DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema5c and sema7a

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	NP_001315437.1	Gene:	sema7a / 324910	ZFINID:	ZDB-GENE-030131-3633	Length:	640	Species:	Danio rerio

Alignment Length:	652	Identity:	162/652 - (24%)
Similarity:	266/652 - (40%)	Gaps:	139/652 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 LENDSRYISYQDLMSTAKRFYDPETTWYSEMLFDVARNQVIVGARDTLYRMSFDLEPLERASWGA 110
            |:.|:..::|....|....|::..    |:.||        ||..:.:  :.||::..|......
Zfish    38 LKQDNAPLNYNTNYSHTVLFHEEG----SKSLF--------VGGSNIV--LHFDVDSYEILENFT 88

  Fly   111 TPSEIAMCQAKGQSERWCRNYVRVLHSYGENQLYACGTNAFQPSCSW----RQMENLTVTGVDSG 171
            ..:.:..|   |:|.  |.|.|.|:.:: :|..:.||||..:|.| |    |:..:..|..|: |
Zfish    89 LNANLPRC---GESS--CENVVTVIETF-QNCKFVCGTNGEEPQC-WELYPRESNHSVVKSVE-G 145

  Fly   172 VVKCPFHPQANSTSLLQSNGQLFVGTATDFSGSDVAILRTGVESNKRFLRTKQYNNNWLSGAQFV 236
            ....|...:.||.||: ::|.|:.....   .||..:|:...::.||.  ....::.|:|...|:
Zfish   146 TGISPHSSEQNSLSLV-ADGDLYAAAPL---YSDGTLLQFRRKAGKRI--NVWMHDQWVSEPTFI 204

  Fly   237 GSFEA-------GHFVYFLLRESAAEHMSCGKVIYSRVARVCKNDVGGGGQLLRDNWTSFLKARL 294
            .||.|       ...:|.|.||..::.........||||||||.|.||..|.|::.|||||||||
Zfish   205 SSFLAKRKNDSLNEKIYVLFREKNSDTSPEADPWISRVARVCKIDEGGSKQFLQNIWTSFLKARL 269

  Fly   295 NCSLPGEYPYYFDEIQG--MTYAES--ESILYATFRTSGSSIFGSAVCAYNLSSINAAFDGPFKQ 355
            .|.:|.| ..||:.:|.  :.:||.  :|::||.|.:|.:|   :|||.|:|:.::..|
Zfish   270 VCGIPKE-SLYFNRLQDVFVQHAEDWRDSLVYALFSSSWNS---TAVCIYSLADLDDIF------ 324

  Fly   356 QEHSDAAWKTVNTNQRSQFQCGTSSI-----GHWLESSR------------YQLMDEAVQPIGAE 403
                          ::|.::..:.:|     |..:|:|.            |..|.:.:.||..:
Zfish   325 --------------EKSNYKGFSEAIPNPRPGKCVENSNSLPIPTLKIIKDYPEMKDWIHPIQKD 375

  Fly   404 PLYHSKLEQFGRLALDIINTKTEQVH-VLFVASSGNHIKKL----SVKYDGDGVQTCLVELWQAD 463
            ..:.:..:.|.::.:|.|....|.|: ||.:|:....|.|:    |..:.......|
Zfish   376 TPFFTSSKNFTKIVVDQIRALDENVYNVLLLATDDGMIFKILQHGSKPFIISETHLC-------- 432

  Fly   464 DTGTSSLLNMAYLKVSDSLYLGTDLALTRIPAQHCSRH-VSQSSCLNSMDPYCGWNELVERCMPQ 527
             .|.:.:.:|........|::|....::.:..|.|..: .|...|:.|.||||.|:|  :.|..|
Zfish   433 -NGCAPIQSMKLDSKKRKLFVGYPGQMSVLELQRCQDYGASCEECVLSRDPYCAWSE--KGCTSQ 494

  Fly   528 PQDSSVLQHWHQAPQITCPVLNAPIDGGWSTWSPWAVCQQHEQPDSNCQCRQRSCNNPQPQHGGA 592
            .:..  :|:               |..|..|    .||............:|.|....:.||..|
Zfish   495 TRGG--IQN---------------ISDGNVT----KVCDHKSVGRVRRDAQQSSTAPSRIQHTVA 538

  Fly   593 T-------CEGISTQVTNCTQHGGWTEWSAWSPCSQT-CGIAVKIRRRTCGNPRPAFGGRTCVGS 649
            |       |...|...:...:|||.:     :||.|| ....:.|...|..|    :|..:||..
Zfish   539 TDVPFYLSCPVDSHHASYRWEHGGKS-----NPCQQTQSEYLLLIPAMTAEN----YGNYSCVSQ 594

  Fly   650 EQ 651
            |:
Zfish   595 ER 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	117/467 (25%)
		PSI	497..546	CDD:279745	13/49 (27%)
		TSP1	556..607	CDD:214559	11/57 (19%)
		TSP1	610..663	CDD:214559	11/43 (26%)
		TSP1	674..725	CDD:214559
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
sema7a	NP_001315437.1	Sema	50..463	CDD:301699	118/473 (25%)
		PSI	465..505	CDD:214655	14/58 (24%)
		Ig	534..607	CDD:299845	20/72 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900