DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema5c and Sema6b

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	NP_001123928.1	Gene:	Sema6b / 20359	MGIID:	1202889	Length:	886	Species:	Mus musculus

Alignment Length:	476	Identity:	162/476 - (34%)
Similarity:	244/476 - (51%)	Gaps:	48/476 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 VIVGARDTLYRMSFDLEP--------LERASWGATPSEIAMCQAKGQSERWCRNYVRVLHSYGEN 141
            :.:|.||.||::  :|||        ..:.:|.:.||:|.:|:.||:.|..|||:|:||....|:
Mouse    78 LFIGDRDNLYQV--ELEPSTSTELRYQRKLTWRSNPSDIDVCRMKGKQEGECRNFVKVLLLRDES 140

  Fly   142 QLYACGTNAFQPSCSWRQMENLTVTGVD-SGVVKCPFHPQANSTSLLQSNGQLFVGTATDFSGSD 205
            .|:.||:|||.|.|:...|:.|.:.|.. ||:.:||:.|:..:.:|. |:|.||..|.|||...|
Mouse   141 TLFVCGSNAFNPICANYSMDTLQLLGDSISGMARCPYDPKHANVALF-SDGMLFTATVTDFLAID 204

  Fly   206 VAILRTGVESNKRFLRTKQYNNNWLSGAQFVGSFEAGHFVYFLLRESAAEHMSCGKVIYSRVARV 270
            ..|.|:  ..::..|||.::::.|.....||.:.|.|..|||..||.|.|.....||:.||||||
Mouse   205 AVIYRS--LGDRPTLRTVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARV 267

  Fly   271 CKNDVGGGGQLLRDNWTSFLKARLNCSLPGEYPYYFDEIQGMTYAES---ESILYATFRTSGSSI 332
            |||||||..::|...||||||||||||:||:..:||:.:|.:|...|   ..::.|.|.|..:||
Mouse   268 CKNDVGGSPRVLEKQWTSFLKARLNCSVPGDSHFYFNVLQAVTGVVSLGGRPVILAVFSTPSNSI 332

  Fly   333 FGSAVCAYNLSSINAAFDGPFKQQEHSDAAWKTVNTNQ--RSQFQCGTSSIGHWLESS------- 388
            .||||||::::.:.|.|:|.|::|:..::.|..|..:|  |.:..|..:....:..||
Mouse   333 PGSAVCAFDMNQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAPGMQYNASSALPDEIL 397

  Fly   389 ----RYQLMDEAVQPIGAEPLYHSKL--EQFGRLALDIINTKTEQVHVLFVASSGNHIKKLSVKY 447
                .:.||||||..:|..|.....|  .|..|:|:|:.........::|:.|....:.|..||.
Mouse   398 NFVKTHPLMDEAVPSLGHSPWIVRTLMRHQLTRVAVDVGAGPWGNQTIVFLGSEAGTVLKFLVKP 462

  Fly   448 D-------GDGVQTCLVELWQADDTGTSS--------LLNMAYLKVSDSLYLGTDLALTRIPAQH 497
            :       |..:.....|.::.|..|..|        ||::.....|..|.......:.|:|...
Mouse   463 NASVSGTTGPSIFLEEFETYRPDRCGRPSSAGEWGQRLLSLELDAASGGLLAAFPRCVVRVPVAR 527

  Fly   498 CSRHVS-QSSCLNSMDPYCGW 517
            |..:.. ..:|:.|.||||||
Mouse   528 CQLYSGCMKNCIGSQDPYCGW 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	153/452 (34%)
		PSI	497..546	CDD:279745	9/22 (41%)
		TSP1	556..607	CDD:214559
		TSP1	610..663	CDD:214559
		TSP1	674..725	CDD:214559
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
Sema6b	NP_001123928.1	Sema_6B	58..526	CDD:200528	153/452 (34%)
		PSI	527..573	CDD:214655	9/22 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..677
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..731
		PHA03269	708..>875	CDD:165527
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	761..886
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810