DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema5c and Sema1a

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster

Alignment Length:	584	Identity:	190/584 - (32%)
Similarity:	289/584 - (49%)	Gaps:	90/584 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KLPKMFSQLWL--LLILSLLTLEGPQPSTGSGYTTKSSVDLLEND-SRYISYQDLMSTAKRFYDP 68
            ||.|.:...|:  .|:|::|.: |.|.:.......|..|:|...| .:::..:.::...|
  Fly    40 KLSKFYGYGWMQVFLLLTVLVI-GNQSAWQENIRPKLYVELGPEDVLKFVGNESVVDHFK----- 98

  Fly    69 ETTWYSEMLFDVARNQVIVGARDTLYRMSF-DLEPLERASWGATPSEIAMCQAKGQSERWCRNYV 132
                    |.....|.:::|||:|::.:|. ||...:|..|.:...:..||..||:.|..|:||:
  Fly    99 --------LVTKDGNSLLIGARNTVFNLSIHDLVEQQRLVWTSPEDDTKMCLVKGKDEEACQNYI 155

  Fly   133 RVLHSYGENQLYACGTNAFQPSCSWRQM--ENLTVTGVDSGVVKCPFHPQANSTSLLQSNGQLFV 195
            |::......:|:.||||:|:|.|:...:  .|.|:....:|...||:.|:.||||:|..| :|:.
  Fly   156 RIMVVPSPGRLFVCGTNSFRPMCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADN-ELYS 219

  Fly   196 GTATDFSGSDVAILRTGVESNKRFLRTKQYNNNWLSGAQFVGSFEAGHFVYFLLRESAAEHMSCG 260
            ||..||||||..|.|..       |:|:||::..|:...||.||..|.||||..||:|.|.::||
  Fly   220 GTVADFSGSDPIIYREP-------LQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETAVEFINCG 277

  Fly   261 KVIYSRVARVCKNDVGGGGQLLRDNWTSFLKARLNCSLPGEYPYYFDEIQ-------GMTYAESE 318
            |.||||||||||.|.||..: .|:.||||||:|||||:||:||:||:|||       |...:.|.
  Fly   278 KAIYSRVARVCKWDKGGPHR-FRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSS 341

  Fly   319 SILYATFRTSGSSIFGSAVCAYNLSSINAAFDGPFKQQEHSDAAWKTVNTNQRSQFQCGTSSIGH 383
            .::|..|.|..:||.||||||:.|..|...|:|.||:|...::.|..||..:....:.|:..
  Fly   342 KLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSCH--- 403

  Fly   384 WLESSR------------YQLMDEAVQPIGAEPLY--HSKLEQFGRLALDI-INTKTEQVH-VLF 432
              ..||            :.||||.|....::|:.  .|.:.:|.::|:|. |.|...:.: |:|
  Fly   404 --NDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIF 466

  Fly   433 VASS-GNHIKKLSVKY--DGDGVQTCLVELWQADDTGTSS--------LLNMAYLKVSDSLY--- 483
            |.:. |..||.::.:.  ..|.|.:.::|   ..|..|.|        :..|.|.:..|..|
  Fly   467 VGTDHGKIIKSVNAESADSADKVTSVVIE---EIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDG 528

  Fly   484 ---LGTDLALTRIPAQHC--SRHVSQSSCLNSMDPYCGWNELVERCMPQPQDSSVLQHWHQAPQ 542
               :.||..:..|....|  .:..|.|.|:...||||.|:::..:|..           |.||:
  Fly   529 KLIIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRS-----------HGAPR 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	163/473 (34%)
		PSI	497..546	CDD:279745	13/48 (27%)
		TSP1	556..607	CDD:214559
		TSP1	610..663	CDD:214559
		TSP1	674..725	CDD:214559
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	164/484 (34%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	11/44 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910