DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema5c and sema5a

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	XP_005162676.1	Gene:	sema5a / 561295	ZFINID:	ZDB-GENE-030131-8969	Length:	1078	Species:	Danio rerio

Alignment Length:	1123	Identity:	413/1123 - (36%)
Similarity:	584/1123 - (52%)	Gaps:	141/1123 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLLILSLLTLEGPQPSTGSGYTTKSSVDLLEN-----DSRYISYQDLMSTAKRFYDPETTWYSEM 76
            |:|:.|||.|   .|   .|...:.::..||:     :...||:.|:.....||....|..||::
Zfish    11 LVLLHSLLLL---MP---RGVPCRGAIRALESPCHRAEHPLISHTDIEPWIHRFRAEGTVDYSQL 69

  Fly    77 LFDVARNQVIVGARDTLYRMSF-DLEPLERASWGATPSEIAMCQAKGQSERWCRNYVRVLHSYGE 140
            .||..:|::|||||:.|:|:.. ||..::.|.|.........|.::|:||..|:||:|||...|:
Zfish    70 TFDPGQNELIVGARNHLFRLHLEDLSLIQEAEWHCDEFTKGACFSRGKSEEECQNYIRVLLVNGD 134

  Fly   141 NQLYACGTNAFQPSCSWRQMENLT-VTGVDSGVVKCPFHPQANSTSLLQSNGQLFVGTATDFSGS 204
             :|:.||||||.|.|:.|.:.||| |....||:.:||::|..|||:|:.|:|:|:..||.||||.
Zfish   135 -RLFTCGTNAFTPICTNRTLTNLTEVHDQISGMARCPYNPLHNSTALITSSGELYAATAMDFSGR 198

  Fly   205 DVAILRT--GVESNKRFLRTKQYNNNWLSGAQFVGSFEAGHFVYFLLRESAAEHMSCGKVIYSRV 267
            |.||.|:  |:..    |||.|||:.||:...||.|::.|:|.||..||:|.|| .||:.::||.
Zfish   199 DPAIYRSLGGLPP----LRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEH-DCGRTVFSRA 258

  Fly   268 ARVCKNDVGGGGQLLRDNWTSFLKARLNCSLPGEYPYYFDEIQGMTYAESESILYATFRTSGSSI 332
            |||||||: ||..||.|.||:|:|||||||.|||.|:.::|:||..:.....:||..|.|:.:||
Zfish   259 ARVCKNDI-GGRFLLEDTWTTFMKARLNCSRPGEIPFNYNELQGTFFLPELELLYGIFTTNVNSI 322

  Fly   333 FGSAVCAYNLSSINAAFDGPFKQQEHSDAAWKTVNTNQRSQFQCGTSSIGHWL--------ESSR 389
            ..|||||:|||:|...|.||||.||:|.:||... .|....|||||...|.::        ::.:
Zfish   323 AASAVCAFNLSAITQVFSGPFKYQENSRSAWLPY-PNPNPDFQCGTIDFGSYVNLTERNLQDAQK 386

  Fly   390 YQLMDEAVQPIGAEPLYHSKLEQFGRLALDIINTKTEQVHVLFVASSGNHIKK-LSVKYDGDGVQ 453
            :.||.|.|||:...|.:.....:|..:|:|::..|....|::::|:....||| ||......|
Zfish   387 FILMHEVVQPVVPVPYFMEDNVRFSHVAVDVVQGKDMLYHIIYLATDYGTIKKVLSPLNQTTG-- 449

  Fly   454 TCL---VELWQADDTGTSSLLNMAYLKVSDSLYLGTDLALTRIPAQHCSRHVSQSSCLNSMDPYC 515
            :||   :||:....  ...:.::..|.....|::|....:.:||...|:.|.|:.:|:.:.||||
Zfish   450 SCLLDEIELFPLKK--RQPIRSLLILHSHSELFVGVREQVIKIPLMRCNFHKSREACVGARDPYC 512

  Fly   516 GWNELVERCMPQPQDSSVLQHWHQAPQIT-CPVLNAPIDGGWSTWSPWAVCQQHEQPDS--NCQC 577
            ||:.::::|....:..|:.| |.|:  || |||.|..:||.:..||.|..| .|....|  :|||
Zfish   513 GWDLVLKKCTTLEESVSMSQ-WEQS--ITRCPVRNVTVDGHYGAWSGWKTC-SHSDGGSVGSCQC 573

  Fly   578 RQRSCNNPQPQHGGATCEGISTQVTNCTQHGGWTEWSAWSPCSQTCGIAVKIRRRTCGNPRPAFG 642
            |.|:|::|.||.||..|:|||.:|.||:::|.||.|:||:|||.:|||..::|:|:|.||.|..|
Zfish   574 RTRACDSPSPQCGGQPCQGISVEVANCSRNGAWTPWTAWAPCSTSCGIGFQVRQRSCSNPTPRHG 638

  Fly   643 GRTCVGSEQSEMYCRHLPPCPVAKPQSVDGGWGPWGEWSECSAQCGGGFRMRRRECNDPAPLNGG 707
            ||.|||..:.|.||....|||   |...   |..|..|..|:..||||.:.|||.|.:      |
Zfish   639 GRVCVGQNREERYCNEHLPCP---PHVY---WSAWSPWERCTVPCGGGIQSRRRTCEN------G 691

  Fly   708 MECPGCRLDYEECNMQSCQEVRKLSAWTPWLTVTGSGNSSEPHMERRFRFVCRATSPDPSSVRIG 772
            .|||||..:::.||...|.:::|.:.||||..|..|.|..  |.|:|||:.|:|..|:|..:.:|
Zfish   692 NECPGCSTEFQSCNTLPCPDLKKTTPWTPWTPVNISDNGG--HYEQRFRYTCKARVPEPGLLEVG 754

  Fly   773 LPKEESRNCHADGSCQRQVDHDSADSDA-------------ADWSPCSVSCGGGVQQRHR----- 819
            ..:.|.|.|.:|||.....|.|...|..             ..||.||..|..||:.|.|
Zfish   755 RQRIEMRYCSSDGSTGCSTDGDLLRSGRITGLTVNGGWSVWGPWSQCSRDCSSGVRNRKRTCSNP 819

  Fly   820 ----------GRGSQSRVCNIHACPAEEQLSSNSLDNELEHGEWGCWSEWSACSVTCGLGLRRRT 874
                      |...:.:.||...||.:              |.|.|||.||.||||||.|...||
Zfish   820 KPKYGGITCLGPAQEFQECNTTPCPVD--------------GSWSCWSPWSKCSVTCGGGHYMRT 870

  Fly   875 RRC-----LAGHDRLCQGRALEEQKCEMVPCEDFLGWSAWSEWSSCSSDGIRLRHRRCLVEQPGS 934
            |.|     ..|.| :|.|...||..|.:.||.:  .||.|||||.|.|.|.::|.|.|.|..|..
Zfish   871 RSCNNPPPAYGGD-ICLGLHTEEALCNIQPCPE--SWSDWSEWSPCDSSGSQVRLRHCDVLFPTG 932

  Fly   935 MECRGAEFEKTACVP--NECEETQTASTA---------TLPIVIFVGLLFTVACCLAT---YRFT 985
            .:|.|...|..||:|  |...||..|.::         .:..:|.|||..::..||.|   |.:.
Zfish   933 NQCSGNSSETRACLPISNFIPETSVARSSQEERWCGDFNVFHMIAVGLSSSILGCLVTLLVYTYC 997

  Fly   986 KKRFMLSAEEALNKTTTTTASFDT-YPNQYSSLPTKDYYDQRPKRQSSFRMPAKTSNLGNGNGTL 1049
             :|:...:.:|......:.|..:| ..|..:.|   |.||      |...:.|...|    |..|
Zfish   998 -QRYQQQSHDATVIHPISAAPLNTSISNHINKL---DKYD------SVEAIKAFNKN----NLIL 1048

  Fly  1050 NRNNMHQNNTPKVLAKTY 1067
            ...|.:.|  |::..|||
Zfish  1049 EERNKYFN--PQLAGKTY 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	179/446 (40%)
		PSI	497..546	CDD:279745	17/49 (35%)
		TSP1	556..607	CDD:214559	24/52 (46%)
		TSP1	610..663	CDD:214559	27/52 (52%)
		TSP1	674..725	CDD:214559	20/50 (40%)
		TSP1	802..834	CDD:214559	12/46 (26%)
		TSP1	853..901	CDD:214559	25/52 (48%)
		TSP1	906..953	CDD:214559	22/48 (46%)
sema5a	XP_005162676.1	Sema	58..492	CDD:301699	178/445 (40%)
		PSI	494..541	CDD:279745	17/49 (35%)
		TSP1	552..603	CDD:214559	24/51 (47%)
		TSP1	606..659	CDD:214559	27/52 (52%)
		TSP1	664..710	CDD:214559	20/51 (39%)
		TSP1	792..844	CDD:214559	12/51 (24%)
		TSP1	849..901	CDD:214559	25/52 (48%)
		TSP_1	905..945	CDD:278517	17/39 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	305	1.000	Domainoid score	I1341
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	683	1.000	Inparanoid score	I680
OMA	1	1.010	-	-		QHG47498
OrthoDB	1	1.010	-	-		D41799at33208
OrthoFinder	1	1.000	-	-		FOG0003495
OrthoInspector	1	1.000	-	-		otm25668
orthoMCL	1	0.900	-	-		OOG6_106097
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9633
SonicParanoid	1	1.000	-	-		X2388
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.010