DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema5c and si:dkey-49n23.1

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	XP_021329223.1	Gene:	si:dkey-49n23.1 / 558742	ZFINID:	ZDB-GENE-050208-762	Length:	758	Species:	Danio rerio

Alignment Length:	808	Identity:	216/808 - (26%)
Similarity:	345/808 - (42%)	Gaps:	175/808 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LWLLLILSLLTLEGPQPSTGSGYTTKSSVDLLENDSRYISYQDLMSTAKRFYD-PETTWYSEMLF 78
            ||...:.|||.|.....:.|:..|.:..:...|..||        :.:..|:| .|...|..:|.
Zfish     6 LWRTGLFSLLVLSLLHCNAGNQNTPRLQLTHTELRSR--------NGSAVFWDGGEGGAYQALLL 62

  Fly    79 DVARNQVIVGARDTLYRMSFD--LEPLERASWGATPSEIAMCQAKGQS-ERWCRNYVRVLHSYGE 140
            |..|..::||.||.:|.::.|  .:|..:..|.|....|..|:..|:: ...|.||||:|..:.:
Zfish    63 DEDRGWLLVGGRDHIYMLNSDSLTQPSRKIHWPAGQEHIERCKYAGKNLSMDCANYVRLLQPFNK 127

  Fly   141 NQLYACGTNAFQPSCSWRQM---------ENLTVTGVDSGVVKCPFHPQANSTSLLQSNGQLFVG 196
            ..:|.|||.||.|.|::..:         :.|:..| :||..||||.||...|:.| ::|:|:.|
Zfish   128 THVYVCGTGAFHPQCTYIDLGHNLEKPTFQLLSHVG-ESGRGKCPFSPQEPFTAHL-TDGELYAG 190

  Fly   197 TATDFSGSDVAILRTGVES-NKRFLRTKQYNNNWLSGAQFVGSFEA-------GHFVYFLLRESA 253
            ||.||.|::.||.||.|.| |:.::||:.|.::||:..:||||:..       ...|||..:|:|
Zfish   191 TAVDFMGTNAAIFRTSVHSNNQHYIRTEAYQDHWLNEPEFVGSYSIPDTHSLDDDKVYFFFKETA 255

  Fly   254 AEHMSCGKVIYSRVARVCKNDVGGGGQLLRDNWTSFLKARLNCSLPGE--YPYYFDEIQGMTYAE 316
            .|.....|.||||||||||||:||...|: :.|::||||||.|::||.  ...:|||::.:...|
Zfish   256 VESNQLDKRIYSRVARVCKNDIGGKRSLI-NRWSTFLKARLVCTVPGPGGMDTHFDELEDIFLLE 319

  Fly   317 SES----ILYATFRTSGSSIFGSAVCAYNLSSINAAFDGPFKQQEHSDAAWKTVNTNQRSQFQ-- 375
            ::.    ::|..|.||.|...|||||.|:::||.|||:|||..:|..|..|        .:::
Zfish   320 TKDPQNPVIYGVFSTSSSVFRGSAVCVYSMASIRAAFNGPFAHKESPDYRW--------MEYKGK 376

  Fly   376 --------CGTSSIGHWLESSR------------YQLMDEAVQPIGAEPLYHSKLE---QFGRLA 417
                    |.:.:.....:|:|            :|||.|.|.||...|:: :::.   :..:|.
Zfish   377 IPYPRPGTCPSETYDALYKSTRDFPDDVVSFMRAHQLMWEPVVPIHRRPVF-TRINTPYRLKKLV 440

  Fly   418 LDIINTKTEQVHVLFVAS-SGNHIKKLSVKYDGDGVQTCLVELWQADDTGTSSLLNMAYLKVSDS 481
            :|.::.:..|..||.:.: .|..:|.:||..:...::..::|......|.| .:|:|........
Zfish   441 VDRVDAEDGQYDVLHLGTDDGRVLKVVSVPKENWEIEEIILEELNVFKTQT-PILSMELSTKRQV 504

  Fly   482 LYLGTDLALTRIPAQHCSRHVSQS-SCLNSMDPYCGWNELVERCMPQPQDSSVLQHWHQAPQITC 545
            |::.:|..:.::|.|.|..:.... .|..:.||||.|:           .||...::   |....
Zfish   505 LFISSDENVVQLPVQRCELYGKACVDCCLARDPYCAWD-----------GSSCTNYF---PSNKR 555

  Fly   546 PVLNAPIDGGWSTWSPWAVCQQHEQPDSNCQCRQ----------RSC--NNP--------QPQHG 590
            ......:..|    .||:.||.......|.:.:.          ..|  |:|        ||.|.
Zfish   556 RARRQDVRYG----DPWSQCQDMRDGSENAELKTVYGVETNSTFLECVSNSPQATIKWIFQPNHS 616

  Fly   591 GATCE-------------GISTQVTNCTQHGGWTEWSAWSPCSQTCG-----IAVKIRRRTCGNP 637
            ..:.|             |:..|....|..|.:...:.....|:|..     :..:.:.....|.
Zfish   617 QNSKELVPGEENLLHMQRGLLLQQITSTNAGLYLCMAFEHSFSRTLARYELHVIPQNQMSRAQNN 681

  Fly   638 RPAFGGRTC----------VGSEQSEMYCRHLPPCPVAKPQSVDGGWGPWG------------EW 680
            .|.....:.          ||...::.||.||                 |.            :|
Zfish   682 LPGNHATSLRSYKELHLMGVGGLTADEYCEHL-----------------WYREKRRQHKHRTLKW 729

  Fly   681 SECSAQCGGGFRMRRRECNDP-APLNGG 707
            .:.|.....  |:||:  |.| .||:||
Zfish   730 KQVSENRKA--RVRRQ--NPPDEPLDGG 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	155/483 (32%)
		PSI	497..546	CDD:279745	10/49 (20%)
		TSP1	556..607	CDD:214559	15/83 (18%)
		TSP1	610..663	CDD:214559	10/67 (15%)
		TSP1	674..725	CDD:214559	12/47 (26%)
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
si:dkey-49n23.1	XP_021329223.1	Sema_3	48..521	CDD:200500	156/485 (32%)
		PSI	520..557	CDD:214655	10/50 (20%)
		Ig_Semaphorin_classIII	581..672	CDD:143279	13/90 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910