DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sema5c and Sema4a

DIOPT Version :10

Sequence 1:NP_611293.3 Gene:Sema5c / 37066 FlyBaseID:FBgn0284221 Length:1093 Species:Drosophila melanogaster
Sequence 2:NP_001012078.2 Gene:Sema4a / 310630 RGDID:1304636 Length:762 Species:Rattus norvegicus


Alignment Length:669 Identity:184/669 - (27%)
Similarity:290/669 - (43%) Gaps:130/669 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 LILKLPKMFSQLWLLL------ILSLLTL--------EGPQP----STGSGYTTKSSVDLLENDS 50
            :.:.||.:....|.||      :..||:|        :||.|    ..|.|:             
  Rat     1 MTMALPSLGQDPWSLLSVFFFQLFLLLSLPPASGTGGQGPVPRVKYHAGDGH------------- 52

  Fly    51 RYISYQDLMSTAKRFYDPETTWYSEMLFDVARNQVIVGARDTLYRMSFDLEPLER----ASWGAT 111
            |.:|:         |.......:..:|.....|.:.||||:.:..::.:...:.|    ..|.|:
  Rat    53 RALSF---------FQQKGLRDFDTLLLSGDGNTLYVGAREAILALNIENPGIPRLRNMIPWPAS 108

  Fly   112 PSEIAMCQAKGQS-ERWCRNYVRVLHSYGENQLYACGTNAFQPSCSWRQMEN-----LTVTGVDS 170
            ..:...|..|.:| |..|.|::|||.||....||||||.||.|:|::.::::     :....|..
  Rat   109 EKKKNECAFKKKSNETQCFNFIRVLVSYNATHLYACGTFAFSPACTFIELQDSFLLPILKDKVTD 173

  Fly   171 GVVKCPFHPQANSTSLLQSNGQLFVGTATDFSGSDVAILRT----GVESNKRFLRTKQYNNNWL- 230
            |..:.||.|....|::| .:|.|:.||..:|.||:..::||    .|.....|||       || 
  Rat   174 GKGQSPFDPAHKHTAVL-VDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDIFLR-------WLH 230

  Fly   231 SGAQFVGSFEAGHFVYFLLRESAAEHMSCGKVIYSRVARVCKNDVGGGGQLLRDNWTSFLKARLN 295
            ..|.||.:..:...|||...|:|:|.....::..||||:|||||| ||.:||:..||:||||:|.
  Rat   231 PDASFVAAIPSTQVVYFFFEETASEFDFFEELYTSRVAQVCKNDV-GGEKLLQKKWTTFLKAQLL 294

  Fly   296 CSLPGEYPYYFDEIQGMTYAESESI--LYATFRTSGSSIFG---SAVCAYNLSSINAAFDGPFKQ 355
            |:.||:.|:.......:..|:|.|:  :||.| ||...:.|   |||||::|:.|...|.|.:|:
  Rat   295 CAQPGQLPFNIIRHAVLLPADSPSVPRIYAVF-TSQWQVGGTRSSAVCAFSLTDIERVFKGKYKE 358

  Fly   356 QEHSDAAWKTV---NTNQRSQFQCGTSSIGHWLESS-----RYQLMDEAVQPIGAEPLYHSKLEQ 412
            .....:.|.|.   ..|.|.    |:.|:|...:.:     .:.||||.|  :||..|..|.:| 
  Rat   359 LNKETSRWTTYRGSEVNPRP----GSCSMGPSSDKALTFMKDHFLMDEHV--VGAPLLVKSGVE- 416

  Fly   413 FGRLALDIINTKTEQVH-VLFVASSGNHIKKLSVKYDGDGVQTCLVELWQADDTGTSSLLNMAYL 476
            :.:||::.........| ||::.:|...:.|..|..:....   |||..|. ...:..:.|:...
  Rat   417 YTQLAVETAQGLDGSSHVVLYLGTSTGSLHKAVVPQNSSAY---LVEEIQL-SPNSEPVQNLQLA 477

  Fly   477 KVSDSLYLGTDLALTRIPAQHCSRHVSQSSCLNSMDPYCGWNELVERCMPQPQDSSVLQ----HW 537
            ....:::.|....:.|:|..:||.:.|...|:.:.||:|.|:       |:.:..|:|.    .|
  Rat   478 PTQGAVFAGFSEGIWRVPRANCSVYKSCVDCVLARDPHCAWD-------PESRLCSLLSGSPLTW 535

  Fly   538 HQ-----APQITC---PVLNAPIDGGWSTWSPWAVCQQHEQPDSNCQCRQRSCNNPQPQ------ 588
            .|     .|:..|   |:..:|....    ||..:.:....|:|..:.       |.||      
  Rat   536 KQDMERGNPEWACARGPMARSPRRQS----SPQLIKEVLTVPNSILEL-------PCPQLSALAS 589

  Fly   589 ----HGGATCEGISTQVTN 603
                ||.|.....|:.|.|
  Rat   590 YHWSHGKAKIPEASSTVYN 608

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema5cNP_611293.3 Sema_5C 65..496 CDD:200526 139/459 (30%)
PSI 497..546 CDD:396154 15/60 (25%)
TSP1 556..607 CDD:214559 13/58 (22%)
TSP1 610..663 CDD:214559
TSP1 674..725 CDD:214559
TSP1 802..834 CDD:214559
TSP1 853..901 CDD:214559
TSP1 906..953 CDD:214559
Sema4aNP_001012078.2 Sema 57..497 CDD:472829 139/469 (30%)
PSI 498..542 CDD:214655 13/50 (26%)
Ig 572..639 CDD:472250 11/44 (25%)
Ig strand B 577..581 CDD:409353 0/10 (0%)
Ig strand C 589..593 CDD:409353 0/3 (0%)
Ig strand E 608..612 CDD:409353 1/1 (100%)
Ig strand F 622..627 CDD:409353
Blue background indicates that the domain is not in the aligned region.

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