Protein Alignment Sema5c and adamts2a

DIOPT Version :10

• Sequence 1: NP_611293.3
• Gene: Sema5c / 37066
• FlyBaseID: FBgn0284221
• Length: 1093
• Species: Drosophila melanogaster
• Sequence 2: XP_700384.4
• Gene: adamts2a / 571682
• ZFINID: ZDB-GENE-070816-3
• Length: 1295
• Species: Danio rerio
• Alignment Length: 1232
• Identity: 231/1232 - (18%)
• Similarity: 348/1232 - (28%)
• Gaps: 513/1232 - (41%)

  Fly   180 QANSTSLLQSNGQLFVGTATDFSGSDVAI---------LRTGVESNKRFLRTKQYNNNWLSGAQF 235
            |.:|..||.|: .|:||..|:...:.|||         :|.|.|  :.|:...:      .|...
Zfish   124 QTHSEPLLPSD-CLYVGYVTNVQDTSVAISNCDGLAGMIRAGQE--EFFIEPLE------RGGDM 179

  Fly   236 VGSFEAG----HFVYFLLRESAAEHMSCGKVIYSRVARVCKNDVGGGGQLLRDNWTSFLKARLNC 296
            .|..|.|    |.||   |.|..:     |...::.|.........||....:.....:|.::|.
Zfish   180 TGEEEGGPGRHHIVY---RSSDIK-----KPAVNQPADFHPRGSPLGGLAALEFLPQHVKKKINS 236

  Fly   297 SLPGEYPYYFDEIQGMTYAESESILYATFRTSGSSIFGSAVCAYNLSSINAAFDGPFKQQEHSDA 361
            ....|  .|.|||..:............|...      ..:..|.|:.:|..      .:.:.|:
Zfish   237 RARRE--TYEDEIFNIEVLLGVDCSVVMFHGR------EHIQKYLLTLMNIV------NEIYQDS 287

  Fly   362 AWKTVNTN-----QRSQFQCGTSSIG--------HWLES-SRYQLMDEAVQPIGAEPLYHSKL-- 410
               |:..:     .|....|.:.|:|        ..||: .|:..:.:......||  ||...
Zfish   288 ---TLGAHINVVLVRIMMLCSSKSMGLIELGNASQSLENVCRWAFLQQKEDKNDAE--YHDHAIF 347

  Fly   411 ---EQFGRLALDIINTKTEQVH---------------VLFVASSGNHIKKLSVKYDGDGVQTCLV 457
               ::||...:......|...|               ...||....|:  |.:::||
Zfish   348 LTRQEFGPTGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHV--LGMEHDG-------- 402

  Fly   458 ELWQADDTGTSSLLNMAYLKVSDSLYLGTDLA-----------LTRIPAQHCSRHVSQSSCLNSM 511
               ||::.|             |.:.:|:.:|           .:|...|...|:::...||..
Zfish   403 ---QANECG-------------DEVPMGSIMAPLVQAAFHRFHWSRCSQQELRRYLNTYDCLRD- 450

  Fly   512 DPYCGWNELVERCMPQPQDSSVLQH-WHQAPQITCPVLNAPID--------------GGWSTWSP 561
            ||:                    .| |...||:  |.|...:|              ..:||:.|
Zfish   451 DPF--------------------DHEWPTLPQL--PGLQYSMDEQCRFDFGMGYMMCTAYSTYDP 493

  Fly   562 WAVCQQHEQPDSNCQCRQRSCNNPQPQHGGATCEGISTQVTNCTQHGGWTEWSAWSPCSQTCGIA 626
                           |:|..|::|:......|.:|.....|.|.
Zfish   494 ---------------CKQLWCSHPENPFFCKTKKGPPIDGTKCA--------------------- 522

  Fly   627 VKIRRRTCGNPRPAFGGRTCVGSEQSEMYCRHLPPCPVAKPQSVDGGWGPWGEWSECSAQCGGGF 691
                           .|:.|.     :.:|..|.|..:    .:||.||.|.::..||..||||.
Zfish   523 ---------------SGKNCF-----KGHCIKLTPDIL----RLDGHWGQWTKFGSCSRTCGGGV 563

  Fly   692 RMRRRECNDPAPLNGGMECPGCRLDYEECNMQSCQEV------RKLSAWTP----------WLTV 740
            |.|.||||:|.|.|||..|.|...:::.||.:.|.|.      .:...|.|          ||..
Zfish   564 RFRTRECNNPVPANGGRTCYGNNYEFQLCNTEECAEALVDFREEQCKMWDPHFEHEGNKHHWLPY 628

  Fly   741 TGSGNSSEPHMERRFRFVC-------------------RATSPDPSSV-------RIG------- 772
                ..|||  :.|.:..|                   |.:..||.||       ::|
Zfish   629 ----EHSEP--DERCQLYCQSKETGDVVSMKRMVHDGTRCSYKDPYSVCVRGECEKVGCDNVIAS 687

  Fly   773 -LPKEESRNCHADGS-CQ--------------------------------------------RQV 791
             |..::...|..|.| |:                                            :..
Zfish   688 ELEDDKCGVCGGDNSTCKIVKGNFTRSTRKPGFLKILEIPRGARHIQIHEFKGTPHILAVKNQAT 752

  Fly   792 DH----DSAD------------------SDAAD-------------------------------- 802
            ||    |..|                  :|..:
Zfish   753 DHLFLNDEGDFPESRTVIEKGVAWEYTNNDDMETVQTTGPLRYGVLIMVQSHSISKVTISYKYIL 817

  Fly   803 --------------------------WSPCSVSCGGGVQQRHRG--RGSQSRVCNIHAC---PAE 836
                                      ||.||..||||.|....|  |.|..::.:...|   |..
Zfish   818 PEDPLSSMENTLPQDDTIYFEWALRKWSHCSKPCGGGKQYTRFGCRRKSDGKMVHRTLCANIPKP 882

  Fly   837 EQLSSNSLDNELEHGEWGCWSEWSACSVTCG-LGLRRRTRRC----LAGHDRLCQGRALEEQKCE 896
            ..:|......|.....| ...||..||.:|| .|.:.|..||    |.|..:....:...:.:.|
Zfish   883 RAISRACNQKECSEPIW-VTGEWEECSKSCGKTGSQTRPVRCVRPELDGSYKAINAKYCNDDRPE 946

  Fly   897 -MVPCEDFLGWSAW--SEWSSCS---SDGIRLRH---------------------RRCL------ 928
             ..||...|..:.|  ..||.||   .:|.:.|.                     |.||
Zfish   947 GRRPCNRQLCPAHWRTGPWSQCSVSCGNGTQERQVMCSTPDNAIGICMDTKPQSVRSCLPAPCPN 1011

  Fly   929 --------------VEQPG----------------------SMECRGAEFEKTACVPNECEETQ- 956
                          .|.|.                      ||.|....:.:..|  ..|.||.
Zfish  1012 DRGNFLIQWLSRADPEFPAPKISSRSRCKGDKSVFCRMEVLSMYCSNPGYRQMCC--KSCSETNY 1074

  Fly   957 ----------TASTATLP-IVIFVGLLFTVACCLAT------YRFTKKRFMLSAEEALNKTTT-- 1002
                      |.:|||.| ..|...|||..:...:|      .|:|......:..:.|.:|||
Zfish  1075 TSQFNLTRPWTYTTATPPKTPIRTTLLFRTSQKPSTTTTPSISRWTDISPTSATTKTLKQTTTIT 1139

  Fly  1003 -TTASFDTYPNQYSSLPTKDYYDQRPKRQSSFRMPAKTSNLGNGNGT--LNRNNMHQNNTPK 1061
             ||.:|..:|         |.:|...:...||......|::.....:  ::.::...:.||:
Zfish  1140 FTTGAFTKHP---------DSFDYEEESSGSFYEDETWSSVSESESSEFISSSSKPWSTTPQ 1192

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	70/373 (19%)
		PSI	497..546	CDD:396154	9/49 (18%)
		TSP1	556..607	CDD:214559	11/50 (22%)
		TSP1	610..663	CDD:214559	5/52 (10%)
		TSP1	674..725	CDD:214559	24/50 (48%)
		TSP1	802..834	CDD:214559	13/94 (14%)
		TSP1	853..901	CDD:214559	15/53 (28%)
		TSP1	906..953	CDD:214559	16/114 (14%)
adamts2a	XP_700384.4	None