DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema5c and Sema6c

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	NP_059004.1	Gene:	Sema6c / 29744	RGDID:	3659	Length:	960	Species:	Rattus norvegicus

Alignment Length:	912	Identity:	244/912 - (26%)
Similarity:	359/912 - (39%)	Gaps:	249/912 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LWLLLILSLLTLEGPQPSTGSGYTTKSSVDLLENDSRYISYQDLMSTAKRFYDPETTWY------ 73
            |.|||:|||     ||..|.   ..:..:.||.:        ||..|:      .::|:
  Rat    10 LLLLLLLSL-----PQAQTA---FPQDPIPLLTS--------DLQGTS------PSSWFRGLEDD 52

  Fly    74 ---SEMLFDVAR-----NQVIVGARDTLYRMSFDLEPLERASWGATPS--------EIAMCQAKG 122
               :|:..|..|     ..::|.|||.::  ||||:..|... |..|:        ::..|..:|
  Rat    53 AVAAELGLDFQRFLTLNRTLLVAARDHVF--SFDLQAQEEGE-GLVPNKFLTWRSQDMENCAVRG 114

  Fly   123 QSERWCRNYVRVLHSYGENQLYACGTNAFQPSCSWRQMENLTVTGVD-SGVVKCPFHPQANSTSL 186
            :....|.||:|||..:....|.|||||:|.|.|....:.:|...|.: ||..:||| ....||..
  Rat   115 KLTDECYNYIRVLVPWDSQTLLACGTNSFSPVCRSYGITSLQQEGEELSGQARCPF-DATQSTVA 178

  Fly   187 LQSNGQLFVGTATDFSGSDVAILRT-GVESNKRFLRTKQYNNNWLSGAQFVGSFEAGHFVYFLLR 250
            :.:.|.|:..||.||..||..:.|: |.:..   ||:.:|::.||....||.:.|.|..|||..|
  Rat   179 ISAEGSLYSATAADFQASDAVVYRSLGPQPP---LRSAKYDSKWLREPHFVYALEHGDHVYFFFR 240

  Fly   251 ESAAEHMSCGKVIYSRVARVCKNDVGGGGQLLRDNWTSFLKARLNCSLPGEYPYYFDEIQGMT-- 313
            |.:.|....|:|.:||||||||.|:||..:.|..:||||||.|||||:||:..:|||.:|.:|
  Rat   241 EVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQSLTGP 305

  Fly   314 -YAESESILYATFRTSGSSIFGSAVCAYNLSSINAAFDGPFKQQEHSDAAWKTVNTNQRSQFQCG 377
             .....|.|:..|.|..:||.||||||:.|..|...|:|.||:|...|.||..|:.::....:.|
  Rat   306 VNLHGRSALFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVSEDKVPSPRPG 370

  Fly   378 T-SSIG--HWLESSR------------YQLMDEAVQPIGAEPLY----HSKLEQFGRLALDIINT 423
            : :.:|  ....||:            :.|:|.||.|...:||.    .:.|.|   :|:|.:..
  Rat   371 SCAGVGAAALFSSSQDLPDDVLLFIKAHPLLDPAVPPATHQPLLTLTSRALLTQ---VAVDGMAG 432

  Fly   424 KTEQVHVLFVASS-GNHIKKLSVKYDGDGVQTCLVELWQADDTGTSS----------LLNMAYLK 477
            ......|||:.|: |..:|.|.......|.:..::|...|......|          ::.:....
  Rat   433 PHRNTTVLFLGSNDGTVLKVLPPGGQSLGPEPIILEEIDAYSHARCSGKRSPRAARRIIGLELDT 497

  Fly   478 VSDSLYLGTDLALTRIPAQHCSRH-VSQSSCLNSMDPYCGWNELVERCM----PQPQDSSV---- 533
            ....|::.....:..:....|:|| ..|.|||.|:||||||:.. ..|:    |...|..:
  Rat   498 EGHRLFVAFPGCIVYLSLSRCARHGACQRSCLASLDPYCGWHRF-RGCVNIRGPGGTDVDLTGNQ 561

  Fly   534 --LQHW---------HQAPQITCPVLNAPIDGGWSTWSPWAVCQQHEQPDSNCQCRQRSCNNPQP 587
              ::|.         ...|..:..||..|   |.|..:|.:....|..|.|:..
  Rat   562 ESMEHGDCQDGATGSQSGPGDSAYVLLGP---GPSPETPSSPSDAHPGPQSSTL----------- 612

  Fly   588 QHGGATCEGISTQVTNCTQHGGWTEWSAWSPCSQTCGIAVKI----------------------- 629
               ||..:|:...:               ||.|.:..|.:.:
  Rat   613 ---GAHTQGVRRDL---------------SPASASRSIPIPLLLACVAAAFALGASVSGLLVSCA 659

  Fly   630 -----RRR-----TCGNPRP--------AFGG--------RTCVGSEQSEMYCRHLPP------- 661
                 |||     |.|.|||        ..||        :....::..::|...|||
  Rat   660 CRRANRRRSKDIETPGLPRPLSLRSLARLHGGGPEPPPPPKDGDAAQTPQLYTTFLPPPEGGSPP 724

  Fly   662 ---C---PVAKPQ----SVDGGWGPWGEWSE--------------CSAQCGGGFRMRRRECNDPA 702
               |   |...|:    .:....||| ||::              |||..|...|:..|   .|.
  Rat   725 ELACLPTPETTPELPVKHLRASGGPW-EWNQNGNNASEGPGRPRGCSAAGGPAPRVLVR---PPP 785

  Fly   703 PLNGGMECPGCRLDYEECNMQSCQE-VRKLSAWTPWLTVTGSGNSSEPHMERRFRFVCRATSPDP 766
            |     .|||     :|..:.:.:| :|.|....|      ....|||.....|      ||..|
  Rat   786 P-----GCPG-----QEVEVTTLEELLRYLHGPQP------PRKGSEPLASAPF------TSRPP 828

  Fly   767 SS 768
            :|
  Rat   829 AS 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	148/487 (30%)
		PSI	497..546	CDD:279745	19/68 (28%)
		TSP1	556..607	CDD:214559	8/50 (16%)
		TSP1	610..663	CDD:214559	19/114 (17%)
		TSP1	674..725	CDD:214559	17/64 (27%)
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
Sema6c	NP_059004.1	Sema	52..516	CDD:417757	147/473 (31%)
		PSI	517..>538	CDD:396154	12/20 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	555..624		14/100 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..725		6/39 (15%)
		PHA03307	730..>956	CDD:223039	31/127 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	745..792		16/60 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	806..960		9/37 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810