DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema5c and sema4ba

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	NP_001121824.1	Gene:	sema4ba / 572261	ZFINID:	ZDB-GENE-070705-31	Length:	830	Species:	Danio rerio

Alignment Length:	923	Identity:	225/923 - (24%)
Similarity:	359/923 - (38%)	Gaps:	242/923 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MLILKLPKMFSQLWLLLILSLLTLEGPQPSTGSGYTTKSSVDLLENDSRYISYQDLMSTAKRFYD 67
            |..|.:.::|    .|.:|::| |.|...|.....|.:.|          .||.....:||||..
Zfish     1 MWTLNMTRVF----FLFLLNVL-LVGRCQSAEDDVTPRLS----------FSYNANERSAKRFSP 50

  Fly    68 PETTWYSEMLFDVARNQVIVGARDTLYRMSF-DLEPLE---RASWGATPSEIAMCQAKGQSERW- 127
            .....|:.:|.....|.:.||||:||:.::. |:...:   ..:|.....:...|..||:..:.
Zfish    51 SGVFNYTSLLLSKEDNMLYVGARETLFALNISDISRTQMQRNLTWSTPQRKRDECSFKGKDLKTD 115

  Fly   128 CRNYVRVLHSYGENQLYACGTNAFQPSCSW---RQMENLTVTGVDSGVV-------KCPFHPQAN 182
            |.||:::|.......||.|||.||.|.|::   ....|.::...:.|.:       :||::|:..
Zfish   116 CFNYIKILLRVNSTHLYVCGTYAFSPICTYIVSTNTSNFSLVRNEVGEIMTEDGRSRCPYNPEYK 180

  Fly   183 STSLLQSNGQLFVGTATDFSGSDVAILRTGVESNKRFLRTKQYNNNWLSGAQFVG------SFEA 241
            ||::: ::|:|:.||.::|.|:|..|.::..:...  |:|:. :.|||....|||      |...
Zfish   181 STAIM-ADGELYAGTVSNFQGNDPIIYKSLGQGTA--LKTEN-SLNWLQDPAFVGSAYIQESLPK 241

  Fly   242 GHFV------YFLLRESAAEHMSCGKVIYSRVARVCKNDVGGGGQLLRDNWTSFLKARLNCSLPG 300
            |:.|      ||...|:..|.......|.||:|||||.| .||.::|:..||:||||:|.||||.
Zfish   242 GNAVGDDDKIYFFFSEAGKEFDFFDNTIVSRIARVCKGD-KGGERVLQKKWTTFLKAQLLCSLPD 305

  Fly   301 E-YPYYFDEIQGM---TYAESE---SILYATFRT------SGSSIFGSAVCAYNLSSINAAFDGP 352
            : :|  |:.||.|   |.::.:   ::.|..|.:      |||    |||||:.:..:..||:|.
Zfish   306 DGFP--FNIIQDMFVLTPSKEDWKKTMFYGVFTSQWYKGASGS----SAVCAFTMDQVEEAFNGR 364

  Fly   353 FKQQEHSDAAWKTVN------------TN-QRSQFQCGTSSIGHWLES-----SRYQLMDEAVQP 399
            :::.......|.|.|            || .|:|   |.||..|..:.     ..:.|||..::
Zfish   365 YREVNRETQQWYTYNHPVPEPRPGACITNTARAQ---GISSSLHMPDRVLNFVKDHFLMDNVIR- 425

  Fly   400 IGAEPLYHSKLEQFGRLALDIINTKTEQVHVLFVASSGNHI-KKLSVKYDGDGVQTCLVELWQAD 463
              ::||...:..::.:||:..:....:...|||:.:....| |.::||.....::..::
Zfish   426 --SQPLLLKRNVRYTQLAVHRVQALHKTYDVLFIGTDDGRIHKAINVKNKMYIIEELVI------ 482

  Fly   464 DTGTSSLLNMAYLKVSDS---LYLGTDLALTRIPAQHCSRHVSQSSCLNSMDPYCGWNELVERCM 525
               .....::.::::.|.   |::.:...|..||..:||.:.|...|:.|.||||.|..  ::|.
Zfish   483 ---FPEPQSVQHIELDDEKGLLFVSSYSGLVEIPLANCSNYQSCGECVLSRDPYCAWTG--KQCS 542

  Fly   526 PQPQDSSVLQHWHQ------------------APQI-TCPVLNAPIDGGWSTWSPWAVCQQHEQP 571
            .....||..| |.|                  .|:: .|.|:..|  ....|..|   |:..
Zfish   543 NVKHASSKSQ-WQQDVEDANTAICKMPSPRSGRPRVPACHVVEIP--ANTFTVLP---CKLR--- 598

  Fly   572 DSNCQCRQRSCNN-------PQPQHGGATCEGISTQVTNCTQHGGWTEWSAWSPCSQTCGIAVKI 629
             ||...|:...::       |.|. ||..   :..||.....:..|:|.
Zfish   599 -SNLAARRWEYSDTAERFVYPSPD-GGLV---VVAQVDRQENYACWSEE---------------- 642

  Fly   630 RRRTCGNPRPAFGGRTCVGSE-QSEMYCRHLPPCPVAKPQSVDGG--WGPWGE---WSECSAQCG 688
                 ||.|..... .||.:| :|...........|.:.:::..|  |.|...   |:|....|.
Zfish   643 -----GNYRQLLAS-YCVKAEHESTTLTGRSRTQQVTQGETILPGETWSPQKTKTYWNELIVVCA 701

  Fly   689 ------------GGFRMRRR--------EC--------------NDPAPLNGGMECPG------- 712
                        ..:|.|.|        ||              .:..||||....|.
Zfish   702 LLVFSLVVLSLFVAYRNRDRMKSMLKEGECPNMQQKKPRIPGKHTESLPLNGNNIPPSVSDHKGY 766

  Fly   713 --------CRLDYEEC----NMQSCQEVRKLSAWTPWLTVTGSGNSSEPHMERRFRFVCRATSPD 765
                    |.....||    |.:|..|..|     ..|||    |..|.|:|      ...|.|.
Zfish   767 QTLNDNYICSTPTHECSSPENSKSFSESEK-----RLLTV----NLKESHVE------ISPTCPR 816

  Fly   766 PSSVRIGLPKEES 778
            | .||:|...::|
Zfish   817 P-RVRLGSEIKDS 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	130/492 (26%)
		PSI	497..546	CDD:279745	17/67 (25%)
		TSP1	556..607	CDD:214559	12/57 (21%)
		TSP1	610..663	CDD:214559	9/53 (17%)
		TSP1	674..725	CDD:214559	19/106 (18%)
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
sema4ba	NP_001121824.1	Sema_4B	47..515	CDD:200518	131/493 (27%)
		PSI	516..565	CDD:214655	16/51 (31%)
		Ig	578..654	CDD:299845	20/110 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41799at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920