Protein Alignment Sema5c and Sema5b

DIOPT Version :9

• Sequence 1: NP_611293.3
• Gene: Sema5c / 37066
• FlyBaseID: FBgn0284221
• Length: 1093
• Species: Drosophila melanogaster
• Sequence 2: XP_038944267.1
• Gene: Sema5b / 303901
• RGDID: 1308914
• Length: 1093
• Species: Rattus norvegicus
• Alignment Length: 1118
• Identity: 411/1118 - (36%)
• Similarity: 582/1118 - (52%)
• Gaps: 154/1118 - (13%)

  Fly    15 LWLLLILSLLTLEGPQPSTGSGYTTKSSVD---LLENDSRYISYQDLMSTAKRFYDPETTWYSEM 76
            |.|.|:|...||.....||....|::.|.:   ....:...::::||......|..|....:|::
  Rat     7 LALSLLLPSFTLLLSHLSTSQDITSEPSSEQQLCTRREHPIVAFEDLKPWVSNFTYPGVRDFSQL 71

  Fly    77 LFDVARNQVIVGARDTLYRMSF-DLEPLERASWGATPSEIAMCQAKGQSERWCRNYVRVLHSYGE 140
            ..|.:|||:|||||:.|:|:|. ::..|:...|.::......||:||::|..|:||||||...|
  Rat    72 ALDPSRNQLIVGARNYLFRLSLANVSLLQATEWASSEDTRRSCQSKGKTEEECQNYVRVLIVSG- 135

  Fly   141 NQLYACGTNAFQPSCSWRQMENLTVTGVD--SGVVKCPFHPQANSTSLLQSNGQLFVGTATDFSG 203
            .:::.||||||.|.||.||:.||: ..::  :||.:||:.|:.|||:::.|.|:|:..|..||||
  Rat   136 RKVFMCGTNAFSPVCSSRQVGNLS-RAIEKINGVARCPYDPRHNSTAVISSQGELYAATVIDFSG 199

  Fly   204 SDVAILRTGVESNKRFLRTKQYNNNWLSGAQFVGSFEAGHFVYFLLRESAAEHMSCGKVIYSRVA 268
            .|.||.|: :.|... |||.|||:.||:...||.:|:.|.|.||.|||:|.|| .||:.:|||||
  Rat   200 RDPAIYRS-LGSGPP-LRTAQYNSKWLNEPNFVAAFDIGLFAYFFLRENAVEH-DCGRTVYSRVA 261

  Fly   269 RVCKNDVGGGGQLLRDNWTSFLKARLNCSLPGEYPYYFDEIQGMTYAESESILYATFRTSGSSIF 333
            ||||||| ||..||.|.||:|:|||||||.|||.|:|::|:|...:...:.::|..|.|:.:||.
  Rat   262 RVCKNDV-GGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSAFHLPEQDLIYGVFTTNVNSIA 325

  Fly   334 GSAVCAYNLSSINAAFDGPFKQQEHSDAAWKTVNTNQRSQFQCGT------------SSIGHWLE 386
            .|||||:|||:|:.||:|||:.||:..|||..: .|....|||||            .|:   .:
  Rat   326 ASAVCAFNLSAISKAFNGPFRYQENPRAAWLPI-ANPIPNFQCGTLPETGPNENLTERSL---QD 386

  Fly   387 SSRYQLMDEAVQPIGAEPLYHSKLEQFGRLALDIINTKTEQVHVLFVAS-SGNHIKKLSVKYDGD 450
            :.|..||.|||||:..||.......:|..|.:|::..|....|||::.: ||..:|.||..  ..
  Rat   387 AQRLFLMSEAVQPVTPEPCVTQDSVRFSHLVVDLVQAKDTLYHVLYIGTESGTILKALSTA--SR 449

  Fly   451 GVQTC-LVELWQADDTGTSSLLNMAYLKVSDSLYLGTDLALTRIPAQHCSRHVSQSSCLNSMDPY 514
            .::.| |.||..........|.::..|..:.:||:|....:.|:|.:.||.::||.:||.:.|||
  Rat   450 SLRGCYLEELHVLPPGRLEPLRSLRILHSARALYVGLSDRVLRVPLERCSAYLSQGACLGARDPY 514

  Fly   515 CGWNELVERCMPQPQDSSVLQHWHQAPQIT-CPVLNAPIDGGWSTWSPWAVCQQHEQPDS-NCQC 577
            |||:...:.|... :|||.:..|.|  .|| |||.|...|||:..||||..|:..:..:| :|.|
  Rat   515 CGWDGKRQLCSTL-EDSSNMSLWIQ--NITACPVRNVTRDGGFGPWSPWKPCEHLDGDNSGSCLC 576

  Fly   578 RQRSCNNPQPQHGGATCEGISTQVTNCTQHGGWTEWSAWSPCSQTCGIAVKIRRRTCGNPRPAFG 642
            |.|||::|:|:.||..|.|.:..:.||:::|.||.||:|:.||.:|||..::|:|:|.||.|..|
  Rat   577 RARSCDSPRPRCGGLECLGPAIHIANCSRNGAWTAWSSWAQCSTSCGIGFQVRQRSCSNPAPRHG 641

  Fly   643 GRTCVGSEQSEMYCRHLPPCPVAKPQSVDGGWGPWGEWSECSAQCGGGFRMRRRECNDPAPLNGG 707
            ||.|||..:.|.:|....||||..      .|..||.||:||:.||||.:.|||.|.:      |
  Rat   642 GRICVGKSREERFCNENTPCPVPI------FWASWGSWSKCSSNCGGGVQSRRRSCEN------G 694

  Fly   708 MECPGCRLDYEECNMQSCQEVRKLSAWTPWL--TVTGSGNSSEPHMERRFRFVCRATSPDPSSVR 770
            ..||||.::::.||.::|.|||:.:.|||||  .||..|    ...|:||||.|||..|||..::
  Rat   695 NSCPGCGVEFKTCNPEACPEVRRNTPWTPWLPVNVTQGG----ARQEQRFRFTCRAPLPDPHGLQ 755

  Fly   771 IGLPKEESRNCHADGSCQRQVDHDSADSDA-----------------------ADWSPCSVSCGG 812
            .|..:.|:|.|.|||:       .:.|:||                       ..||.||..|..
  Rat   756 FGKRRTETRTCPADGT-------GACDTDALVEDLLRSGSTSPHTLSGGWATWGLWSSCSRDCEL 813

  Fly   813 GVQQRHR---------------GRGSQSRVCNIHACPAEEQLSSNSLDNELEHGEWGCWSEWSAC 862
            |.:.|.|               |..::.:.||..|||.              .|.|.||:.||.|
  Rat   814 GFRVRKRTCTNPEPRNGGLPCVGDAAEYQDCNPQACPV--------------RGAWSCWTAWSQC 864

  Fly   863 SVTCGLGLRRRTRRCLA-----GHDRLCQGRALEEQKCEMVPCEDFLGWSAWSEWSSCSSDGIRL 922
            |.:||.|..:|||.|.:     |.| :|.|...||..|....|.:  |||.||||..|:.||.:.
  Rat   865 SASCGGGHYQRTRSCTSPAPSPGED-ICLGLHTEEALCATQACPE--GWSLWSEWGVCTEDGAQS 926

  Fly   923 RHRRCLVEQPGSMECRGAEFEKTAC----VP-----NECEETQTASTATLPIVIFVGLLFTVACC 978
            |.|.|....||...|.|...:...|    :|     :..|||.:....:|..:|..|    |:|.
  Rat   927 RSRSCEELVPGPGACVGNSSQSRPCPYSEIPVILPASSVEETASCGGFSLIHLIVTG----VSCF 987

  Fly   979 LATYRFTKKRFMLSAEEALNKTTTTTASFDTYPN--QYSSLPTKDYYDQRPKRQSSFRMPAKTSN 1041
            |.:...|...: ||.:....::..:|......||  .|.|..|       ||.:....|..|
  Rat   988 LGSGLLTLAVY-LSCQHCQRQSQESTLVHPATPNHLHYKSGGT-------PKNEKYTPMEFK--- 1041

  Fly  1042 LGNGNGTLNRNNM 1054
                  |||:||:
  Rat  1042 ------TLNKNNL 1048

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	185/447 (41%)
		PSI	497..546	CDD:279745	20/49 (41%)
		TSP1	556..607	CDD:214559	20/51 (39%)
		TSP1	610..663	CDD:214559	25/52 (48%)
		TSP1	674..725	CDD:214559	22/50 (44%)
		TSP1	802..834	CDD:214559	12/46 (26%)
		TSP1	853..901	CDD:214559	21/52 (40%)
		TSP1	906..953	CDD:214559	18/55 (33%)
Sema5b	XP_038944267.1	Sema	60..496	CDD:417757	185/447 (41%)
		PSI	497..544	CDD:396154	20/49 (41%)
		TSP1	609..662	CDD:214559	25/52 (48%)
		TSP1	667..713	CDD:214559	22/51 (43%)
		TSP1	798..850	CDD:214559	12/51 (24%)
		TSP1	855..907	CDD:214559	21/52 (40%)
		TSP_1	911..952	CDD:417691	15/40 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	305	1.000	Domainoid score	I1320
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8427
Inparanoid	1	1.050	678	1.000	Inparanoid score	I690
OMA	1	1.010	-	-		QHG47498
OrthoDB	1	1.010	-	-		D41799at33208
OrthoFinder	1	1.000	-	-		FOG0003495
OrthoInspector	1	1.000	-	-		otm44984
orthoMCL	1	0.900	-	-		OOG6_106097
Panther	1	1.100	-	-	LDO	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2388
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.880