DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema5c and Sema4g

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	NP_001101996.1	Gene:	Sema4g / 361764	RGDID:	1310436	Length:	837	Species:	Rattus norvegicus

Alignment Length:	679	Identity:	171/679 - (25%)
Similarity:	270/679 - (39%)	Gaps:	153/679 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MFSQLWLLLILSLLTLEGPQPSTGSGYTTKSSVDLLENDSRYISYQDLMSTAKRFYDPETTWYSE 75
            |:.:||.||...|.....|.||     ..:.|.:|.......|||::|  :..|.:..:...||.
  Rat     1 MWGRLWPLLFSFLTATAVPGPS-----LRRPSRELDATPRMTISYEEL--SWIRHFKGQAQNYST 58

  Fly    76 MLFDVARNQVIVGARDTLYRMSF-DL--EPLERASWGATPSEIAMCQAKGQSERW-CRNYVRVLH 136
            :|.:.|..:::||||..|:.:|. |:  ...:...|.|:|...:.|..||::.:. |.|:||.|.
  Rat    59 LLLEEASQRLLVGARGALFSLSARDIGDGTHKEIHWEASPEMQSKCHQKGKNNQTECFNHVRFLQ 123

  Fly   137 SYGENQLYACGTNAFQPSCSWRQMENLTV-TGVDSGVVKCPFHPQANSTSLLQSNGQLFVGTATD 200
            ....:..|||||:||||.|:....|...: |..:.|..|||:.|....|.|: .:|.|:..|..:
  Rat   124 RLNASHFYACGTHAFQPLCAAIDAEAFILPTSFEEGKEKCPYDPARGFTGLI-IDGGLYTATRYE 187

  Fly   201 F-SGSDVAILRTGVESNKRFLRTKQYNNNWLSGAQFVGSF------------EAGHFVYFLLRES 252
            | |..|:...|     :...|||::...:||:.|:||.|.            :...:.:|:.||.
  Rat   188 FRSIPDIRRSR-----HPHSLRTEEAPMHWLNDAEFVFSVLVRESKTSVVGDDDKIYYFFMEREE 247

  Fly   253 AAEHMSCGKVIY--SRVARVCKNDVGGGGQLLRDNWTSFLKARLNCSLPGEYPYYFDEIQGMTYA 315
            .:...:..:..:  :|||||||.|: ||.::|:..|||||||||.|.:|     .::.::|:...
  Rat   248 GSSSFTQSRSSHRVARVARVCKGDL-GGKKILQKKWTSFLKARLICHIP-----QYETLRGVCSL 306

  Fly   316 E----SESILYATF--RTSGSSIFGSAVCAYNLSSINAAFDGPFKQQEHSDAAWKTVNTNQRSQF 374
            :    |.:..||.|  .|...::..||:|.|:|:.|.|.|.|||.:.:.....|        .::
  Rat   307 DADTSSHTHFYAVFTLTTQWKTLEASAICRYDLAEIQAVFTGPFMEYQDGARRW--------GRY 363

  Fly   375 QCGT------SSIGHWLESSRYQ-----------------LMDEAVQPIGAEPLYHSKLEQFGRL 416
            :.|.      |.|...|.|..|.                 ||...|.|....||...:..::..|
  Rat   364 EGGVPEPRPGSCITDSLRSRGYNSSQDLPSLVLDFVKLHPLMARPVVPTRGRPLLLKRNVRYTHL 428

  Fly   417 A-------------LDIINTKTEQVHVLFVASSGNH-IKKLSVKYDGDGVQTCLVELWQADDTGT 467
            .             |..:.|....:|...|..||.| |:::.|..:...|.
  Rat   429 TGTHVSIPAGPTYDLLFLGTADGWIHKAVVLGSGMHIIEEIQVFRESQSVD-------------- 479

  Fly   468 SSLLNMAYLKVSDSLYLGTDLALTRIPAQHCSRHVSQSSCLNSMDPYCGWNELVERCMPQPQDSS 532
                |:....:..|||:|....:.:.|...|||:.|...|:.:.||||||:.....||
  Rat   480 ----NLVISPMQHSLYVGAASGVIQFPLSSCSRYRSCYDCILARDPYCGWDSSTHACM------- 533

  Fly   533 VLQHWHQAPQITCPVLNAPIDGGWSTWSPWAVCQQHEQPDSNCQCRQRSCNNPQPQHGGATCEGI 597
                      :...:.|..           |:.|..|:.:..|: ..|....|.|....:...|.
  Rat   534 ----------VATTIANRT-----------ALIQDIERGNRGCE-GSRDAGPPPPFKTRSVLRGD 576

  Fly   598 STQVTNCTQHGGWTEWSAWSPCSQTCGIA 626
            ...:                ||.|...:|
  Rat   577 DVLL----------------PCDQPSNLA 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	129/493 (26%)
		PSI	497..546	CDD:279745	13/48 (27%)
		TSP1	556..607	CDD:214559	8/50 (16%)
		TSP1	610..663	CDD:214559	4/17 (24%)
		TSP1	674..725	CDD:214559
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
Sema4g	NP_001101996.1	Sema	47..504	CDD:301699	130/494 (26%)
		PSI	505..>533	CDD:279745	11/27 (41%)
		Ig_Sema4B_like	565..648	CDD:143280	6/41 (15%)
		IG_like	571..648	CDD:214653	5/35 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810