DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema5c and sema4ab

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	XP_005170153.1	Gene:	sema4ab / 571290	ZFINID:	ZDB-GENE-060503-363	Length:	836	Species:	Danio rerio

Alignment Length:	965	Identity:	216/965 - (22%)
Similarity:	334/965 - (34%)	Gaps:	301/965 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LEGPQPSTGSGYTTKSSVDLLENDSRYISYQDLMSTAKRFYDPETTWYSEMLFDVARNQVIVGAR 90
            |..|..|.|      .|:.:..||..|.:...|:|      :.|.|             :.||||
Zfish    27 LSFPMGSPG------RSLTVFTNDDSYNATTLLLS------NDEGT-------------LFVGAR 66

  Fly    91 DTLYRMSF---DLEPLERASWGATPSEIAMCQAKGQSERWCRNYVRVLHSYGENQLYACGTNAFQ 152
            ||:..::.   |:...|:..|..:..:...|..||:.:..|.|:||||.......:|||||.||.
Zfish    67 DTILSINISQTDMTLKEKLDWSPSEKDFNDCSMKGKLKMDCHNFVRVLQVLNSTHMYACGTFAFS 131

  Fly   153 PSCSWRQMENLT-VTG----VDSGVVKCPFHP-QANSTSLLQSNGQLFVGTATDFSGSDVAILRT 211
            |.|.:...:..| |||    .:.|..:||:.| |.||.  :..:|:|:.||.:||.|:...|.|.
Zfish   132 PRCIYINSQTFTMVTGPSGKPEEGRGRCPYDPYQKNSA--ITVDGELYTGTVSDFRGTRPVISRH 194

  Fly   212 GVESNKRFLRTKQYNNNWLSGAQFVGS--FEAGHFVYFLLRESAAEHMSCGKVIYSRVARVCKND 274
            ..|.:...|:... ...||....|:.|  ..:...|||...|...|:....|...||||:||.:|
Zfish   195 LSEGSHVDLKLDD-TLGWLEDPTFISSTYIHSEEKVYFFFSEIGKEYDFIDKFTVSRVAQVCTSD 258

  Fly   275 VGGGGQLLRDNWTSFLKARLNCSLPGEYPY-YFDEIQGMT----YAESESILYATFRTSGSSIFG 334
            | ||.:.|:..||:|.||:|.|....|.|| ...::..::    .:|.|::.|..|.:......|
Zfish   259 V-GGQRTLQKRWTTFAKAQLLCQADQELPYNVLQDVISLSPPEGASEDETLFYGIFTSQWRVNLG 322

  Fly   335 -SAVCAYNLSSINAAFDGPFKQQEHSDAAWKT-VNTNQRSQFQCGTSSIGHWLESSRYQ----LM 393
             |||||::|..|...|.|.:|........|.| |.....:..:||..:...  .:.|:.    |.
Zfish   323 RSAVCAFSLKDIKKVFTGRYKVLNRDTLKWSTRVQEQMANPGECGLHNASD--NTLRFVKDNFLA 385

  Fly   394 DEAVQPI----------------------GAEPLYHSKLEQFGRLALDIINTKTEQVHVLFVASS 436
            |::|.|:                      ||...|::.|         .:.|::..:|...:...
Zfish   386 DKSVLPVNQGLTVVSPDKSYSNIAAQRVQGARGKYYTVL---------YLLTESGFLHKTVLLKK 441

  Fly   437 GNH-IKKLSVKYDGDGVQTCLVELWQADDTGTSSLLNMAYLKVS-DSLYLGTDLALTRIPAQHCS 499
            |.| |:::.|.:....|::.|                   |.|| .::.:|:...|..:|..:||
Zfish   442 GAHIIEEIQVFHQPQMVKSLL-------------------LSVSKGAVLIGSSEGLLSVPVSNCS 487

  Fly   500 RHVSQSSCLNSMDPYCGW--------------NELV---------ERCMP--------QPQDSSV 533
            .:.|.:.|:.:.||:|||              |:|.         |:|..        |||::..
Zfish   488 HYRSCAECVLARDPFCGWDLSQRVCKLITTSQNQLAQDVDEGKVSEQCSSVNLRSRSGQPQNTQT 552

  Fly   534 LQHWHQAPQITCPVLNAPIDGGWSTWSPWAVCQQHEQPDSNCQCRQRS----CN----NPQ--PQ 588
            |          ||              |..|.........|.||.:.|    |:    |.|  |:
Zfish   553 L----------CP--------------PGEVLSVSLNEVINLQCPEASNLAKCHWERLNSQLSPK 593

  Fly   589 HGGATCEGISTQVTNCTQHGGWTEWSAWSPCSQTCGIAVKIRRRTCGNPRPAFGGRTCVGSEQSE 653
            ....:..|..:.|...:..|.:...:..:..:||. |...|:::  .||
Zfish   594 IFIQSVNGSLSFVATPSTLGHYLCQAVENGYTQTL-IVYHIKQK--NNP---------------- 639

  Fly   654 MYCRHLPPCPVAKPQSVDGGWGPWGEWSECSAQCGGGFRMRRRECNDPAPLNGGMECPGCRLDYE 718
               ..||..|...|.|.:.     |..:..|..........|.:..||:......:.|
Zfish   640 ---TILPSSPKITPTSAEA-----GNKTPFSTPTAPKHTELRPKPEDPSSTVAHKDSP------- 689

  Fly   719 ECNMQSCQEVRKLSAWTP---------WLTVTGSGNSSE----PHME------------------ 752
                  ....||...:||         |:. ..|||..:    .:::
Zfish   690 ------ATTTRKSKNFTPLISAEEESSWMN-ERSGNFKQVDKPTYLQELVVVSVLLALCVSALLT 747

  Fly   753 ---RRFRFVC-------------------RATSPDPSSVRIGLPKEESRNCHADGSCQRQVDHDS 795
               .|||.||                   .||..:..|:|...|:.|.||    |.......|
Zfish   748 IAFNRFRHVCTSRTIAQTPCSRRDVEKGGSATPQERESLRGHSPRLEKRN----GQAPNGQSH-- 806

  Fly   796 ADSDAADWSPCSVSCGGGVQQRHRGRGSQSRVCNIHACPAEEQLSSNSLDNELEH 850
                              :.|.|.|:.|.:             ||:|.|:....|
Zfish   807 ------------------IGQAHNGKSSIT-------------LSNNMLNGSNGH 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	125/476 (26%)
		PSI	497..546	CDD:279745	17/79 (22%)
		TSP1	556..607	CDD:214559	12/60 (20%)
		TSP1	610..663	CDD:214559	8/52 (15%)
		TSP1	674..725	CDD:214559	6/50 (12%)
		TSP1	802..834	CDD:214559	4/31 (13%)
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
sema4ab	XP_005170153.1	Sema_4	41..484	CDD:200501	130/495 (26%)
		PSI	485..>512	CDD:214655	9/26 (35%)
		Ig	555..631	CDD:299845	17/90 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41799at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820