DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema5c and Sema7a

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	NP_035482.1	Gene:	Sema7a / 20361	MGIID:	1306826	Length:	664	Species:	Mus musculus

Alignment Length:	667	Identity:	153/667 - (22%)
Similarity:	247/667 - (37%)	Gaps:	120/667 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ILKLPKMFS---QLWLLLI--LSLLTLEGPQ---PSTGSGYTTKSSVDLLENDSRYISYQDLMST 61
            :|.||..|.   :|.|||:  ::..:.:|..   |...:.:..:..||
Mouse    18 VLSLPARFGLPLRLRLLLVFWVAAASAQGHSRSGPRISAVWKGQDHVD----------------- 65

  Fly    62 AKRFYDPETTWYSEMLFDVARNQVIVGARDTLYRMSFDLEPLERASWGATPSEIAMCQAKGQSER 126
               |..||.  ::.:..:.....|.||.|..:|..:|.    |..:.......|...:...|.::
Mouse    66 ---FSQPEP--HTVLFHEPGSFSVWVGGRGKVYHFNFP----EGKNASVRTVNIGSTKGSCQDKQ 121

  Fly   127 WCRNYVRVLHSYGENQLYACGTNAFQPSCSWRQMENLTVTGVDSGVVKCPFHPQANSTSLLQSNG 191
            .|.||:.:|...| |.|..|||||.:||| |..:.:..|..:.......||.|..||..|.:.:.
Mouse   122 DCGNYITLLERRG-NGLLVCGTNARKPSC-WNLVNDSVVMSLGEMKGYAPFSPDENSLVLFEGDE 184

  Fly   192 QLFVGTATDFSGSDVAILRTGVESNKRFLRTKQYNNNWLSGAQFVGSFEA-GHFVYFLLRESAAE 255
            ........:::|......|...||......|...|..::. |..|...:| ...:|:..||...:
Mouse   185 VYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIK-ATIVHQDQAYDDKIYYFFREDNPD 248

  Fly   256 HMSCGKVIYSRVARVCKNDVGGGGQLLRDNWTSFLKARLNCSLPGEYPYYFDEIQGMTYAESESI 320
            ......:..||||::|:.|.||...|....|.:||||.|.|| .......|:.:|.:......|.
Mouse   249 KNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCS-DAATNRNFNRLQDVFLLPDPSG 312

  Fly   321 LYATFRTSGSSIFG-----SAVCAYNLSSINAAFDGPFKQQEHSDAAWKTVNTNQRSQFQCGTSS 380
            .:...|..|  :|.     ||||.|:|..|:..|                 .|:....:..|..:
Mouse   313 QWRDTRVYG--VFSNPWNYSAVCVYSLGDIDRVF-----------------RTSSLKGYHMGLPN 358

  Fly   381 --IGHWLESSR------YQLMD------EAVQPIG--AEPLYHSKLEQFGRLALDIINTKTEQVH 429
              .|..|...:      :|:.|      :.|:|:|  ..||:|||......:...:..:..|..|
Mouse   359 PRPGMCLPKKQPIPTETFQVADSHPEVAQRVEPMGPLKTPLFHSKYHYQKVVVHRMQASNGETFH 423

  Fly   430 VLFVASSGNHIKKLSVKYDGDGVQTCLVELWQADDTGTSSLLNMAYLKVS-DSLYLGTDLALTRI 493
            ||::.:....|.|  |...||...:.:..:.:......::.:....|... ..||:.:...::::
Mouse   424 VLYLTTDRGTIHK--VVESGDQDHSFVFNIMEIQPFHRAAAIQAISLDADRRKLYVTSQWEVSQV 486

  Fly   494 PAQHCSRHVSQ-SSCLNSMDPYCGWNELVERCMP-QPQDSSVLQHWHQA-PQITCP--------- 546
            |...|..:... ..||.|.||||||::  :||:. .....||||..:.| |...||
Mouse   487 PLDMCEVYSGGCHGCLMSRDPYCGWDQ--DRCVSIYSSQRSVLQSINPAEPHRECPNPKPDEAPL 549

  Fly   547 -----------VLNAPIDGGWSTWSPWAVCQQHEQPDSNCQ--CRQRSC-----NNPQPQHGGAT 593
                       .|..|::...:|:. |   :..|..:.:|:  .:..||     |....|:|...
Mouse   550 QKVSLARNSRYYLTCPMESRHATYL-W---RHEENVEQSCEPGHQSPSCILFIENLTARQYGHYR 610

  Fly   594 CEGISTQVTNCTQHGGW 610
            ||..........||  |
Mouse   611 CEAQEGSYLREAQH--W 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	105/453 (23%)
		PSI	497..546	CDD:279745	18/51 (35%)
		TSP1	556..607	CDD:214559	11/57 (19%)
		TSP1	610..663	CDD:214559	1/1 (100%)
		TSP1	674..725	CDD:214559
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
Sema7a	NP_035482.1	Sema_7A	70..489	CDD:200504	103/449 (23%)
		Cell attachment site. /evidence=ECO:0000255	265..267		0/1 (0%)
		Interaction with integrins. /evidence=ECO:0000250	265..267		0/1 (0%)
		PSI	491..>518	CDD:279745	12/28 (43%)
		Ig	547..617	CDD:299845	13/73 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900