMA4G	NP_060363.2	Sema_4G	47..506	CDD:200523	135/504 (27%)
		PSI	507..557	CDD:307546	17/72 (24%)
		Ig_Sema4B_like	572..655	CDD:143280	6/41 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	728..782
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810