DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema5c and Sema2b

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster

Alignment Length:	796	Identity:	217/796 - (27%)
Similarity:	338/796 - (42%)	Gaps:	188/796 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GPQPSTGSGYTTKSSVD----LLENDSRYISY--QDLMSTAKRFYDPE----------------- 69
            |...:||.|.....|:.    :|...:.::.|  .|..:|...:|:|.
  Fly    47 GSMCATGKGKHRLCSLSALLLVLVAQTVHVEYARADYENTWNLYYEPPCCTGSSAAHHLRHHKEH 111

  Fly    70 -------TTWYSEMLFDVARNQVIVGARDTLYRMSFD-------------LEPLERASWGATPSE 114
                   ...|.....|...|.:.|||.|.::|::..             |||        |.|:
  Fly   112 VQDFSCGPLHYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEP--------TGSD 168

  Fly   115 IAMCQAKGQSER-WCRNYVRVLH--SYGENQLYACGTNAFQPSCSWRQMENLT-------VTGVD 169
            |..|.:||:.|: .|||::||:.  ::...:||.|||||..|. .:....|||       |.|:.
  Fly   169 ILNCVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAHNPK-DYVINANLTHLPRSQYVPGIG 232

  Fly   170 SGVVKCPFHPQANSTSLLQSNGQ------LFVGTATDFSGSDVAILRTGV--------ESNKRFL 220
            .|:.|||:.|..|||::...||.      |:.||..:|:.:|..|.|:.:        |:|  |.
  Fly   233 LGIGKCPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEAN--FK 295

  Fly   221 RTKQYNNNWLSGAQFVGSFEAGHFVYFLLRESAAEHMSCGKVIYSRVARVCKNDVGGGGQLLRDN 285
            ||.:|::..|....||||||.|.||||..||.|.|:::|||.:||||||||||| .||..::..|
  Fly   296 RTVKYDSKLLDKPNFVGSFEIGEFVYFFFREHAVEYINCGKAVYSRVARVCKND-RGGKYMISQN 359

  Fly   286 WTSFLKARLNCSLPGEYPYYFDEIQGM-TYAESESILYATFRTSGSSIFGSAVCAYNLSSINAAF 349
            |.::||||:|||:..|:|:||:|||.: .....::..||||.|:.:.:.|||||:|::..|||||
  Fly   360 WATYLKARMNCSISSEFPFYFNEIQSVYKMPTDDTKFYATFTTNTNGLIGSAVCSYDIRDINAAF 424

  Fly   350 DGPFKQQEHSDAAWKTVNTNQRSQFQCGT---------SSIGHWLESSRYQLMDEAVQPIGAEPL 405
            ||.||:|..|::||..|..::..:.:.||         .|:.:::.  ::.|||:||......|:
  Fly   425 DGKFKEQATSNSAWLPVLNSKVPEPRPGTCHNDTATLPDSVLNFIR--KHPLMDKAVDHEFGNPV 487

  Fly   406 YHSKLEQFGRLALDIINTK-----------TEQVHVLFVASSGNHIKKLSVKYDGDGVQ-TCLVE 458
            :..:         |:|.||           .::..|.|||::..||.|: |::...|.: :.||:
  Fly   488 FFKR---------DVILTKLVVDKIRIDKLNQEFLVYFVATTSGHIYKI-VQFMHYGQRHSNLVD 542

  Fly   459 LWQADDTGTSSLLNMAYLKVSDSLYLGTDLALTRIPAQHCSRHVSQSSCLNSM-DPYCGWNELVE 522
            :::| ...:..:..|.....:.|||:.||..:.:|....|:|.  ..||...: ||||||::.|.
  Fly   543 IFEA-SPHSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARR--YDSCFRCVSDPYCGWDKDVN 604

  Fly   523 RCMPQPQ--------------DSSVLQ-----HWHQAPQITCPV-LNAPIDGGWSTWSPWAVCQQ 567
            .|.|...              |:|||:     .:.|...::|.| :...:....:.|      ..
  Fly   605 ACRPYQLGLLQDVANETSGICDTSVLRKKVTSSYGQTLHLSCFVKMPEVLRKKQTRW------YH 663

  Fly   568 HEQPDSNCQCRQRSCNNPQPQHGGATCEGISTQVTNCTQHGGWTEWSAWSPCSQTCGIAVKIRRR 632
            |.......:.|...........||.        |......|....:.::...:..|...|.:...
  Fly   664 HSTEKGRYEVRYTPTKYIDTNEGGL--------VLLAVNEGDGGRYDSYLDGTLLCSYGVTVDAH 720

  Fly   633 TCGNPRPAFGGRTCVGSEQSEMYCRHLPPCPVAKPQSVDGGW--------GPWGEWSECSAQCG- 688
            .|..|            .|.:.|            |.:...|        ....:|.....|||
  Fly   721 RCSPP------------SQKQDY------------QKIYSHWCNEFEKYKSAMKQWQAKQEQCGL 761

  Fly   689 ----GGFRMRRRECND 700
                |......:..||
  Fly   762 KDKTGPISSNGKHVND 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	166/513 (32%)
		PSI	497..546	CDD:279745	18/68 (26%)
		TSP1	556..607	CDD:214559	6/50 (12%)
		TSP1	610..663	CDD:214559	6/52 (12%)
		TSP1	674..725	CDD:214559	8/40 (20%)
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	164/483 (34%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	12/101 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910