DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema5c and Sema3e

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	NP_001100049.1	Gene:	Sema3e / 296789	RGDID:	1310973	Length:	775	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	159/573 - (27%)
Similarity:	258/573 - (45%)	Gaps:	109/573 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LWLLLILSLLTLEGPQPSTGSGYTTKSSVDLLENDSRYISYQDLMSTAKR--------FYDPETT 71
            |.|||...||.|..|      |||...|...|.     :|:::|:...:.        |.|..|
  Rat     8 LTLLLWGHLLELWTP------GYTANPSYPRLR-----LSHKELLELNRTSIFQSPFGFLDLHT- 60

  Fly    72 WYSEMLFDVARNQVIVGARDTLYRMSFDLEPLERAS-------WGATPSEIAMCQAKGQSERWCR 129
                ||.|..:.::.||.||.:|.::     |||.|       |.:|..::..|..||:....|.
  Rat    61 ----MLLDEYQERLFVGGRDLVYSLN-----LERVSDGYREIYWPSTAVKVEECIMKGKDANECA 116

  Fly   130 NYVRVLHSYGENQLYACGTNAFQPSCSWRQ--------MENLTVTGVDSGVVKCPFHPQANSTSL 186
            |||||||.|....|..|.|.||.|.|::.:        :.:|.....:.|..:|||.|.::..|.
  Rat   117 NYVRVLHHYNRTHLLTCATGAFDPHCAFIRVGHHSEDPLFHLESHRSERGRGRCPFDPNSSFVST 181

  Fly   187 LQSNGQLFVGTATDFSGSDVAILRTGVESNKRFLRTKQYNNNWLSGAQFVGSF-------EAGHF 244
            |..| :||.|..:|:.|.|.||.|:  ......:||:..:...|...:||||:       ...:.
  Rat   182 LVGN-ELFAGLYSDYWGRDSAIFRS--LGKLGHIRTEHDDERLLKEPKFVGSYMIPDNEDPEDNK 243

  Fly   245 VYFLLRESAAEHMSCGKVIYSRVARVCKNDVGGGGQLLRDNWTSFLKARLNCSLPG--EYPYYFD 307
            :||...|.|.|..:....||:||.|:|.||: ||.::|.:.|::||||||.||:||  ....:||
  Rat   244 MYFFFTEKALEAENNAHTIYTRVGRLCVNDM-GGQRILVNKWSTFLKARLVCSVPGMNGIDTHFD 307

  Fly   308 EIQGM----TYAESESILYATFRTSGSSIFGSAVCAYNLSSINAAFDGPFKQQEHSDAAWKTVNT 368
            |::.:    |......:::..|.|:.:...|.|||.|::|||..||:||:..:|..:..|
  Rat   308 ELEDVFLLPTRDPKNPVIFGLFNTTSNIFRGHAVCVYHMSSIREAFNGPYAHKEGPEYHW----- 367

  Fly   369 NQRSQFQ----------CGTSSIGHWLESSR------------YQLMDEAVQPIGAEPL------ 405
               |.::          |.:...|....|::            :.||.:.::|:..:|:
  Rat   368 ---SLYEGKVPYPRPGSCASKVNGGKYGSTKDYPDDAIRFARMHPLMYQPIKPVHKKPILVKTDG 429

  Fly   406 -YHSKLEQFGRLALDIINTKTEQVHVLFVASSGNHIKKLSVKYDGDG---VQTCLVELWQADDTG 466
             |:.:     :||:|.:..:..|..|||:.:....:.|:...|:.:.   .:..|.||....|
  Rat   430 KYNLR-----QLAVDRVEAEDGQYDVLFIGTDTGIVLKVITIYNQETEWMEEVILEELQIFKD-- 487

  Fly   467 TSSLLNMAYLKVSDSLYLGTDLALTRIPAQHCSRHVSQ-SSCLNSMDPYCGWN 518
            .:.:::|........||:|:..|:.::...||..:.|. :.|..:.||||.|:
  Rat   488 PAPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAWD 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	135/490 (28%)
		PSI	497..546	CDD:279745	9/23 (39%)
		TSP1	556..607	CDD:214559
		TSP1	610..663	CDD:214559
		TSP1	674..725	CDD:214559
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
Sema3e	NP_001100049.1	Sema_3E	49..519	CDD:200514	135/498 (27%)
		PSI	518..566	CDD:214655	9/23 (39%)
		Ig_Semaphorin_classIII	585..675	CDD:143279
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810