Protein Alignment Sema5c and Sema4c

DIOPT Version :10

• Sequence 1: NP_611293.3
• Gene: Sema5c / 37066
• FlyBaseID: FBgn0284221
• Length: 1093
• Species: Drosophila melanogaster
• Sequence 2: XP_006244820.1
• Gene: Sema4c / 301346
• RGDID: 1562837
• Length: 856
• Species: Rattus norvegicus
• Alignment Length: 782
• Identity: 209/782 - (26%)
• Similarity: 312/782 - (39%)
• Gaps: 168/782 - (21%)

  Fly    53 ISYQDLMSTAKRFYDPETTWYSEMLFDVARNQVIVGARDTLYRMSFDLEPLER---ASWGATPSE 114
            :|..:|::..:||.......:..:........:.||||:.|:  :|.:|.||.   .||.|...:
  Rat    55 VSSGELVTVVRRFSQTGIQDFLTLTLTDRSGLLYVGAREALF--AFSVEALELQGVISWEAPAEK 117

  Fly   115 IAMCQAKGQSERW-CRNYVRVLHSYGENQLYACGTNAFQPSCSWRQMENLTV--TGVDSGVVKCP 176
            ...|..||:|.:. |.|::|.|..|..:.||.|||.||||.|::..|...|:  ...:.|..|||
  Rat   118 KIECTQKGKSNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYINMLTFTLDRAEFEDGKGKCP 182

  Fly   177 FHPQANSTSLLQSNGQLFVGTATDFSGSDVAILRTGVESNKRFLRTKQYNNNWLSGAQFVGSF-- 239
            :.|....|.|| .:|:|:..|..:|.|::..|||.....:.  ::| :|...||:...||||.
  Rat   183 YDPAKGHTGLL-VDGELYSATLNNFLGTEPVILRNMGPHHP--IKT-EYLAFWLNEPHFVGSAFV 243

  Fly   240 --EAGHF------VYFLLRESAAEHMSCGKVIYSRVARVCKNDVGGGGQLLRDNWTSFLKARLNC 296
              ..|.|      :||...|.|.|:....:.:.:|||||||.|: ||.:.|:..||:||||||.|
  Rat   244 PESVGSFTGDDDKIYFFFSERAVEYDCYSEQVVARVARVCKGDM-GGARTLQKKWTTFLKARLVC 307

  Fly   297 SLPGEYPYYFDEIQ------GMTYAESESILYATFRTSGSSIFGSAVCAYNLSSINAAFDGPFKQ 355
            |.| ::..||::::      |.::  ..:..:|.|:.....:..||||.|.|..|...|:||||
  Rat   308 SAP-DWKVYFNQLRAVHTLLGASW--HNTTFFAVFQARWGDMDLSAVCEYQLEHIQQVFEGPFK- 368

  Fly   356 QEHSDAAWKTVNTNQRSQFQCGTSSIGHWLESSRY-----------------QLMDEAVQPIGAE 403
             |:|:.|.|..............|.|.:|...:.|                 .||:|.|:|....
  Rat   369 -EYSEQAQKWARYTDPVPTPRPGSCINNWHRDNGYTSSLELPDNTLNFIKKHPLMEEQVKPRLGR 432

  Fly   404 PLYHSKLEQFGRLALD-IINTKTEQVHVLFVAS-SGNHIKKLSVKYDGDGVQTCLVELWQA-DDT 465
            ||...|...|..:..| |:........|||:.: .|..:|.:|:     |....:||..|. |..
  Rat   433 PLLVKKNTNFTHVVADRILGLDGATYTVLFIGTGDGWLLKAVSL-----GPWIHMVEELQVFDQE 492

  Fly   466 GTSSLLNMAYLKVSDSLYLGTDLALTRIPAQHCSRHVSQSSCLNSMDPYCGWNELVERCMPQPQD 530
            ...||:.....||   |:.|:...|.::....|:::.....|:.:.||||.||....||:.....
  Rat   493 PVESLVLSQSKKV---LFAGSRSQLVQLSLADCTKYRFCVDCVLARDPYCAWNVNTSRCVATGGH 554

  Fly   531 SSVLQHWHQA---PQITC---------PVL--NAPIDGGWSTWSP-----------WAVCQQH-- 568
            |..|...|.|   |...|         ||:  |..:..|.....|           |....:.
  Rat   555 SGSLLVQHVANLDPSKMCIQYAIKKARPVVPKNITVVAGTDLVLPCHLSSNLAHALWTFRGRDLP 619

  Fly   569 -EQP-----DSNCQCRQRSCNNPQPQHGGATCEGISTQVTNCTQHGGWTEWSAWS-PCSQTCGIA 626
             |||     |:..|......  .|.:|.|.         .:|......|:.:|.| ..|...|.:
  Rat   620 AEQPGSFLYDTGLQALVVMA--AQSRHSGP---------YHCYSEEQGTKLAAESYLVSVVAGSS 673

  Fly   627 VKIRRRTCGNPRPAFG---------GRTCV-------------------GSEQSE---MYCRHLP 660
            |.:..|.   |....|         |..|:                   ||:.:|   :|...||
  Rat   674 VTLEARA---PLENLGLVWLAVVALGAVCLVLLLLVLSLRRRLREELEKGSKAAERTLVYPLELP 735

  Fly   661 PCPVAK-----PQSVDGGWGPWG-EWSECS-------AQC--GGGFRMRRRECNDPAPLNGGMEC 710
            ..|.:.     |::.:..|.|.| .:|:.|       |:|  |||         .|:|..|   .
  Rat   736 KEPASPPFRPGPETDEKLWDPVGYYYSDGSLKIVPGHARCQPGGG---------PPSPPPG---I 788

  Fly   711 PG 712
            ||
  Rat   789 PG 790

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	141/472 (30%)
		PSI	497..546	CDD:396154	16/60 (27%)
		TSP1	556..607	CDD:214559	11/69 (16%)
		TSP1	610..663	CDD:214559	17/84 (20%)
		TSP1	674..725	CDD:214559	15/49 (31%)
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
Sema4c	XP_006244820.1	Sema_4C	64..520	CDD:200519	142/475 (30%)
		PSI	521..>550	CDD:214655	10/28 (36%)
		Ig	586..670	CDD:472250	17/94 (18%)
		Ig strand B	596..600	CDD:409456	0/3 (0%)
		Ig strand C	608..612	CDD:409456	0/3 (0%)
		Ig strand E	633..637	CDD:409456	1/3 (33%)
		Ig strand F	647..652	CDD:409456	1/13 (8%)
		Ig strand G	664..667	CDD:409456	0/2 (0%)