DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema5c and SEMA3G

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	XP_024309410.1	Gene:	SEMA3G / 56920	HGNCID:	30400	Length:	800	Species:	Homo sapiens

Alignment Length:	593	Identity:	158/593 - (26%)
Similarity:	246/593 - (41%)	Gaps:	117/593 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PKMFSQLWLLLILSLLTLEG------PQPST--------GSGYTTKSSVDLLENDSRYISYQDLM 59
            |..::..||   |..|.|.|      |.||.        |:.....||...:|..|||     |:
Human     3 PSAWAICWL---LGGLLLHGGSSGPSPGPSVPRLRLSYRGAMVRKPSSTMWMETFSRY-----LL 59

  Fly    60 STAKR--FYDPETTW-YSEMLFDVARNQVIVGARDTLYRMSFDL---EPLERASWGATPSEIAMC 118
            |..:.  |..|:.:. ...|..|..|:::.:|..|.||.:..|.   :|.| ..|...|.:...|
Human    60 SANRSAIFLGPQGSLNLQAMYLDEYRDRLFLGGLDALYSLRLDQAWPDPRE-VLWPPQPGQREEC 123

  Fly   119 QAKGQSE-RWCRNYVRVLHSYGENQLYACGTNAFQPSCS-------WRQMENLTVTGVDSGVVKC 175
            ..||:.. ..|.|:||||..:....|.||||.||||:|:       ...:.:|....|:||..:|
Human   124 VRKGRDPLTECANFVRVLQPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEPGSVESGRGRC 188

  Fly   176 PFHPQANSTSLLQSNGQLFVGTATDFSGSDVAILRTGVESNKRFLRTKQYNNNWLSGAQFV---- 236
            |..|.....|.. .:|:|:.|...||.|.:..|.|:|  ..:..||:.. :.:.|...:||
Human   189 PHEPSRPFASTF-IDGELYTGLTADFLGREAMIFRSG--GPRPALRSDS-DQSLLHDPRFVMAAR 249

  Fly   237 ---GSFEAGHFVYFLLRES------AAEHMSCGKVIYSRVARVCKNDVGGGGQLLRDNWTSFLKA 292
               .|.:....|||...|:      .:.|     |..|||.|||.|| .||.::|.:.|::||||
Human   250 IPENSDQDNDKVYFFFSETVPSPDGGSNH-----VTVSRVGRVCVND-AGGQRVLVNKWSTFLKA 308

  Fly   293 RLNCSLPGE--YPYYFDEIQGM----TYAESESILYATFRTSGSSIFGSAVCAYNLSSINAAFDG 351
            ||.||:||.  ...:||:::.:    ..|.....:||.|.|..:...|.|||.|:::.|...|:|
Human   309 RLVCSVPGPGGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFNG 373

  Fly   352 PFKQQEHSDAAWKTVNTNQRSQFQCG------------------TSSIGHWLESSRYQLMDEAVQ 398
            ||   .|.|.          .|.|.|                  |:..|....|:: ...||.:|
Human   374 PF---AHRDG----------PQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTK-DYPDEVLQ 424

  Fly   399 PIGAEPLY-------HSK--------LEQFGRLALDIINTKTEQVHVLFVAS-SGNHIKKLSVKY 447
            ...|.||.       |.:        .:|..::.:|.:..:.....|:|:.: ||:.:|.::::.
Human   425 FARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVLKVIALQA 489

  Fly   448 DGDG-VQTCLVELWQADDTGTSSLLNMAYLKVSDSLYLGTDLALTRIPAQHCSRH-VSQSSCLNS 510
            .|.. .:..::|..|.....| .:..|........||:|:.|.:.::....|..: .:.:.|..:
Human   490 GGSAEPEEVVLEELQVFKVPT-PITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCLA 553

  Fly   511 MDPYCGWN 518
            .||||.|:
Human   554 RDPYCAWD 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	132/496 (27%)
		PSI	497..546	CDD:279745	7/23 (30%)
		TSP1	556..607	CDD:214559
		TSP1	610..663	CDD:214559
		TSP1	674..725	CDD:214559
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
SEMA3G	XP_024309410.1	Sema_3G	67..540	CDD:200516	132/498 (27%)
		PSI	539..585	CDD:214655	7/23 (30%)
		Ig_Semaphorin_classIII	604..694	CDD:143279
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810