DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema5c and sema3b

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	NP_001121818.1	Gene:	sema3b / 567064	ZFINID:	ZDB-GENE-081105-78	Length:	775	Species:	Danio rerio

Alignment Length:	522	Identity:	163/522 - (31%)
Similarity:	258/522 - (49%)	Gaps:	74/522 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 ISYQDL--MSTAKRFYDPETTWYSEMLFDVARNQVIVGARDTLYRMSFD--LEPLERASWGATPS 113
            :||:||  .:..|||....:..:..:|.|..|.::.||||:.|..:|.|  .:..::..|.|...
Zfish    33 LSYKDLQQFNGIKRFDLERSCSFGALLLDEERGRLFVGARNFLLSLSLDNISKQEQKIYWPAPVD 97

  Fly   114 EIAMCQAKGQS-ERWCRNYVRVLHSYGENQLYACGTNAFQPSCSW----RQMEN----LTVTGVD 169
            ....|...|:. ...|.|||:|||.|....||||||.||.|:|::    ::||:    :..:.|:
Zfish    98 WREECNWAGKDINTDCVNYVKVLHHYNRTHLYACGTGAFHPTCAYVEVGQKMEDHVFRIDPSLVE 162

  Fly   170 SGVVKCPFHPQANSTSLLQSNGQLFVGTATDFSGSDVAILRTGVESNKRFLRTKQYNNNWLSGAQ 234
            .|..|.|:.|:..|.|:|..: :|:.|.|||..|.|..|.|:  ...|..:||:|:::.||:..:
Zfish   163 DGKGKSPYDPRHTSASVLIGD-ELYAGVATDLMGRDFTIFRS--MGQKPSIRTEQHDSRWLNEPK 224

  Fly   235 FVGSFEAGHF-------VYFLLRESAAEHMSCGKVIYSRVARVCKNDVGGGGQLLRDNWTSFLKA 292
            |:.:|.....       |:|..||:|.|....|||.|||:.::|:||:||...|: :.||:||||
Zfish   225 FIAAFGVPESDNPDDDKVFFFFRETAVEAQGFGKVTYSRIGQLCRNDMGGQRSLV-NKWTTFLKA 288

  Fly   293 RLNCSLPGE--YPYYFDEIQGM----TYAESESILYATFRTSGSSIFGSAVCAYNLSSINAAFDG 351
            ||.||:||.  ...:|||::.:    |..:...::|..|.||.|...|||||.|.::.|..||.|
Zfish   289 RLVCSVPGNDGTETHFDELRDVFLLQTRDKKNPLIYTVFTTSSSVFQGSAVCLYTMNDIRRAFLG 353

  Fly   352 PFKQQEHSDAAWKTVNTNQRSQFQ----------CGTSSIGHWLESSR------------YQLMD 394
            ||..:|..:..|        ..||          |.:.:.|.: ||::            :.||.
Zfish   354 PFAHKEGPNYQW--------IPFQGKVPYPRPGMCPSKTFGSF-ESTKGFPDNVIQFARHHPLMF 409

  Fly   395 EAVQPIGAEPLYHSKLE-----QFGRLALDIINTKTEQVHVLFVASS-GNHIKKLSV-KYDGDGV 452
            ..|.|:|..||:   |.     .|.::.:|.:|.......|:|:.:. |:.:|.:|| |......
Zfish   410 NPVTPLGGRPLF---LRTGIPYTFTQITVDRVNAADGHYDVMFIGTDVGSVLKVISVPKGSWSNT 471

  Fly   453 QTCLVELWQADDTGTSSLLNMAYLKVSDSLYLGTDLALTRIPAQHCSRH-VSQSSCLNSMDPYCG 516
            :..|.||....|  :||:::|........||:|:|..:.::|...||.: .:.:.|..:.||||.
Zfish   472 ELLLEELHVFKD--SSSIISMQISSKRQQLYVGSDTGVVQVPLHRCSMYGKACAECCLARDPYCA 534

  Fly   517 WN 518
            |:
Zfish   535 WD 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	149/483 (31%)
		PSI	497..546	CDD:279745	8/23 (35%)
		TSP1	556..607	CDD:214559
		TSP1	610..663	CDD:214559
		TSP1	674..725	CDD:214559
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
sema3b	NP_001121818.1	Sema	46..515	CDD:301699	150/486 (31%)
		PSI	514..>550	CDD:214655	8/23 (35%)
		Ig_Semaphorin_classIII	574..664	CDD:143279
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810