DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema5c and sema4bb

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	XP_005168979.2	Gene:	sema4bb / 561146	ZFINID:	ZDB-GENE-120503-1	Length:	849	Species:	Danio rerio

Alignment Length:	821	Identity:	195/821 - (23%)
Similarity:	336/821 - (40%)	Gaps:	170/821 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 YSEMLFDVARNQVIVGARDTLYRMSFD---LEPLERA-SWGATPSEIAMCQAKGQSERW-CRNYV 132
            ||.:|.....|::.||||:.::.:|.|   :..|::. :|....::...|..||:..:. |.||:
Zfish    70 YSALLLSPDENKIYVGARENIFSLSLDNISVTHLQKTLTWSTPETKRGECIFKGKDPQTDCFNYI 134

  Fly   133 RVLHSYGENQLYACGTNAFQPSCSWRQMENLTVTG-------VDSGVVKCPFHPQANSTSLLQSN 190
            ::|.......|:.|||.||.|.|::..:.:.::..       ::.|..:|||:|:..||: :..:
Zfish   135 KILLRLNSTHLFVCGTYAFSPICTYINISSFSLEADEKGEPIMEDGRGRCPFNPEYRSTA-ITVD 198

  Fly   191 GQLFVGTATDFSGSDVAILR---TGVESNKRFLRTKQYNNNWLSGAQFVGSFEAGHF-------- 244
            |:|:..|.::|.|::.:|.|   :|..     |:|:. :.|||....||||   .|.
Zfish   199 GELYTATVSNFQGNEPSIYRSLGSGTP-----LKTEN-SLNWLQDPAFVGS---AHITGSDSERN 254

  Fly   245 ---VYFLLRESAAEHMSCGKVIYSRVARVCKNDVGGGGQLLRDNWTSFLKARLNCSLPGE-YPYY 305
               :||...|:..|.......|.||:|||||.| .||.::|:..||:||||:|.||||.: :|
Zfish   255 DDQIYFFFSETGKEFDFFDNTIVSRIARVCKED-QGGERVLQKKWTTFLKAQLLCSLPDDGFP-- 316

  Fly   306 FDEIQGM----TYAESESILYATFRTSGS-SIFG-SAVCAYNLSSINAAFDGPFKQQEHSDAAWK 364
            |:.||.:    ...:..::|||.|.:..| .:.| ||||.:::..::.||.|.:|:.......|.
Zfish   317 FNIIQDVYVLPAKRKKNTLLYAVFASQWSKGLAGSSAVCVFSMDQVDQAFTGRYKEVNRETQQWY 381

  Fly   365 TVN------------TNQRSQFQCGTS-----SIGHWLESSRYQLMDEAVQPIGAEPLYHSKLEQ 412
            |..            ||...|....:|     .:.::::.  :.|||   :|:.::|:..:....
Zfish   382 TYTQSVPEPRPGMCITNASRQLGIDSSLDMPDKVLNFVKD--HFLMD---RPVRSQPVLFTHTVH 441

  Fly   413 FGRLALDIINTKTEQVHVLFVASSGNHIKK-LSVKYDGDGVQTCLVELWQADDTGTSSLLNMAYL 476
            :.::|:..:........|:|:.::...::| ::|.    |:...:.|:....:......:.:...
Zfish   442 YTQIAVHHVKGLHRAYDVMFIGTADGRLQKAVNVA----GMMHIIEEIQLFSEQQPVQQIELDSA 502

  Fly   477 KVSDSLYLGTDLALTRIPAQHCSRHVSQSSCLNSMDPYCGW--NELVERCMPQPQDSSVLQHWHQ 539
            |  ..|::.:...:.::|..:||.|.:...|:.:.||||.|  ....:..:..||:     .|.|
Zfish   503 K--GLLFVSSHSGIVQLPVANCSFHNNCGECVLARDPYCAWTGTHCTDVTLVPPQN-----QWQQ 560

  Fly   540 ----APQITCPVLNAPIDGGWS------TWSPWAVCQQHEQPDSNCQ---CRQRSCN-------N 584
                |....|......:|.|.|      |.|..:.|:....|.:..|   |..||.:       .
Zfish   561 DIEEADTSKCNSTMLRVDSGSSVSPRSFTNSETSDCELIIIPANTLQLLPCNLRSNHAHRKWLYK 625

  Fly   585 PQPQH-------GGATCEGI--STQVTNCTQHGGWTE----WSAWS-------PCSQTCGIAVKI 629
            |...|       ||....|.  |.:|.:|     |:|    |...:       |.|:|   ..||
Zfish   626 PNVSHFLFPSADGGLVVSGRAGSDEVFSC-----WSEERGFWQLLANYCVKAEPLSET---TTKI 682

  Fly   630 RRRTCGNPRPAFGGRTCVGSEQSEMY----------------CRHLPPCPVAKPQSVDGGWGPWG 678
            .|:..  |.......:.:.||:||.:                |..|..|.::...||  .:...|
Zfish   683 GRKEA--PFLIQSIASDILSEESEAHSAQHRIKTYGTELAVVCVLLAVCVLSFGLSV--VYRHRG 743

  Fly   679 EWSEC--SAQCGGGFRMRRRECNDPAPLNGGM--ECPGCRLDYEECNMQSCQEV--------RKL 731
            ...|.  ..:..||.:.......:..|||.|.  ..|.....|:... ::|..:        .:.
Zfish   744 RMKEVLRGGEQAGGAQKSTVHPGESLPLNAGAPPTSPSEHKSYQTLE-ENCSYIIAPAETNTPQK 807

  Fly   732 SAWTPWLTVTGSGNSSEPHMERRFRFVCRATSPDPSSVRIG 772
            |..|..|..|......|.|:|      ....||.| .||:|
Zfish   808 SEETQILKPTPQNGYKESHVE------VSDISPRP-RVRLG 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	118/473 (25%)
		PSI	497..546	CDD:279745	14/54 (26%)
		TSP1	556..607	CDD:214559	17/75 (23%)
		TSP1	610..663	CDD:214559	16/79 (20%)
		TSP1	674..725	CDD:214559	10/54 (19%)
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
sema4bb	XP_005168979.2	Sema_4B	61..520	CDD:200518	118/473 (25%)
		PSI	521..570	CDD:307546	14/53 (26%)
		Ig	596..670	CDD:325142	17/78 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41799at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820