DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sema5c and SEMA6A

DIOPT Version :10

Sequence 1:NP_611293.3 Gene:Sema5c / 37066 FlyBaseID:FBgn0284221 Length:1093 Species:Drosophila melanogaster
Sequence 2:XP_006714726.1 Gene:SEMA6A / 57556 HGNCID:10738 Length:1052 Species:Homo sapiens


Alignment Length:685 Identity:191/685 - (27%)
Similarity:311/685 - (45%) Gaps:150/685 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 LLLILSLLTLEG---PQPS-----TGSGYTTKSSVDLLENDSRYISYQDLMSTAKRFYDPETTWY 73
            |||..:||...|   |:.|     :...||.:..|        ::.::...:|.:|..      .
Human     6 LLLYFTLLHFAGAGFPEDSEPISISHGNYTKQYPV--------FVGHKPGRNTTQRHR------L 56

  Fly    74 SEMLFDVARNQVIVGARDTLYRMSFDLEPLE------RASWGATPSEIAMCQAKGQSERWCRNYV 132
            ...:..:....:.:.|||.:|.:..|....|      :.:|.:..:::..|:.||:.:..|.|::
Human    57 DIQMIMIMNGTLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNFI 121

  Fly   133 RVLHSYGENQLYACGTNAFQPSCSWRQMENLTVTGVD-SGVVKCPFHPQANSTSLLQSNGQLFVG 196
            :||....::.|:.||||||.|||...:|:.|...|.: ||:.:||:..:..:.:|. ::|:|:..
Human   122 KVLLKKNDDALFVCGTNAFNPSCRNYKMDTLEPFGDEFSGMARCPYDAKHANVALF-ADGKLYSA 185

  Fly   197 TATDFSGSDVAILRTGVESNKRFLRTKQYNNNWLSGAQFVGSFEAGHFVYFLLRESAAEHMSCGK 261
            |.|||...|..|.|:..||..  |||.::::.||....||.:.:.|.::||..||.|.|:.:.||
Human   186 TVTDFLAIDAVIYRSLGESPT--LRTVKHDSKWLKEPYFVQAVDYGDYIYFFFREIAVEYNTMGK 248

  Fly   262 VIYSRVARVCKNDVGGGGQLLRDNWTSFLKARLNCSLPGEYPYYFDEIQGMT---YAESESILYA 323
            |::.|||:|||||:||..::|...||||||||||||:||:..:||:.:|.:|   ......::.|
Human   249 VVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVIRINGRDVVLA 313

  Fly   324 TFRTSGSSIFGSAVCAYNLSSINAAFDGPFKQQEHSDAAWKTVNTNQ----RSQFQCGTSSIGHW 384
            ||.|..:||.|||||||::..|.:.|.|.||:|:..|:.|..|...:    |.....|:||:..:
Human   314 TFSTPYNSIPGSAVCAYDMLDIASVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSSSLERY 378

  Fly   385 LESSRY-----------QLMDEAVQPIGAEPLYHSKLEQF--GRLALD----------IINTKTE 426
            ..|:.:           .||||||..|...|.:...:.::  .::|:|          ::...:|
Human   379 ATSNEFPDDTLNFIKTHPLMDEAVPSIFNRPWFLRTMVRYRLTKIAVDTAAGPYQNHTVVFLGSE 443

  Fly   427 QVHVL-FVASSGN--------HIKKLSV----KYDGDGVQTCLVELWQADDTGTSSLLNMAYLKV 478
            :..:| |:|..||        .::::||    |...|||:             ...::.|...:.
Human   444 KGIILKFLARIGNSGFLNDSLFLEEMSVYNSEKCSYDGVE-------------DKRIMGMQLDRA 495

  Fly   479 SDSLYLGTDLALTRIPAQHCSRH-VSQSSCLNSMDPYCGW------------------NELVER- 523
            |.|||:.....:.::|...|.|| ..:.:|:.|.||||||                  .:.:|| 
Human   496 SSSLYVAFSTCVIKVPLGRCERHGKCKKTCIASRDPYCGWIKEGGACSHLSPNSRLTFEQDIERG 560

  Fly   524 -------CMPQPQDSSVLQHWHQAPQITCPVLNAPIDGGWSTWSPW---AVCQQHEQPDSNCQCR 578
                   |    .:|.|..:......|.|.|:   |..|||.||.|   ::.......||..|  
Human   561 NTDGLGDC----HNSFVALNEANILFIMCMVI---ILQGWSFWSCWHSSSLLPSTTTSDSTAQ-- 616

  Fly   579 QRSCNNPQPQHGGATCEGISTQVTNCTQHGGWTEW 613
                            ||..::       ||..:|
Human   617 ----------------EGYESR-------GGMLDW 628

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema5cNP_611293.3 Sema_5C 65..496 CDD:200526 144/480 (30%)
PSI 497..546 CDD:396154 17/75 (23%)
TSP1 556..607 CDD:214559 10/53 (19%)
TSP1 610..663 CDD:214559 1/4 (25%)
TSP1 674..725 CDD:214559
TSP1 802..834 CDD:214559
TSP1 853..901 CDD:214559
TSP1 906..953 CDD:214559
SEMA6AXP_006714726.1 Sema_6A 48..513 CDD:200527 146/486 (30%)
PSI 514..>544 CDD:396154 11/29 (38%)
Blue background indicates that the domain is not in the aligned region.

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