DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema5c and Sema4d

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	NP_001164034.1	Gene:	Sema4d / 306790	RGDID:	1310554	Length:	862	Species:	Rattus norvegicus

Alignment Length:	697	Identity:	177/697 - (25%)
Similarity:	285/697 - (40%)	Gaps:	160/697 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 RFYDPETTWYSEMLFDVARNQVIVGARDTLYRM-SFDL-EPLERASWGATPSEIAMCQAKGQSER 126
            :|::|....||.:|....::.:.||||:.::.: :.|: |......|..:..:.:.|..||:|::
  Rat    41 KFHEPGIFNYSSLLMSEDKDTLYVGAREAVFAVNALDISEKQHEVYWKVSEDKKSKCAEKGKSKQ 105

  Fly   127 W-CRNYVRVLHSYGENQLYACGTNAFQPSCSWRQMENLTVTG-VDSGVVKCPFHPQANSTSLLQS 189
            . |.||:|||.......||.||||||||:|....:.:....| .:.|..:|||.|..:.||:: .
  Rat   106 TECLNYIRVLQPLSSTSLYVCGTNAFQPTCDHLNLTSFKFLGKSEDGKGRCPFDPAHSYTSVM-V 169

  Fly   190 NGQLFVGTATDFSGSDVAILRTGVESNKRFLRTKQYNNNWLSGAQFV----------GSFEAGHF 244
            .|:|:.||:.:|.||:..|.|....|.   ||| :|...||:...||          |:......
  Rat   170 GGELYSGTSYNFLGSEPIISRNSSHSP---LRT-EYAIPWLNEPSFVFADVIHKSPDGTEAEDDK 230

  Fly   245 VYFLLRESAAEHMSCGKVIYSRVARVCKNDVGGGGQLLRDNWTSFLKARLNCSLPGEYPYYFDEI 309
            |||...|.:.|:....|::..|||||||.| .||.:.|:..|||||||||.||.| :....|:.:
  Rat   231 VYFFFTEVSVEYEFVFKLMIPRVARVCKGD-QGGLRTLQKKWTSFLKARLICSRP-DSGLVFNIL 293

  Fly   310 QGMTYAES----ESILYATFRTSGSSIFGSAVCAYNLSSINAAFD-GPFKQQ---EHSDAAWKTV 366
            |.:....:    |.:.||.|....:::..||||||.||::.|.|. |.:.|.   |.|...|...
  Rat   294 QDVFVLRAPGLKEPVFYAVFTPQLNNVGLSAVCAYTLSTVEAVFSRGKYMQSATVEQSHTKWVRY 358

  Fly   367 N-----------TNQRSQFQCGTSSIGHWLESSRYQ------LMDEAVQPIGAEPLYHSKLEQFG 414
            |           .:..::....|||:.  |.....|      |||::|.||...|....|...:.
  Rat   359 NGPVPTPRPGACIDSEARAANYTSSLN--LPDKTLQFVKDHPLMDDSVTPIDNRPKLIKKDVNYT 421

  Fly   415 RLALD-------------IINTKTEQVHVLFVASSGNHIKKLSVKYDGDGVQTCLVELWQADDTG 466
            ::.:|             .::|....:|...:.:...|:.:.:             :|:|..:..
  Rat   422 QIVVDRTQALDGTFYDVMFLSTDRGALHKAVILAKEVHVVEET-------------QLFQDFEPV 473

  Fly   467 TSSLLNMAYLKVSDSLYLGTDLALTRIPAQHCSRHVSQSSCLNSMDPYCGWNELVERCMPQPQDS 531
            .|.||:..  |....:|.|::..:.:.|...|.:|.|...|:.:.||||.|:..::.|:.
  Rat   474 LSLLLSSK--KGRKFVYAGSNSGVVQAPLAFCGKHSSCEDCVLARDPYCAWSPAIKACVT----- 531

  Fly   532 SVLQHWHQAPQITCPVLNAPIDGGWSTWSPWAVCQQHEQPDSNCQCRQRSCNNPQPQHGGATCEG 596
                 .|||            :|....|     .|......|:|..:.:...:   ||
  Rat   532 -----LHQA------------EGSSRGW-----IQDMSGDTSSCLDKSKESFH---QH------- 564

  Fly   597 ISTQVTNCTQHGGWTEWSAWSPCSQTCGIAVKIRRRTCG-----NPRPAFGGR------------ 644
                   ..:|||..|..    |.|...:|..:.:...|     :|:..|.||
  Rat   565 -------FFKHGGTAELK----CFQKSNLARVVWKFQNGELKAVSPKYGFVGRKHLLIFNLSDGD 618

  Fly   645 ----TCVGSEQ------SEMYCRH---------LPPCPVAKPQSVDG 672
                .|:..|:      |::..:|         :||.|.::....:|
  Rat   619 SGVYQCLSEERVRNKTVSQLLAKHILEVKMVARIPPSPTSQTAQTEG 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	137/482 (28%)
		PSI	497..546	CDD:279745	13/48 (27%)
		TSP1	556..607	CDD:214559	6/50 (12%)
		TSP1	610..663	CDD:214559	15/88 (17%)
		TSP1	674..725	CDD:214559
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
Sema4d	NP_001164034.1	Sema_4D	31..501	CDD:200520	137/483 (28%)
		PSI	503..548	CDD:396154	16/71 (23%)
		Ig	563..646	CDD:416386	18/100 (18%)
		Ig strand B	569..577	CDD:409353	3/11 (27%)
		Ig strand C	583..589	CDD:409353	1/5 (20%)
		Ig strand C'	591..594	CDD:409353	1/2 (50%)
		Ig strand D	600..604	CDD:409353	0/3 (0%)
		Ig strand E	607..614	CDD:409353	0/6 (0%)
		Ig strand F	620..629	CDD:409353	1/8 (13%)
		Ig strand G	633..646	CDD:409353	2/12 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41799at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820